Use of dual-energy computed tomography to measure skeletal-wide marrow composition and cancellous bone mineral density
Temporal and spatial variations in bone marrow adipose tissue (MAT) can be indicative of several pathologies and confound current methods of assessing immediate changes in bone mineral remodeling. We present a novel dual-energy computed tomography (DECT) method to monitor MAT and marrow-corrected vo...
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| Veröffentlicht in: | Journal of bone and mineral metabolism 2017-07, Vol.35 (4), p.428-436 |
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| creator | Arentsen, Luke Hansen, Karen E. Yagi, Masashi Takahashi, Yutaka Shanley, Ryan McArthur, Angela Bolan, Patrick Magome, Taiki Yee, Douglas Froelich, Jerry Hui, Susanta K. |
| description | Temporal and spatial variations in bone marrow adipose tissue (MAT) can be indicative of several pathologies and confound current methods of assessing immediate changes in bone mineral remodeling. We present a novel dual-energy computed tomography (DECT) method to monitor MAT and marrow-corrected volumetric BMD (mcvBMD) throughout the body. Twenty-three cancellous skeletal sites in 20 adult female cadavers aged 40–80 years old were measured using DECT (80 and 140 kVp). vBMD was simultaneous recorded using QCT. MAT was further sampled using MRI. Thirteen lumbar vertebrae were then excised from the MRI-imaged donors and examined by microCT. After MAT correction throughout the skeleton, significant differences (
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| doi_str_mv | 10.1007/s00774-016-0796-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5689468</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1914770426</sourcerecordid><originalsourceid>FETCH-LOGICAL-c494t-67fa98d98f2bf10d7f5822e563702e61b43b93abd3b2689809d068cac0edeeec3</originalsourceid><addsrcrecordid>eNp1kUFrFTEUhYMo9ln9AW4k4MZNNMlkkslGkGJVKLix65BJ7rxOnUmeyUzL-_fe11dLFdwkgfvdk3M4hLwW_L3g3HyoeBjFuNCMG6uZeEI2QjUtazVXT8mGW6FYZ4w9IS9qveZcmNaI5-REGqukNXZDbi4r0DzQuPqJQYKy3dOQ5926QKRLnvO2-N3VHp90Bl_XArT-hAkWxG_HCHT2peTbu51cx2XMifoUafApwDTltdI-J8RG1PYTjZCQ2r8kzwY_VXh1f5-Sy_PPP86-sovvX76dfbpgQVm1MG0Gb7tou0H2g-DRDG0nJbS6MVyCFr1qetv4Pja91J3tuI1cd8EHDhEAQnNKPh51d2s_QwyQFnThdmVE33uX_ej-nqTxym3zjWtRTukOBd7dC5T8a4W6uHmsh2Q-AYZzomul1rIxCtG3_6DXeS0J4zmBRRjDldRIiSMVSq61wPBgRnB3aNUdW3XYqju06gTuvHmc4mHjT40IyCNQcZS2UB59_V_V3zQOsMk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1914770426</pqid></control><display><type>article</type><title>Use of dual-energy computed tomography to measure skeletal-wide marrow composition and cancellous bone mineral density</title><source>MEDLINE</source><source>SpringerLink (Online service)</source><creator>Arentsen, Luke ; Hansen, Karen E. ; Yagi, Masashi ; Takahashi, Yutaka ; Shanley, Ryan ; McArthur, Angela ; Bolan, Patrick ; Magome, Taiki ; Yee, Douglas ; Froelich, Jerry ; Hui, Susanta K.</creator><creatorcontrib>Arentsen, Luke ; Hansen, Karen E. ; Yagi, Masashi ; Takahashi, Yutaka ; Shanley, Ryan ; McArthur, Angela ; Bolan, Patrick ; Magome, Taiki ; Yee, Douglas ; Froelich, Jerry ; Hui, Susanta K.</creatorcontrib><description>Temporal and spatial variations in bone marrow adipose tissue (MAT) can be indicative of several pathologies and confound current methods of assessing immediate changes in bone mineral remodeling. We present a novel dual-energy computed tomography (DECT) method to monitor MAT and marrow-corrected volumetric BMD (mcvBMD) throughout the body. Twenty-three cancellous skeletal sites in 20 adult female cadavers aged 40–80 years old were measured using DECT (80 and 140 kVp). vBMD was simultaneous recorded using QCT. MAT was further sampled using MRI. Thirteen lumbar vertebrae were then excised from the MRI-imaged donors and examined by microCT. After MAT correction throughout the skeleton, significant differences (
p
< 0.05) were found between QCT-derived vBMD and DECT-derived mcvBMD results. McvBMD was highly heterogeneous with a maximum at the posterior skull and minimum in the proximal humerus (574 and 0.7 mg/cc, respectively). BV/TV and BMC have a nearly significant correlation with mcvBMD (
r
= 0.545,
p
= 0.057 and
r
= 0.539,
p
