Prognostic role of myoferlin expression in patients with clear cell renal cell carcinoma
In patients with cancer, myoferlin protein hyperexpression has been correlated with poor patient prognosis. Here, we evaluated myoferlin expression in patients with clear cell renal cell carcinoma (ccRCC) and investigated the prognostic significance of myoferlin expression in these patients. One hun...
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| Veröffentlicht in: | Oncotarget 2017-10, Vol.8 (51), p.89033-89039 |
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| creator | Song, Dae Hyun Ko, Gyung Hyuck Lee, Jeong Hee Lee, Jong Sil Yang, Jung Wook Kim, Min Hye An, Hyo Jung Kang, Myoung Hee Jeon, Kyung Nyeo Kim, Dong Chul |
| description | In patients with cancer, myoferlin protein hyperexpression has been correlated with poor patient prognosis. Here, we evaluated myoferlin expression in patients with clear cell renal cell carcinoma (ccRCC) and investigated the prognostic significance of myoferlin expression in these patients.
One hundred and fifty-two patients with ccRCC who underwent treatment at Gyeongsang National University Hospital, Korea, between January 2000 and December 2009 were enrolled. Immunohistochemical analysis was performed on tissue microarray blocks produced from surgical specimens. Surgical specimen cancerous cells were graded as showing myoferlin hyperexpression or hypoexpression by comparison with intratumoral endothelial cells. Disease-free survival was evaluated using Kaplan-Meier analysis. Cox regression analysis was used to determine the relationships between myoferlin expression levels, risk factors, and prognosis.
Seventy-one of 304 cores exhibited myoferlin hyperexpression. T stage was not associated with myoferlin hyperexpression, whereas a high Fuhrman nuclear grade was significantly associated with myoferlin hyperexpression. Kaplan-Meier analysis revealed that patients with T stage >2, Fuhrman nuclear grade >2, and those with myoferlin hyperexpression had poorer disease-free survival compared to those with lower T stage, lower Fuhrman nuclear grade, and myoferlin hypoexpression (all p |
| doi_str_mv | 10.18632/oncotarget.21645 |
| format | Article |
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One hundred and fifty-two patients with ccRCC who underwent treatment at Gyeongsang National University Hospital, Korea, between January 2000 and December 2009 were enrolled. Immunohistochemical analysis was performed on tissue microarray blocks produced from surgical specimens. Surgical specimen cancerous cells were graded as showing myoferlin hyperexpression or hypoexpression by comparison with intratumoral endothelial cells. Disease-free survival was evaluated using Kaplan-Meier analysis. Cox regression analysis was used to determine the relationships between myoferlin expression levels, risk factors, and prognosis.
Seventy-one of 304 cores exhibited myoferlin hyperexpression. T stage was not associated with myoferlin hyperexpression, whereas a high Fuhrman nuclear grade was significantly associated with myoferlin hyperexpression. Kaplan-Meier analysis revealed that patients with T stage >2, Fuhrman nuclear grade >2, and those with myoferlin hyperexpression had poorer disease-free survival compared to those with lower T stage, lower Fuhrman nuclear grade, and myoferlin hypoexpression (all p <0.001). Furthermore, myoferlin hyperexpression was significantly associated with disease-free survival on Cox regression analysis (hazard ratio, 4.604; 95% confidence interval, 1.893-11.199; p = 0.001).
Myoferlin expression could be a potential prognosticator in patients with ccRCC, and might be a useful marker for oncologic surveillance in such patients.</description><identifier>ISSN: 1949-2553</identifier><identifier>EISSN: 1949-2553</identifier><identifier>DOI: 10.18632/oncotarget.21645</identifier><identifier>PMID: 29179496</identifier><language>eng</language><publisher>United States: Impact Journals LLC</publisher><subject>Research Paper</subject><ispartof>Oncotarget, 2017-10, Vol.8 (51), p.89033-89039</ispartof><rights>Copyright: © 2017 Song et al. 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-e180da29e313e146f442adc494f48f2abc834fd056437b1a17d78d90f3dcf3253</citedby><cites>FETCH-LOGICAL-c399t-e180da29e313e146f442adc494f48f2abc834fd056437b1a17d78d90f3dcf3253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687666/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687666/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29179496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Dae Hyun</creatorcontrib><creatorcontrib>Ko, Gyung Hyuck</creatorcontrib><creatorcontrib>Lee, Jeong Hee</creatorcontrib><creatorcontrib>Lee, Jong Sil</creatorcontrib><creatorcontrib>Yang, Jung Wook</creatorcontrib><creatorcontrib>Kim, Min Hye</creatorcontrib><creatorcontrib>An, Hyo Jung</creatorcontrib><creatorcontrib>Kang, Myoung Hee</creatorcontrib><creatorcontrib>Jeon, Kyung Nyeo</creatorcontrib><creatorcontrib>Kim, Dong Chul</creatorcontrib><title>Prognostic role of myoferlin expression in patients with clear cell renal cell carcinoma</title><title>Oncotarget</title><addtitle>Oncotarget</addtitle><description>In patients with cancer, myoferlin protein hyperexpression has been correlated with poor patient prognosis. Here, we evaluated myoferlin expression in patients with clear cell renal cell carcinoma (ccRCC) and investigated the prognostic significance of myoferlin expression in these patients.
One hundred and fifty-two patients with ccRCC who underwent treatment at Gyeongsang National University Hospital, Korea, between January 2000 and December 2009 were enrolled. Immunohistochemical analysis was performed on tissue microarray blocks produced from surgical specimens. Surgical specimen cancerous cells were graded as showing myoferlin hyperexpression or hypoexpression by comparison with intratumoral endothelial cells. Disease-free survival was evaluated using Kaplan-Meier analysis. Cox regression analysis was used to determine the relationships between myoferlin expression levels, risk factors, and prognosis.
Seventy-one of 304 cores exhibited myoferlin hyperexpression. T stage was not associated with myoferlin hyperexpression, whereas a high Fuhrman nuclear grade was significantly associated with myoferlin hyperexpression. