Is bone density associated with intervertebral disc pressure in healthy and degenerated discs?
The coupling of the intervertebral disc (IVD) and vertebra as a biomechanical unit suggests that changes in the distribution of pressure within the IVD (intradiscal pressure, IDP) as a result of disc degeneration can influence the distribution of bone density within the vertebra, and vice versa. The...
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description | The coupling of the intervertebral disc (IVD) and vertebra as a biomechanical unit suggests that changes in the distribution of pressure within the IVD (intradiscal pressure, IDP) as a result of disc degeneration can influence the distribution of bone density within the vertebra, and vice versa. The goal of this study was to assess the correspondence between IDP and bone density in the adjacent vertebrae, with emphasis on how this correspondence differs between healthy and degenerated IVDs. Bone density of the endplates and subchondral bone in regions adjacent to the anterior and posterior annulus fibrosus (aAF and pAF, respectively) and nucleus pulposus (NP) was measured via quantitative computed tomography (QCT) in 61 spine segments (T7-9, T9-11, T10-12; 71±14years). IDP was measured in the aAF, NP, and pAF regions in 26 of the spine segments (68±16years) while they were tested in flexed (5°) or erect postures. Disc degeneration was assessed by multiple grading schemes. No correlation was found between bone density and IDP in either posture (p>0.104). Regional variations in IDP and, to a greater extent bone density, were found to change with advancing degeneration: both IDP (p=0.045) and bone density (p=0.024) decreased in the NP region relative to the aAF region. The finding of only a modest correspondence between degeneration-associated changes in IDP and bone density may arise from complexity in how IDP relates to mechanical force transmission through the endplate and from limitations of the available IVD grading schemes in estimating the mechanical behavior of the IVD. |
doi_str_mv | 10.1016/j.jbiomech.2017.08.033 |
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The goal of this study was to assess the correspondence between IDP and bone density in the adjacent vertebrae, with emphasis on how this correspondence differs between healthy and degenerated IVDs. Bone density of the endplates and subchondral bone in regions adjacent to the anterior and posterior annulus fibrosus (aAF and pAF, respectively) and nucleus pulposus (NP) was measured via quantitative computed tomography (QCT) in 61 spine segments (T7-9, T9-11, T10-12; 71±14years). IDP was measured in the aAF, NP, and pAF regions in 26 of the spine segments (68±16years) while they were tested in flexed (5°) or erect postures. Disc degeneration was assessed by multiple grading schemes. No correlation was found between bone density and IDP in either posture (p>0.104). Regional variations in IDP and, to a greater extent bone density, were found to change with advancing degeneration: both IDP (p=0.045) and bone density (p=0.024) decreased in the NP region relative to the aAF region. The finding of only a modest correspondence between degeneration-associated changes in IDP and bone density may arise from complexity in how IDP relates to mechanical force transmission through the endplate and from limitations of the available IVD grading schemes in estimating the mechanical behavior of the IVD.</description><identifier>ISSN: 0021-9290</identifier><identifier>EISSN: 1873-2380</identifier><identifier>DOI: 10.1016/j.jbiomech.2017.08.033</identifier><identifier>PMID: 28943155</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Age ; Aged ; Aged, 80 and over ; Annulus fibrosus ; Arthritis ; Biomechanics ; Bone Density ; Computed tomography ; Degeneration ; Disc degeneration ; Disc space narrowing ; Endplate ; Evaluation ; Female ; Fractures ; Glycosaminoglycan ; Grading ; Humans ; Intervertebral disc ; Intervertebral Disc - physiology ; Intervertebral Disc Degeneration - physiopathology ; Intervertebral discs ; Male ; Mechanical properties ; Medical imaging ; Middle Aged ; Morphology ; NMR ; Nuclear magnetic resonance ; Nuclei ; Nucleus pulposus ; Osteoporosis ; Posture ; Pressure ; Segments ; Spine ; Stress concentration ; Subchondral bone ; Thoracic Vertebrae - physiology ; Tomography ; Vertebra ; Vertebrae</subject><ispartof>Journal of biomechanics, 2017-11, Vol.64, p.41-48</ispartof><rights>2017 Elsevier Ltd</rights><rights>Copyright © 2017 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Nov 7, 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-ef8c214e186fe64e328047b6c4719253a1d5b830ea1b8d30b3ac03fd0fee26763</citedby><cites>FETCH-LOGICAL-c499t-ef8c214e186fe64e328047b6c4719253a1d5b830ea1b8d30b3ac03fd0fee26763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1965445248?