= 0.061, respectively). MAT assessed by DECT showed a significant correlation with MRI MAT results (
r
= 0.881,
p
< 0.0001). Both DECT- and MRI-derived MAT had a significant influence on uncorrected vBMD (
r
= −0.86 and
r
= −0.818,
p
≤ 0.0001, respectively). Conversely, mcvBMD had no correlation with DECT- or MRI-derived MAT (
r
= 0.261 and
r
= 0.067). DECT can be used to assess MAT while simultaneously collecting mcvBMD values at each skeletal site. MAT is heterogeneous throughout the skeleton, highly variable, and should be accounted for in longitudinal mcvBMD studies. McvBMD accurately reflects the calcified tissue in cancellous bone.</description><identifier>ISSN: 0914-8779</identifier><identifier>EISSN: 1435-5604</identifier><identifier>DOI: 10.1007/s00774-016-0796-1</identifier><identifier>PMID: 27942979</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Adipose tissue ; Adipose Tissue - diagnostic imaging ; Adiposity ; Adult ; Aged ; Aged, 80 and over ; Bone composition ; Bone Density - physiology ; Bone marrow ; Bone Marrow - diagnostic imaging ; Bone mineral density ; Bone remodeling ; Cadaver ; Cadavers ; Cancellous bone ; Cancellous Bone - diagnostic imaging ; Cancellous Bone - physiology ; Computed tomography ; Female ; Humans ; Humerus ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Original Article ; Orthopedics ; Skeleton ; Skull ; Spatial variations ; Spine ; Tomography ; Tomography, X-Ray Computed - methods ; Vertebrae ; X-Ray Microtomography</subject><ispartof>Journal of bone and mineral metabolism, 2017-07, Vol.35 (4), p.428-436</ispartof><rights>The Japanese Society for Bone and Mineral Research and Springer Japan 2016</rights><rights>Journal of Bone and Mineral Metabolism is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-67fa98d98f2bf10d7f5822e563702e61b43b93abd3b2689809d068cac0edeeec3</citedby><cites>FETCH-LOGICAL-c494t-67fa98d98f2bf10d7f5822e563702e61b43b93abd3b2689809d068cac0edeeec3</cites><orcidid>0000-0002-1394-3724</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00774-016-0796-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00774-016-0796-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27942979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arentsen, Luke</creatorcontrib><creatorcontrib>Hansen, Karen E.</creatorcontrib><creatorcontrib>Yagi, Masashi</creatorcontrib><creatorcontrib>Takahashi, Yutaka</creatorcontrib><creatorcontrib>Shanley, Ryan</creatorcontrib><creatorcontrib>McArthur, Angela</creatorcontrib><creatorcontrib>Bolan, Patrick</creatorcontrib><creatorcontrib>Magome, Taiki</creatorcontrib><creatorcontrib>Yee, Douglas</creatorcontrib><creatorcontrib>Froelich, Jerry</creatorcontrib><creatorcontrib>Hui, Susanta K.</creatorcontrib><title>Use of dual-energy computed tomography to measure skeletal-wide marrow composition and cancellous bone mineral density</title><title>Journal of bone and mineral metabolism</title><addtitle>J Bone Miner Metab</addtitle><addtitle>J Bone Miner Metab</addtitle><description>Temporal and spatial variations in bone marrow adipose tissue (MAT) can be indicative of several pathologies and confound current methods of assessing immediate changes in bone mineral remodeling. We present a novel dual-energy computed tomography (DECT) method to monitor MAT and marrow-corrected volumetric BMD (mcvBMD) throughout the body. Twenty-three cancellous skeletal sites in 20 adult female cadavers aged 40–80 years old were measured using DECT (80 and 140 kVp). vBMD was simultaneous recorded using QCT. MAT was further sampled using MRI. Thirteen lumbar vertebrae were then excised from the MRI-imaged donors and examined by microCT. After MAT correction throughout the skeleton, significant differences (
p
< 0.05) were found between QCT-derived vBMD and DECT-derived mcvBMD results. McvBMD was highly heterogeneous with a maximum at the posterior skull and minimum in the proximal humerus (574 and 0.7 mg/cc, respectively). BV/TV and BMC have a nearly significant correlation with mcvBMD (
r
= 0.545,
p
= 0.057 and
r
= 0.539,
p
= 0.061, respectively). MAT assessed by DECT showed a significant correlation with MRI MAT results (
r
= 0.881,
p
< 0.0001). Both DECT- and MRI-derived MAT had a significant influence on uncorrected vBMD (
r
= −0.86 and
r
= −0.818,
