Thrombocytosis in 715 Dogs (2011–2015)
Background Thrombocytosis is a hematologic abnormality in dogs that has been associated with various neoplastic, metabolic, and inflammatory conditions. Objective To classify thrombocytosis in dogs based on severity and evaluate whether there are associations between severity and underlying disease...
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| Veröffentlicht in: | Journal of veterinary internal medicine 2017-11, Vol.31 (6), p.1691-1699 |
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| container_title | Journal of veterinary internal medicine |
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| creator | Woolcock, A.D Keenan, A. Cheung, C. Christian, J.A. Moore, G.E. |
| description | Background
Thrombocytosis is a hematologic abnormality in dogs that has been associated with various neoplastic, metabolic, and inflammatory conditions.
Objective
To classify thrombocytosis in dogs based on severity and evaluate whether there are associations between severity and underlying disease processes.
Animals
Seven hundred and fifteen dogs with thrombocytosis and 1,430 dogs with normal numbers of platelets.
Methods
Retrospective study. Medical records of dogs with increased (>500 × 103/μL; thrombocytosis group) and normal (300–500 × 103/μL; control group) platelet counts between 2011 and 2015 were reviewed. Dogs were characterized by severity of platelet increase and diagnosis. Diagnostic categories included neoplasia, endocrine disease, inflammatory disease, or miscellaneous.
Results
A total of 1,254 complete blood counts with thrombocytosis from 715 dogs were included in the study. Median platelet count in this population was 582 × 103/μL (500–1,810 × 103/μL). No correlation between severity of thrombocytosis and diagnosis was identified. Causes of secondary thrombocytosis included neoplasia (55.7%), endocrine disease (12.0%), and inflammatory disease (46.6%). Immune‐mediated disease was common (22.2%), associated with frequent glucocorticoid administration, and had a significantly higher median platelet count (636 × 103/μL [500–1,262 × 103/μL] versus 565 × 103/μL [500–1,810 × 103/μL]) when compared to the other inflammatory processes (P |
| doi_str_mv | 10.1111/jvim.14831 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5697177</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1938187065</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5191-9ca385a4f74ea951308359e045b7be9c55bb70153e480dd4ebda5ce2933ba3c33</originalsourceid><addsrcrecordid>eNqFkctOAjEUhhujEUQ3PoBhiSZgz3TOtN2YGLxhMG7QbdMpBYbMUJwChp3v4Bv6JBZBohvt5iz65TuXn5BjoC0I73y8yIoWxILBDqmCZLIJCU92SZUKCc0kiWmFHHg_pjRCRL5PKpEQEiMqqqTRG5WuSJ1ZzpzPfD2b1Dlg_coNfb0RUYCPt_dQ8PSQ7A107u3RptbI0811r33X7D7edtqX3aZBCN2k0Uygjgc8tloiMCoYSktjTHlqpUFMUx58zMaC9vuxTfsajY0kY6lmhrEauVh7p_O0sH1jJ7NS52paZoUul8rpTP3-mWQjNXQLhYnkwHkQNDaC0r3MrZ-pIvPG5rmeWDf3KmxDI4gj_B8NtxQgOE0woGdr1JTO-9IOthMBVasU1CoF9ZVCgE9-7rBFv88eAFgDr1lul3-o1P1z52Et_QTDnJAH</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1938187065</pqid></control><display><type>article</type><title>Thrombocytosis in 715 Dogs (2011–2015)</title><source>Wiley Online Library Open Access</source><source>DOAJ Directory of Open Access Journals</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Woolcock, A.D ; Keenan, A. ; Cheung, C. ; Christian, J.A. ; Moore, G.E.</creator><creatorcontrib>Woolcock, A.D ; Keenan, A. ; Cheung, C. ; Christian, J.A. ; Moore, G.E.</creatorcontrib><description>Background
Thrombocytosis is a hematologic abnormality in dogs that has been associated with various neoplastic, metabolic, and inflammatory conditions.
Objective
To classify thrombocytosis in dogs based on severity and evaluate whether there are associations between severity and underlying disease processes.
Animals
Seven hundred and fifteen dogs with thrombocytosis and 1,430 dogs with normal numbers of platelets.
Methods
Retrospective study. Medical records of dogs with increased (>500 × 103/μL; thrombocytosis group) and normal (300–500 × 103/μL; control group) platelet counts between 2011 and 2015 were reviewed. Dogs were characterized by severity of platelet increase and diagnosis. Diagnostic categories included neoplasia, endocrine disease, inflammatory disease, or miscellaneous.
