Testis Determination Requires a Specific FGFR2 Isoform to Repress FOXL2

Male sex determination in mammals relies on sex determining region Y–mediated upregulation of sex determining region–box 9 (SOX9) expression in XY gonads, whereas Wnt family member (WNT)/R-spondin 1 signaling and forkhead box L2 (FOXL2) drive female sex determination in XX gonads. Fibroblast growth...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2017-11, Vol.158 (11), p.3832-3843
Hauptverfasser:	Bagheri-Fam, Stefan, Bird, Anthony D, Zhao, Liang, Ryan, Janelle M, Yong, Meiyun, Wilhelm, Dagmar, Koopman, Peter, Eswarakumar, Veraragavan P, Harley, Vincent R
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Animals Down-Regulation - genetics Ectopic expression Editor's Choice Embryo, Mammalian Embryonic Development - genetics Embryos Endocrinology Female Females Fibroblast growth factor receptor 2 Fibroblast growth factor receptor 9 Fibroblast growth factors Fibroblasts Forkhead Box Protein L2 - genetics Forkhead protein FOXL2 gene Gene expression Gene Expression Regulation, Developmental Gonads Growth factors Ligands Male Males Mice Mice, Inbred C57BL Mice, Transgenic Mutation Ovaries Ovary - embryology Ovary - metabolism Protein Isoforms - genetics Protein Isoforms - physiology Receptor, Fibroblast Growth Factor, Type 2 - physiology Sex Sex determination Sex Determination Processes - genetics Sex reversal Signal transduction Signaling Sox9 protein Testes Testis - embryology Testis - metabolism Wnt protein Wnt4 Protein - genetics
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