The androgen receptor is a negative regulator of eIF4E phosphorylation at S209: implications for the use of mTOR inhibitors in advanced prostate cancer

The antiandrogen bicalutamide is widely used in the treatment of advanced prostate cancer (PCa) in many countries, but its effect on castration-resistant PCa (CRPC) is limited. We previously showed that resistance to bicalutamide results from activation of mechanistic target of rapamycin (mTOR). Int...

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Veröffentlicht in:	Oncogene 2017-11, Vol.36 (46), p.6359-6373
Hauptverfasser:	D'Abronzo, L S, Bose, S, Crapuchettes, M E, Beggs, R E, Vinall, R L, Tepper, C G, Siddiqui, S, Mudryj, M, Melgoza, F U, Durbin-Johnson, B P, deVere White, R W, Ghosh, P M
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/105 13/106 13/109 13/2 13/31 13/51 13/89 13/95 631/67/1059/602 631/67/589/466 Analysis Androgen receptors Androgen suppression therapy Androgens Anilides - administration & dosage Aniline Compounds - administration & dosage Animal models Animals Antagonists Antiandrogens Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis Blotting, Western Cancer surgery Care and treatment Castration Cell Biology Cell Line, Tumor Cell proliferation Clinical trials Development and progression Diagnosis Dosage and administration Eukaryotic Initiation Factor-4E - metabolism Everolimus - administration & dosage Extracellular signal-regulated kinase Gene expression Genetic aspects Health aspects Human Genetics Humans Initiation factor eIF-4E Internal Medicine Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Intracellular Signaling Peptides and Proteins - metabolism Kinases Male MAP kinase Medicine Medicine & Public Health Mice, Nude Nitriles - administration & dosage Oncology original-article Phosphorylation Phosphorylation - drug effects Phosphotransferases Prostate cancer Prostatectomy Prostatic Neoplasms, Castration-Resistant - drug therapy Prostatic Neoplasms, Castration-Resistant - metabolism Protein kinase Protein kinases Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Purines - administration & dosage Rapamycin Receptors, Androgen - metabolism Serine - metabolism siRNA Sirolimus - administration & dosage Survivin Threonine TOR protein TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism Tosyl Compounds - administration & dosage Transcription Transcription factors Tumors Urological surgery Xenograft Model Antitumor Assays Xenografts
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