p
≤ 0.0001, respectively). Conversely, mcvBMD had no correlation with DECT- or MRI-derived MAT (
r
= 0.261 and
r
= 0.067). DECT can be used to assess MAT while simultaneously collecting mcvBMD values at each skeletal site. MAT is heterogeneous throughout the skeleton, highly variable, and should be accounted for in longitudinal mcvBMD studies. McvBMD accurately reflects the calcified tissue in cancellous bone.</description><subject>Adipose tissue</subject><subject>Adipose Tissue - diagnostic imaging</subject><subject>Adiposity</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bone composition</subject><subject>Bone Density - physiology</subject><subject>Bone marrow</subject><subject>Bone Marrow - diagnostic imaging</subject><subject>Bone mineral density</subject><subject>Bone remodeling</subject><subject>Cadaver</subject><subject>Cadavers</subject><subject>Cancellous bone</subject><subject>Cancellous Bone - diagnostic imaging</subject><subject>Cancellous Bone - physiology</subject><subject>Computed tomography</subject><subject>Female</subject><subject>Humans</subject><subject>Humerus</subject><subject>Imaging, Three-Dimensional</subject><subject>Magnetic Resonance Imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Skeleton</subject><subject>Skull</subject><subject>Spatial variations</subject><subject>Spine</subject><subject>Tomography</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Vertebrae</subject><subject>X-Ray Microtomography</subject><issn>0914-8779</issn><issn>1435-5604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kUFrFTEUhYMo9ln9AW4k4MZNNMlkkslGkGJVKLix65BJ7rxOnUmeyUzL-_fe11dLFdwkgfvdk3M4hLwW_L3g3HyoeBjFuNCMG6uZeEI2QjUtazVXT8mGW6FYZ4w9IS9qveZcmNaI5-REGqukNXZDbi4r0DzQuPqJQYKy3dOQ5926QKRLnvO2-N3VHp90Bl_XArT-hAkWxG_HCHT2peTbu51cx2XMifoUafApwDTltdI-J8RG1PYTjZCQ2r8kzwY_VXh1f5-Sy_PPP86-sovvX76dfbpgQVm1MG0Gb7tou0H2g-DRDG0nJbS6MVyCFr1qetv4Pja91J3tuI1cd8EHDhEAQnNKPh51d2s_QwyQFnThdmVE33uX_ej-nqTxym3zjWtRTukOBd7dC5T8a4W6uHmsh2Q-AYZzomul1rIxCtG3_6DXeS0J4zmBRRjDldRIiSMVSq61wPBgRnB3aNUdW3XYqju06gTuvHmc4mHjT40IyCNQcZS2UB59_V_V3zQOsMk</recordid><startdate>20170701</startdate><enddate>20170701</enddate><creator>Arentsen, Luke</creator><creator>Hansen, Karen E.</creator><creator>Yagi, Masashi</creator><creator>Takahashi, Yutaka</creator><creator>Shanley, Ryan</creator><creator>McArthur, Angela</creator><creator>Bolan, Patrick</creator><creator>Magome, Taiki</creator><creator>Yee, Douglas</creator><creator>Froelich, Jerry</creator><creator>Hui, Susanta K.</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1394-3724</orcidid></search><sort><creationdate>20170701</creationdate><title>Use of dual-energy computed tomography to measure skeletal-wide marrow composition and cancellous bone mineral density</title><author>Arentsen, Luke ; Hansen, Karen E. ; Yagi, Masashi ; Takahashi, Yutaka ; Shanley, Ryan ; McArthur, Angela ; Bolan, Patrick ; Magome, Taiki ; Yee, Douglas ; Froelich, Jerry ; Hui, Susanta K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-67fa98d98f2bf10d7f5822e563702e61b43b93abd3b2689809d068cac0edeeec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adipose tissue</topic><topic>Adipose Tissue - diagnostic imaging</topic><topic>Adiposity</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bone composition</topic><topic>Bone Density - physiology</topic><topic>Bone marrow</topic><topic>Bone Marrow - diagnostic imaging</topic><topic>Bone mineral density</topic><topic>Bone remodeling</topic><topic>Cadaver</topic><topic>Cadavers</topic><topic>Cancellous bone</topic><topic>Cancellous Bone - diagnostic imaging</topic><topic>Cancellous Bone - physiology</topic><topic>Computed tomography</topic><topic>Female</topic><topic>Humans</topic><topic>Humerus</topic><topic>Imaging, Three-Dimensional</topic><topic>Magnetic Resonance Imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Skeleton</topic><topic>Skull</topic><topic>Spatial variations</topic><topic>Spine</topic><topic>Tomography</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Vertebrae</topic><topic>X-Ray Microtomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arentsen, Luke</creatorcontrib><creatorcontrib>Hansen, Karen E.