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,64361,64363,64365,65309,72215</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28943155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fein, Paul M.</creatorcontrib><creatorcontrib>DelMonaco, Alexander</creatorcontrib><creatorcontrib>Jackman, Timothy M.</creatorcontrib><creatorcontrib>Curtiss, Cameron</creatorcontrib><creatorcontrib>Guermazi, Ali</creatorcontrib><creatorcontrib>Barest, Glenn D.</creatorcontrib><creatorcontrib>Morgan, Elise F.</creatorcontrib><title>Is bone density associated with intervertebral disc pressure in healthy and degenerated discs?</title><title>Journal of biomechanics</title><addtitle>J Biomech</addtitle><description>The coupling of the intervertebral disc (IVD) and vertebra as a biomechanical unit suggests that changes in the distribution of pressure within the IVD (intradiscal pressure, IDP) as a result of disc degeneration can influence the distribution of bone density within the vertebra, and vice versa. The goal of this study was to assess the correspondence between IDP and bone density in the adjacent vertebrae, with emphasis on how this correspondence differs between healthy and degenerated IVDs. Bone density of the endplates and subchondral bone in regions adjacent to the anterior and posterior annulus fibrosus (aAF and pAF, respectively) and nucleus pulposus (NP) was measured via quantitative computed tomography (QCT) in 61 spine segments (T7-9, T9-11, T10-12; 71±14years). IDP was measured in the aAF, NP, and pAF regions in 26 of the spine segments (68±16years) while they were tested in flexed (5°) or erect postures. Disc degeneration was assessed by multiple grading schemes. No correlation was found between bone density and IDP in either posture (p>0.104). Regional variations in IDP and, to a greater extent bone density, were found to change with advancing degeneration: both IDP (p=0.045) and bone density (p=0.024) decreased in the NP region relative to the aAF region. The finding of only a modest correspondence between degeneration-associated changes in IDP and bone density may arise from complexity in how IDP relates to mechanical force transmission through the endplate and from limitations of the available IVD grading schemes in estimating the mechanical behavior of the IVD.</description><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Annulus fibrosus</subject><subject>Arthritis</subject><subject>Biomechanics</subject><subject>Bone Density</subject><subject>Computed tomography</subject><subject>Degeneration</subject><subject>Disc degeneration</subject><subject>Disc space narrowing</subject><subject>Endplate</subject><subject>Evaluation</subject><subject>Female</subject><subject>Fractures</subject><subject>Glycosaminoglycan</subject><subject>Grading</subject><subject>Humans</subject><subject>Intervertebral disc</subject><subject>Intervertebral Disc - physiology</subject><subject>Intervertebral Disc Degeneration - physiopathology</subject><subject>Intervertebral discs</subject><subject>Male</subject><subject>Mechanical properties</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Morphology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Nuclei</subject><subject>Nucleus pulposus</subject><subject>Osteoporosis</subject><subject>Posture</subject><subject>Pressure</subject><subject>Segments</subject><subject>Spine</subject><subject>Stress concentration</subject><subject>Subchondral bone</subject><subject>Thoracic Vertebrae - physiology</subject><subject>Tomography</subject><subject>Vertebra</subject><subject>Vertebrae</subject><issn>0021-9290</issn><issn>1873-2380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkUtv1DAUhS0EokPhL1SR2LBJ8CuOveGhikelSmxgi-XYN42jGXuwnUH993iYtgI2rLy43zm-5x6ELgjuCCbi9dIto487sHNHMRk6LDvM2CO0IXJgLWUSP0YbjClpFVX4DD3LecEYD3xQT9EZlYoz0vcb9P0qN2MM0DgI2ZfbxuQcrTcFXPPTl7nxoUA6QCowJrNtnM-22SfIeU1Qh80MZlvmqguuetxAgPRbfATz2-foyWS2GV7cvefo28cPXy8_t9dfPl1dvr9uLVeqtDBJSwkHIsUEggOjEvNhFJYPRNGeGeL6UTIMhozSMTwyYzGbHJ4AqBgEO0dvTr77ddyBsxBK3Vbvk9-ZdKuj8frvSfCzvokH3QuluCDV4NWdQYo_VshF72oA2G5NgLhmTRSnQ738ICv68h90iWsKNV6lRM95T_mREifKpphzgulhGYL1sUK96PsK9bFCjaWuFVbhxZ9RHmT3nVXg3QmAetCDh6Sz9RAsOJ_AFu2i_98fvwAgj7I4</recordid><startdate>20171107</startdate><enddate>20171107</enddate><creator>Fein, Paul M.</creator><creator>DelMonaco, Alexander</creator><creator>Jackman, Timothy M.</creator><creator>Curtiss, Cameron</creator><creator>Guermazi, Ali</creator><creator>Barest, Glenn D.</creator><creator>Morgan, Elise F.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TB</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20171107</creationdate><title>Is bone density associated with intervertebral disc pressure in healthy and degenerated discs?