Evaluation of glucose utilization capacity of bioactivity-guided fractions of Barleria prionitis Linn and Hyptis suaveolens (L.) Poit in isolated rat hemidiaphragm
Diabetes mellitus (DM) is a chronic disease characterized by high blood glucose levels due to absolute or relative circulating insulin levels. Plants represent a major potential source of drugs for treating diabetes. The study of plants having antidiabetic activity may give a new approach in the tre...
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Veröffentlicht in: | Ayu 2016-04, Vol.37 (2), p.145-150 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Diabetes mellitus (DM) is a chronic disease characterized by high blood glucose levels due to absolute or relative circulating insulin levels. Plants represent a major potential source of drugs for treating diabetes. The study of plants having antidiabetic activity may give a new approach in the treatment of DM.
This study was aimed to investigate the glucose utilization capacity of bioactivity-guided fractions of
and
.
The dried coarse powdered plant material was extracted in aqueous ethanol by cold maceration; further, ethanolic extracts were fractionated using solvents of varying polarity and were investigated in isolated rat hemidiaphragm using 0.1% and 0.2% concentrations of plant extracts.
The tested fractions of both plants showed significant and dose-dependent increased glucose uptake capacity and was found to be maximum with petroleum ether and aqueous ethanolic extracts of both plants; 0.2% concentration of both plant extracts is superior in activity when compared to 0.1% of the test extracts.
has produced more glucose utilization capacity when compared to
.
The activity of
is comparable to standard insulin (
< 0.01). Both the plant materials have some extra pancreatic mechanism like glucose uptake by peripheral tissue. |
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ISSN: | 0974-8520 0976-9382 |
DOI: | 10.4103/ayu.AYU_198_15 |