GABA concentrations in the anterior temporal lobe predict human semantic processing
There is now considerable convergent evidence from multiple methodologies and clinical studies that the human anterior temporal lobe (ATL) is a semantic representational hub. However, the neurochemical nature of the ATL in the semantic processing remains unclear. The current study investigated the n...
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| Veröffentlicht in: | Scientific reports 2017-11, Vol.7 (1), p.15748-9, Article 15748 |
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| description | There is now considerable convergent evidence from multiple methodologies and clinical studies that the human anterior temporal lobe (ATL) is a semantic representational hub. However, the neurochemical nature of the ATL in the semantic processing remains unclear. The current study investigated the neurochemical mechanism underlying semantic processing in the ATL. We combined functional magnetic resonance imaging (fMRI) with resting-state magnetic resonance spectroscopy (MRS) to measure task-related blood-oxygen level-dependent (BOLD) signal changes during sematic processing and resting-state GABA concentrations in the ATL. Our combined fMRI and MRS investigation showed that the stronger ATL BOLD response induced by the semantic task, the lower GABA concentration in the same region. Moreover, individuals with higher GABA concentration in the ATL showed better semantic performance and stronger BOLD-related fluctuations in the semantic network. Our data demonstrated that the resting-state GABA concentration predicts neural changes in the human ATL and task performance during semantic processing. Our findings indicate that individuals with higher GABA may have a more efficient semantic processing leading to better task performance and imply that GABAergic neurochemical processes are potentially crucial to the neurobiological contribution of the ATL to semantic cognition. |
| doi_str_mv | 10.1038/s41598-017-15981-7 |
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However, the neurochemical nature of the ATL in the semantic processing remains unclear. The current study investigated the neurochemical mechanism underlying semantic processing in the ATL. We combined functional magnetic resonance imaging (fMRI) with resting-state magnetic resonance spectroscopy (MRS) to measure task-related blood-oxygen level-dependent (BOLD) signal changes during sematic processing and resting-state GABA concentrations in the ATL. Our combined fMRI and MRS investigation showed that the stronger ATL BOLD response induced by the semantic task, the lower GABA concentration in the same region. Moreover, individuals with higher GABA concentration in the ATL showed better semantic performance and stronger BOLD-related fluctuations in the semantic network. Our data demonstrated that the resting-state GABA concentration predicts neural changes in the human ATL and task performance during semantic processing. Our findings indicate that individuals with higher GABA may have a more efficient semantic processing leading to better task performance and imply that GABAergic neurochemical processes are potentially crucial to the neurobiological contribution of the ATL to semantic cognition.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-017-15981-7</identifier><identifier>PMID: 29146995</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>140/131 ; 59/36 ; 59/57 ; 631/378/2649/1594 ; 631/477/2811 ; Adult ; Brain Mapping ; Cognition ; Cognition - physiology ; Female ; Functional magnetic resonance imaging ; gamma-Aminobutyric Acid - metabolism ; Humanities and Social Sciences ; Humans ; Information processing ; Magnetic Resonance Imaging ; Magnetic resonance spectroscopy ; Male ; multidisciplinary ; Science ; Science (multidisciplinary) ; Semantics ; Spectroscopy ; Temporal lobe ; Temporal Lobe - diagnostic imaging ; Temporal Lobe - metabolism ; γ-Aminobutyric acid</subject><ispartof>Scientific reports, 2017-11, Vol.7 (1), p.15748-9, Article 15748</ispartof><rights>The Author(s) 2017</rights><rights>Copyright Nature Publishing Group Nov 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-d45577922abf576ee65aeea8443da0f08617041846580eea78d19fc3225abd133</citedby><cites>FETCH-LOGICAL-c474t-d45577922abf576ee65aeea8443da0f08617041846580eea78d19fc3225abd133</cites><orcidid>0000-0001-5907-2488 ; 0000-0001-5940-1675</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691052/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691052/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29146995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jung, JeYoung</creatorcontrib><creatorcontrib>Williams, Stephen R.</creatorcontrib><creatorcontrib>Sanaei Nezhad, Faezeh</creatorcontrib><creatorcontrib>Lambon Ralph, Matthew A.</creatorcontrib><title>GABA concentrations in the anterior temporal lobe predict human semantic processing</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>There is now considerable convergent evidence from multiple methodologies and clinical studies that the human anterior temporal lobe (ATL) is a semantic representational hub. However, the neurochemical nature of the ATL in the semantic processing remains unclear. The current study investigated the neurochemical mechanism underlying semantic processing in the ATL. We combined functional magnetic resonance imaging (fMRI) with resting-state magnetic resonance spectroscopy (MRS) to measure task-related blood-oxygen level-dependent (BOLD) signal changes during sematic processing and resting-state GABA concentrations in the ATL. Our combined fMRI and MRS investigation showed that the stronger ATL BOLD response induced by the semantic task, the lower GABA concentration in the same region. Moreover, individuals with higher GABA concentration in the ATL showed better semantic performance and stronger BOLD-related fluctuations in the semantic network. Our data demonstrated that the resting-state GABA concentration predicts neural changes in the human ATL and task performance during semantic processing. Our findings indicate that individuals with higher GABA may have a more efficient semantic processing leading to better task performance and imply that GABAergic neurochemical processes are potentially crucial to the neurobiological contribution of the ATL to semantic cognition.