Triptan-induced latent sensitization: A possible basis for medication overuse headache

Objective Identification of the neural mechanisms underlying medication overuse headache resulting from triptans. Methods Triptans were administered systemically to rats by repeated intermittent injections or by continuous infusion over 6 days. Periorbital and hind paw sensory thresholds were measur...

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Veröffentlicht in:	Annals of neurology 2010-03, Vol.67 (3), p.325-337
Hauptverfasser:	De Felice, Milena, Ossipov, Michael H., Wang, Ruizhong, Lai, Josephine, Chichorro, Juliana, Meng, Ian, Dodick, David W., Vanderah, Todd W., Dussor, Gregory, Porreca, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcitonin Gene-Related Peptide - analysis Calcitonin Gene-Related Peptide - blood Drug Administration Schedule Drug toxicity and drugs side effects treatment Dura Mater - physiopathology Enzyme-Linked Immunosorbent Assay Fluorescent Antibody Technique Headache Disorders, Secondary - physiopathology Hyperalgesia - chemically induced Hyperalgesia - physiopathology Male Medical sciences Migraine Disorders - drug therapy Neurology Nitric Oxide Donors - pharmacology Nociceptors - drug effects Nociceptors - physiology Pain Measurement Pain Threshold - drug effects Pain Threshold - physiology Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Reaction Time - drug effects Reaction Time - physiology Sensory Receptor Cells - drug effects Sensory Receptor Cells - physiology Time Factors Toxicity: nervous system and muscle Trigeminal Nerve - drug effects Trigeminal Nerve - physiopathology Tryptamines - adverse effects Tryptamines - toxicity
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