Tubulointerstitial fibrosis can sensitize the kidney to subsequent glomerular injury

Chronic glomerular injury is associated with eventual development of tubulointerstitial fibrosis. Here we aimed to assess whether, and how, mild chronic tubulointerstitial injury affects glomeruli. For this, we generated mice expressing different toxin receptors, one on their proximal tubular epithe...

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Veröffentlicht in:	Kidney international 2017-12, Vol.92 (6), p.1395-1403
Hauptverfasser:	Lim, Beom Jin, Yang, Jae Won, Zou, Jun, Zhong, Jianyong, Matsusaka, Taiji, Pastan, Ira, Zhang, Ming-Zhi, Harris, Raymond C., Yang, Hai-Chun, Fogo, Agnes B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - toxicity atubular glomeruli Diphtheria Toxin - toxicity Disease Models, Animal Exotoxins - toxicity Fibrosis glomerular injury Heparin-binding EGF-like Growth Factor - genetics Humans Interleukin-2 Receptor alpha Subunit - genetics Kidney Diseases - chemically induced Kidney Diseases - pathology Kidney Diseases - urine Kidney Glomerulus - cytology Kidney Glomerulus - drug effects Kidney Glomerulus - pathology Kidney Tubules - blood supply Kidney Tubules - drug effects Kidney Tubules - pathology Male Membrane Proteins - genetics Mice Mice, Inbred C57BL Mice, Transgenic Podocytes - drug effects Podocytes - metabolism Promoter Regions, Genetic - genetics Proteinuria - chemically induced Proteinuria - pathology Proteinuria - urine Sclerosis tubuloglomerular feedback tubulointerstitial fibrosis
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