Virus entry and replication in the brain precedes blood-brain barrier disruption during intranasal alphavirus infection

Abstract Viral infections of the central nervous system (CNS) are often associated with blood-brain barrier (BBB) disruption, yet the impact of virus replication and immune cell recruitment on BBB integrity are incompletely understood. Using two-photon microscopy, we demonstrate that Venezuelan equi...

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Veröffentlicht in:	Journal of neuroimmunology 2017-07, Vol.308, p.118-130
Hauptverfasser:	Cain, Matthew D, Salimi, Hamid, Gong, Yongfeng, Yang, Lihua, Hamilton, Samantha L, Heffernan, James R, Hou, Jianghui, Miller, Mark J, Klein, Robyn S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Protein Complex 1 - genetics Adaptor Protein Complex 1 - metabolism Allergy and Immunology Alphavirus Infections - genetics Alphavirus Infections - pathology Animals Animals, Newborn Blood-Brain Barrier - physiopathology Blood-Brain Barrier - ultrastructure Blood-Brain Barrier - virology Brain - metabolism Brain - virology Capillary Permeability - physiology Cells, Cultured Cerebral Cortex - cytology Cricetinae CX3C Chemokine Receptor 1 Disease Models, Animal Encephalitis Virus, Venezuelan Equine - physiology Epithelial Cells - drug effects Epithelial Cells - physiology Epithelial Cells - ultrastructure Epithelial Cells - virology Gene Expression Regulation - physiology Mice Mice, Inbred C57BL Mice, Transgenic Neurology Receptors, Chemokine - genetics Receptors, Chemokine - metabolism Tumor Necrosis Factor-alpha - pharmacology Virus Internalization Virus Replication - physiology
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