</description><subject>140/131</subject><subject>59/36</subject><subject>59/57</subject><subject>631/378/2649/1594</subject><subject>631/477/2811</subject><subject>Adult</subject><subject>Brain Mapping</subject><subject>Cognition</subject><subject>Cognition - physiology</subject><subject>Female</subject><subject>Functional magnetic resonance imaging</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Information processing</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic resonance spectroscopy</subject><subject>Male</subject><subject>multidisciplinary</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Semantics</subject><subject>Spectroscopy</subject><subject>Temporal lobe</subject><subject>Temporal Lobe - diagnostic imaging</subject><subject>Temporal Lobe - metabolism</subject><subject>γ-Aminobutyric acid</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1UU1rHSEUldLShDR_oIsidNPNJOr4MW4CL6H5gEAXbdfic-68Z5jRF3UK_ff1ZdLwGqgLvXjOPdfjQegjJWeUtN155lToriFUNfuCNuoNOmaEi4a1jL09qI_Qac4PpC7BNKf6PTpimnKptThG329WlyvsYnAQSrLFx5CxD7hsAdtQIPmYcIFpF5Md8RjXgHcJeu8K3s6TDThD3Yt39To6yNmHzQf0brBjhtPn8wT9vP764-q2uf92c3e1um8cV7w0PRdCKc2YXQ9CSQApLIDtOG97SwbSSaoIpx2XoiMVUF1P9eCqI2HXPW3bE3Sx6O7m9QT94mA0u-Qnm36baL35Fwl-azbxlxFS0_oZVeDLs0CKjzPkYiafHYyjDRDnbKiWkrWas_2sz6-oD3FOodrbswSVtJW6stjCcinmnGB4eQwlZh-bWWIzNTbzFJtRtenToY2Xlr8hVUK7EHKFwgbSwez_y_4B1EOjYg</recordid><startdate>20171116</startdate><enddate>20171116</enddate><creator>Jung, JeYoung</creator><creator>Williams, Stephen R.</creator><creator>Sanaei Nezhad, Faezeh</creator><creator>Lambon Ralph, Matthew A.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5907-2488</orcidid><orcidid>https://orcid.org/0000-0001-5940-1675</orcidid></search><sort><creationdate>20171116</creationdate><title>GABA concentrations in the anterior temporal lobe predict human semantic processing</title><author>Jung, JeYoung ; Williams, Stephen R. ; Sanaei Nezhad, Faezeh ; Lambon Ralph, Matthew A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-d45577922abf576ee65aeea8443da0f08617041846580eea78d19fc3225abd133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>140/131</topic><topic>59/36</topic><topic>59/57</topic><topic>631/378/2649/1594</topic><topic>631/477/2811</topic><topic>Adult</topic><topic>Brain Mapping</topic><topic>Cognition</topic><topic>Cognition - physiology</topic><topic>Female</topic><topic>Functional magnetic resonance imaging</topic><topic>gamma-Aminobutyric Acid - metabolism</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Information processing</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetic resonance spectroscopy</topic><topic>Male</topic><topic>multidisciplinary</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Semantics</topic><topic>Spectroscopy</topic><topic>Temporal lobe</topic><topic>Temporal Lobe - diagnostic imaging</topic><topic>Temporal Lobe - metabolism</topic><topic>γ-Aminobutyric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jung, JeYoung</creatorcontrib><creatorcontrib>Williams, Stephen R.</creatorcontrib><creatorcontrib>Sanaei Nezhad, Faezeh</creatorcontrib><creatorcontrib>Lambon Ralph, Matthew A.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jung, JeYoung</au><au>Williams, Stephen R.</au><au>Sanaei Nezhad, Faezeh</au><au>Lambon Ralph, Matthew A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GABA concentrations in the anterior temporal lobe predict human semantic processing</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-11-16</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>15748</spage><epage>9</epage><pages>15748-9</pages><artnum>15748</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>There is now considerable convergent evidence from multiple methodologies and clinical studies that the human anterior temporal lobe (ATL) is a semantic representational hub. However, the neurochemical nature of the ATL in the semantic processing remains unclear. The current study investigated the neurochemical mechanism underlying semantic processing in the ATL. We combined functional magnetic resonance imaging (fMRI) with resting-state magnetic resonance spectroscopy (MRS) to measure task-related blood-oxygen level-dependent (BOLD) signal changes during sematic processing and resting-state GABA concentrations in the ATL. Our combined fMRI and MRS investigation showed that the stronger ATL BOLD response induced by the semantic task, the lower GABA concentration in the same region. Moreover, individuals with higher GABA concentration in the ATL showed better semantic performance and stronger BOLD-related fluctuations in the semantic network. Our data demonstrated that the resting-state GABA concentration predicts neural changes in the human ATL and task performance during semantic processing. Our findings indicate that individuals with higher GABA may have a more efficient semantic processing leading to better task performance and imply that GABAergic neurochemical processes are potentially crucial to the neurobiological contribution of the ATL to semantic cognition.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29146995</pmid><doi>10.1038/s41598-017-15981-7</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5907-2488</orcidid><orcidid>https://orcid.org/0000-0001-5940-1675</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 140/131 59/36 59/57 631/378/2649/1594 631/477/2811 Adult Brain Mapping Cognition Cognition - physiology Female Functional magnetic resonance imaging gamma-Aminobutyric Acid - metabolism Humanities and Social Sciences Humans Information processing Magnetic Resonance Imaging Magnetic resonance spectroscopy Male multidisciplinary Science Science (multidisciplinary) Semantics Spectroscopy Temporal lobe Temporal Lobe - diagnostic imaging Temporal Lobe - metabolism γ-Aminobutyric acid |
| title | GABA concentrations in the anterior temporal lobe predict human semantic processing |
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