Evaluation of glucose utilization capacity of bioactivity-guided fractions of Barleria prionitis Linn and Hyptis suaveolens (L.) Poit in isolated rat hemidiaphragm

Diabetes mellitus (DM) is a chronic disease characterized by high blood glucose levels due to absolute or relative circulating insulin levels. Plants represent a major potential source of drugs for treating diabetes. The study of plants having antidiabetic activity may give a new approach in the tre...

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Veröffentlicht in:Ayu 2016-04, Vol.37 (2), p.145-150
Hauptverfasser: Begum, Azmath Unnisa, Venkatesh, Sama, Prakash, Jaya, Alvala, Ravi
Format: Artikel
Sprache:eng
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Zusammenfassung:Diabetes mellitus (DM) is a chronic disease characterized by high blood glucose levels due to absolute or relative circulating insulin levels. Plants represent a major potential source of drugs for treating diabetes. The study of plants having antidiabetic activity may give a new approach in the treatment of DM. This study was aimed to investigate the glucose utilization capacity of bioactivity-guided fractions of and . The dried coarse powdered plant material was extracted in aqueous ethanol by cold maceration; further, ethanolic extracts were fractionated using solvents of varying polarity and were investigated in isolated rat hemidiaphragm using 0.1% and 0.2% concentrations of plant extracts. The tested fractions of both plants showed significant and dose-dependent increased glucose uptake capacity and was found to be maximum with petroleum ether and aqueous ethanolic extracts of both plants; 0.2% concentration of both plant extracts is superior in activity when compared to 0.1% of the test extracts. has produced more glucose utilization capacity when compared to . The activity of is comparable to standard insulin ( < 0.01). Both the plant materials have some extra pancreatic mechanism like glucose uptake by peripheral tissue.
ISSN:0974-8520
0976-9382
DOI:10.4103/ayu.AYU_198_15