Results
A total of 1,254 complete blood counts with thrombocytosis from 715 dogs were included in the study. Median platelet count in this population was 582 × 103/μL (500–1,810 × 103/μL). No correlation between severity of thrombocytosis and diagnosis was identified. Causes of secondary thrombocytosis included neoplasia (55.7%), endocrine disease (12.0%), and inflammatory disease (46.6%). Immune‐mediated disease was common (22.2%), associated with frequent glucocorticoid administration, and had a significantly higher median platelet count (636 × 103/μL [500–1,262 × 103/μL] versus 565 × 103/μL [500–1,810 × 103/μL]) when compared to the other inflammatory processes (P < 0.001). The diagnoses in the thrombocytosis dogs differed significantly from the control population (P < 0.001).
Conclusions and Clinical Importance
Thrombocytosis is commonly associated with carcinoma and immune‐mediated disease in dogs.</description><identifier>ISSN: 0891-6640</identifier><identifier>EISSN: 1939-1676</identifier><identifier>DOI: 10.1111/jvim.14831</identifier><identifier>PMID: 28895208</identifier><language>eng</language><publisher>United States: John Wiley and Sons Inc</publisher><subject>blood platelet count ; blood platelets ; carcinoma ; dogs ; Inflammation ; medical records ; Neoplasia ; Platelets ; Pseudohyperkalemia ; retrospective studies ; SMALL ANIMAL</subject><ispartof>Journal of veterinary internal medicine, 2017-11, Vol.31 (6), p.1691-1699</ispartof><rights>Copyright © 2017 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5191-9ca385a4f74ea951308359e045b7be9c55bb70153e480dd4ebda5ce2933ba3c33</citedby><cites>FETCH-LOGICAL-c5191-9ca385a4f74ea951308359e045b7be9c55bb70153e480dd4ebda5ce2933ba3c33</cites><orcidid>0000-0001-7102-3224</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697177/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697177/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28895208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Woolcock, A.D</creatorcontrib><creatorcontrib>Keenan, A.</creatorcontrib><creatorcontrib>Cheung, C.</creatorcontrib><creatorcontrib>Christian, J.A.</creatorcontrib><creatorcontrib>Moore, G.E.</creatorcontrib><title>Thrombocytosis in 715 Dogs (2011–2015)</title><title>Journal of veterinary internal medicine</title><addtitle>J Vet Intern Med</addtitle><description>Background
Thrombocytosis is a hematologic abnormality in dogs that has been associated with various neoplastic, metabolic, and inflammatory conditions.
Objective
To classify thrombocytosis in dogs based on severity and evaluate whether there are associations between severity and underlying disease processes.
Animals
Seven hundred and fifteen dogs with thrombocytosis and 1,430 dogs with normal numbers of platelets.
Methods
Retrospective study. Medical records of dogs with increased (>500 × 103/μL; thrombocytosis group) and normal (300–500 × 103/μL; control group) platelet counts between 2011 and 2015 were reviewed. Dogs were characterized by severity of platelet increase and diagnosis. Diagnostic categories included neoplasia, endocrine disease, inflammatory disease, or miscellaneous.
Results
A total of 1,254 complete blood counts with thrombocytosis from 715 dogs were included in the study. Median platelet count in this population was 582 × 103/μL (500–1,810 × 103/μL). No correlation between severity of thrombocytosis and diagnosis was identified. Causes of secondary thrombocytosis included neoplasia (55.7%), endocrine disease (12.0%), and inflammatory disease (46.6%). Immune‐mediated disease was common (22.2%), associated with frequent glucocorticoid administration, and had a significantly higher median platelet count (636 × 103/μL [500–1,262 × 103/μL] versus 565 × 103/μL [500–1,810 × 103/μL]) when compared to the other inflammatory processes (P < 0.001). The diagnoses in the thrombocytosis dogs differed significantly from the control population (P < 0.001).
Conclusions and Clinical Importance
Thrombocytosis is commonly associated with carcinoma and immune‐mediated disease in dogs.</description><subject>blood platelet count</subject><subject>blood platelets</subject><subject>carcinoma</subject><subject>dogs</subject><subject>Inflammation</subject><subject>medical records</subject><subject>Neoplasia</subject><subject>Platelets</subject><subject>Pseudohyperkalemia</subject><subject>retrospective studies</subject><subject>SMALL ANIMAL</subject><issn>0891-6640</issn><issn>1939-1676</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNqFkctOAjEUhhujEUQ3PoBhiSZgz3TOtN2YGLxhMG7QbdMpBYbMUJwChp3v4Bv6JBZBohvt5iz65TuXn5BjoC0I73y8yIoWxILBDqmCZLIJCU92SZUKCc0kiWmFHHg_pjRCRL5PKpEQEiMqqqTRG5WuSJ1ZzpzPfD2b1Dlg_coNfb0RUYCPt_dQ8PSQ7A107u3RptbI0811r33X7D7edtqX3aZBCN2k0Uygjgc8tloiMCoYSktjTHlqpUFMUx58zMaC9vuxTfsajY0kY6lmhrEauVh7p_O0sH1jJ7NS52paZoUul8rpTP3-mWQjNXQLhYnkwHkQNDaC0r3MrZ-pIvPG5rmeWDf3KmxDI4gj_B8NtxQgOE0woGdr1JTO-9IOthMBVasU1CoF9ZVCgE9-7rBFv88eAFgDr1lul3-o1P1z52Et_QTDnJAH</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Woolcock, A.D</creator><creator>Keenan, A.</creator><creator>Cheung, C.</creator><creator>Christian, J.A.</creator><creator>Moore, G.E.</creator><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7102-3224</orcidid></search><sort><creationdate>201711</creationdate><title>Thrombocytosis in 715 Dogs (2011–2015)</title><author>Woolcock, A.D ; Keenan, A. ; Cheung, C. ; Christian, J.A. ; Moore, G.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5191-9ca385a4f74ea951308359e045b7be9c55bb70153e480dd4ebda5ce2933ba3c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>blood platelet count</topic><topic>blood platelets</topic><topic>carcinoma</topic><topic>dogs</topic><topic>Inflammation</topic><topic>medical records</topic><topic>Neoplasia</topic><topic>Platelets</topic><topic>Pseudohyperkalemia</topic><topic>retrospective studies</topic><topic>SMALL ANIMAL</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Woolcock, A.D</creatorcontrib><creatorcontrib>Keenan, A.</creatorcontrib><creatorcontrib>Cheung, C.</creatorcontrib><creatorcontrib>Christian, J.A.</creatorcontrib><creatorcontrib>Moore, G.E.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of veterinary internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Woolcock, A.D</au><au>Keenan, A.</au><au>Cheung, C.</au><au>Christian, J.A.</au><au>Moore, G.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thrombocytosis in 715 Dogs (2011–2015)</atitle><jtitle>Journal of veterinary internal medicine</jtitle><addtitle>J Vet Intern Med</addtitle><date>2017-11</date><risdate>2017</risdate><volume>31</volume><issue>6</issue><spage>1691</spage><epage>1699</epage><pages>1691-1699</pages><issn>0891-6640</issn><eissn>1939-1676</eissn><abstract>Background
Thrombocytosis is a hematologic abnormality in dogs that has been associated with various neoplastic, metabolic, and inflammatory conditions.
Objective
To classify thrombocytosis in dogs based on severity and evaluate whether there are associations between severity and underlying disease processes.
Animals
Seven hundred and fifteen dogs with thrombocytosis and 1,430 dogs with normal numbers of platelets.
Methods
Retrospective study. Medical records of dogs with increased (>500 × 103/μL; thrombocytosis group) and normal (300–500 × 103/μL; control group) platelet counts between 2011 and 2015 were reviewed. Dogs were characterized by severity of platelet increase and diagnosis. Diagnostic categories included neoplasia, endocrine disease, inflammatory disease, or miscellaneous.
Results
A total of 1,254 complete blood counts with thrombocytosis from 715 dogs were included in the study. Median platelet count in this population was 582 × 103/μL (500–1,810 × 103/μL). No correlation between severity of thrombocytosis and diagnosis was identified. Causes of secondary thrombocytosis included neoplasia (55.7%), endocrine disease (12.0%), and inflammatory disease (46.6%). Immune‐mediated disease was common (22.2%), associated with frequent glucocorticoid administration, and had a significantly higher median platelet count (636 × 103/μL [500–1,262 × 103/μL] versus 565 × 103/μL [500–1,810 × 103/μL]) when compared to the other inflammatory processes (P < 0.001). The diagnoses in the thrombocytosis dogs differed significantly from the control population (P < 0.001).
Conclusions and Clinical Importance
Thrombocytosis is commonly associated with carcinoma and immune‐mediated disease in dogs.</abstract><cop>United States</cop><pub>John Wiley and Sons Inc</pub><pmid>28895208</pmid><doi>10.1111/jvim.14831</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-7102-3224</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of veterinary internal medicine, 2017-11, Vol.31 (6), p.1691-1699 |
| issn | 0891-6640 1939-1676 |
| language | eng |
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| source | Wiley Online Library Open Access; DOAJ Directory of Open Access Journals; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | blood platelet count blood platelets carcinoma dogs Inflammation medical records Neoplasia Platelets Pseudohyperkalemia retrospective studies SMALL ANIMAL |
| title | Thrombocytosis in 715 Dogs (2011–2015) |
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