Unitary Properties of AMPA Receptors with Reduced Desensitization

Wild-type AMPA receptors display a characteristic rapidly desensitizing phenotype. Many studies point to the dimer interface between pairs of extracellular ligand binding domains as the key region controlling the rate at which the receptors desensitize. However, mutations at the extracellular end of...

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Veröffentlicht in:	Biophysical journal 2017-11, Vol.113 (10), p.2218-2235
Hauptverfasser:	Zhang, Wei, Eibl, Clarissa, Weeks, Autumn M., Riva, Irene, Li, Yan-jun, Plested, Andrew J.R., Howe, James R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzothiadiazines - pharmacology Cells Cells (biology) Demixing Desensitization Ion Channel Gating - drug effects Lipids Liquid phases Membranes Miscibility Mutagenesis Mutation Phase separation Phase transitions Probability Protein Multimerization Protein Structure, Quaternary Proteins Receptor mechanisms Receptors Receptors, AMPA - chemistry Receptors, AMPA - genetics Receptors, AMPA - metabolism Smooth boundaries Thermodynamics Transition temperature Transition temperatures Vacuoles Yeast α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
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