Aerosol furosemide for dyspnea: Controlled delivery does not improve effectiveness

•We tested hypotheses that might explain failure of aerosol furosemide to alleviate experimental dyspnea.•Control of aerosol delivery did not increase the proportion of subjects who responded.•Response variation was partially explained by variation of response to large breaths.•Response variation wa...

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Veröffentlicht in:	Respiratory physiology & neurobiology 2018-01, Vol.247, p.146-155
Hauptverfasser:	Morélot-Panzini, Capucine, O’Donnell, Carl R., Lansing, Robert W., Schwartzstein, Richard M., Banzett, Robert B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Aerosols Cross-Over Studies Double-Blind Method Dyspnea Dyspnea - drug therapy Dyspnea - physiopathology Female Furosemide Furosemide - administration & dosage Humans Hypercapnia - drug therapy Hypercapnia - physiopathology Life Sciences Male Pain - drug therapy Pain - physiopathology Pain Measurement Palliative Care Respiration - drug effects Sodium Potassium Chloride Symporter Inhibitors - administration & dosage Symptom management Tidal Volume Treatment Outcome
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