</title><author>Fein, Paul M. ; DelMonaco, Alexander ; Jackman, Timothy M. ; Curtiss, Cameron ; Guermazi, Ali ; Barest, Glenn D. ; Morgan, Elise F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-ef8c214e186fe64e328047b6c4719253a1d5b830ea1b8d30b3ac03fd0fee26763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Annulus fibrosus</topic><topic>Arthritis</topic><topic>Biomechanics</topic><topic>Bone Density</topic><topic>Computed tomography</topic><topic>Degeneration</topic><topic>Disc degeneration</topic><topic>Disc space narrowing</topic><topic>Endplate</topic><topic>Evaluation</topic><topic>Female</topic><topic>Fractures</topic><topic>Glycosaminoglycan</topic><topic>Grading</topic><topic>Humans</topic><topic>Intervertebral disc</topic><topic>Intervertebral Disc - physiology</topic><topic>Intervertebral Disc Degeneration - physiopathology</topic><topic>Intervertebral discs</topic><topic>Male</topic><topic>Mechanical properties</topic><topic>Medical imaging</topic><topic>Middle Aged</topic><topic>Morphology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Nuclei</topic><topic>Nucleus pulposus</topic><topic>Osteoporosis</topic><topic>Posture</topic><topic>Pressure</topic><topic>Segments</topic><topic>Spine</topic><topic>Stress concentration</topic><topic>Subchondral bone</topic><topic>Thoracic Vertebrae - physiology</topic><topic>Tomography</topic><topic>Vertebra</topic><topic>Vertebrae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fein, Paul M.</creatorcontrib><creatorcontrib>DelMonaco, Alexander</creatorcontrib><creatorcontrib>Jackman, Timothy M.</creatorcontrib><creatorcontrib>Curtiss, Cameron</creatorcontrib><creatorcontrib>Guermazi, Ali</creatorcontrib><creatorcontrib>Barest, Glenn D.</creatorcontrib><creatorcontrib>Morgan, Elise F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of biomechanics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fein, Paul M.</au><au>DelMonaco, Alexander</au><au>Jackman, Timothy M.</au><au>Curtiss, Cameron</au><au>Guermazi, Ali</au><au>Barest, Glenn D.</au><au>Morgan, Elise F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is bone density associated with intervertebral disc pressure in healthy and degenerated discs?</atitle><jtitle>Journal of biomechanics</jtitle><addtitle>J Biomech</addtitle><date>2017-11-07</date><risdate>2017</risdate><volume>64</volume><spage>41</spage><epage>48</epage><pages>41-48</pages><issn>0021-9290</issn><eissn>1873-2380</eissn><abstract>The coupling of the intervertebral disc (IVD) and vertebra as a biomechanical unit suggests that changes in the distribution of pressure within the IVD (intradiscal pressure, IDP) as a result of disc degeneration can influence the distribution of bone density within the vertebra, and vice versa. The goal of this study was to assess the correspondence between IDP and bone density in the adjacent vertebrae, with emphasis on how this correspondence differs between healthy and degenerated IVDs. Bone density of the endplates and subchondral bone in regions adjacent to the anterior and posterior annulus fibrosus (aAF and pAF, respectively) and nucleus pulposus (NP) was measured via quantitative computed tomography (QCT) in 61 spine segments (T7-9, T9-11, T10-12; 71±14years). IDP was measured in the aAF, NP, and pAF regions in 26 of the spine segments (68±16years) while they were tested in flexed (5°) or erect postures. Disc degeneration was assessed by multiple grading schemes. No correlation was found between bone density and IDP in either posture (p>0.104). Regional variations in IDP and, to a greater extent bone density, were found to change with advancing degeneration: both IDP (p=0.045) and bone density (p=0.024) decreased in the NP region relative to the aAF region. The finding of only a modest correspondence between degeneration-associated changes in IDP and bone density may arise from complexity in how IDP relates to mechanical force transmission through the endplate and from limitations of the available IVD grading schemes in estimating the mechanical behavior of the IVD.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>28943155</pmid><doi>10.1016/j.jbiomech.2017.08.033</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Age Aged Aged, 80 and over Annulus fibrosus Arthritis Biomechanics Bone Density Computed tomography Degeneration Disc degeneration Disc space narrowing Endplate Evaluation Female Fractures Glycosaminoglycan Grading Humans Intervertebral disc Intervertebral Disc - physiology Intervertebral Disc Degeneration - physiopathology Intervertebral discs Male Mechanical properties Medical imaging Middle Aged Morphology NMR Nuclear magnetic resonance Nuclei Nucleus pulposus Osteoporosis Posture Pressure Segments Spine Stress concentration Subchondral bone Thoracic Vertebrae - physiology Tomography Vertebra Vertebrae |
title | Is bone density associated with intervertebral disc pressure in healthy and degenerated discs? |
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