</creatorcontrib><creatorcontrib>Yagi, Masashi</creatorcontrib><creatorcontrib>Takahashi, Yutaka</creatorcontrib><creatorcontrib>Shanley, Ryan</creatorcontrib><creatorcontrib>McArthur, Angela</creatorcontrib><creatorcontrib>Bolan, Patrick</creatorcontrib><creatorcontrib>Magome, Taiki</creatorcontrib><creatorcontrib>Yee, Douglas</creatorcontrib><creatorcontrib>Froelich, Jerry</creatorcontrib><creatorcontrib>Hui, Susanta K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>ProQuest - Health & Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of bone and mineral metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arentsen, Luke</au><au>Hansen, Karen E.</au><au>Yagi, Masashi</au><au>Takahashi, Yutaka</au><au>Shanley, Ryan</au><au>McArthur, Angela</au><au>Bolan, Patrick</au><au>Magome, Taiki</au><au>Yee, Douglas</au><au>Froelich, Jerry</au><au>Hui, Susanta K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of dual-energy computed tomography to measure skeletal-wide marrow composition and cancellous bone mineral density</atitle><jtitle>Journal of bone and mineral metabolism</jtitle><stitle>J Bone Miner Metab</stitle><addtitle>J Bone Miner Metab</addtitle><date>2017-07-01</date><risdate>2017</risdate><volume>35</volume><issue>4</issue><spage>428</spage><epage>436</epage><pages>428-436</pages><issn>0914-8779</issn><eissn>1435-5604</eissn><abstract>Temporal and spatial variations in bone marrow adipose tissue (MAT) can be indicative of several pathologies and confound current methods of assessing immediate changes in bone mineral remodeling. We present a novel dual-energy computed tomography (DECT) method to monitor MAT and marrow-corrected volumetric BMD (mcvBMD) throughout the body. Twenty-three cancellous skeletal sites in 20 adult female cadavers aged 40–80 years old were measured using DECT (80 and 140 kVp). vBMD was simultaneous recorded using QCT. MAT was further sampled using MRI. Thirteen lumbar vertebrae were then excised from the MRI-imaged donors and examined by microCT. After MAT correction throughout the skeleton, significant differences (
p
< 0.05) were found between QCT-derived vBMD and DECT-derived mcvBMD results. McvBMD was highly heterogeneous with a maximum at the posterior skull and minimum in the proximal humerus (574 and 0.7 mg/cc, respectively). BV/TV and BMC have a nearly significant correlation with mcvBMD (
r
= 0.545,
p
= 0.057 and
r
= 0.539,
p
= 0.061, respectively). MAT assessed by DECT showed a significant correlation with MRI MAT results (
r
= 0.881,
p
< 0.0001). Both DECT- and MRI-derived MAT had a significant influence on uncorrected vBMD (
r
= −0.86 and
r
= −0.818,
p
≤ 0.0001, respectively). Conversely, mcvBMD had no correlation with DECT- or MRI-derived MAT (
r
= 0.261 and
r
= 0.067). DECT can be used to assess MAT while simultaneously collecting mcvBMD values at each skeletal site. MAT is heterogeneous throughout the skeleton, highly variable, and should be accounted for in longitudinal mcvBMD studies. McvBMD accurately reflects the calcified tissue in cancellous bone.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>27942979</pmid><doi>10.1007/s00774-016-0796-1</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-1394-3724</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of bone and mineral metabolism, 2017-07, Vol.35 (4), p.428-436 |
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| language | eng |
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| source | MEDLINE; SpringerLink (Online service) |
| subjects | Adipose tissue Adipose Tissue - diagnostic imaging Adiposity Adult Aged Aged, 80 and over Bone composition Bone Density - physiology Bone marrow Bone Marrow - diagnostic imaging Bone mineral density Bone remodeling Cadaver Cadavers Cancellous bone Cancellous Bone - diagnostic imaging Cancellous Bone - physiology Computed tomography Female Humans Humerus Imaging, Three-Dimensional Magnetic Resonance Imaging Medicine Medicine & Public Health Metabolic Diseases Middle Aged Original Article Orthopedics Skeleton Skull Spatial variations Spine Tomography Tomography, X-Ray Computed - methods Vertebrae X-Ray Microtomography |
| title | Use of dual-energy computed tomography to measure skeletal-wide marrow composition and cancellous bone mineral density |
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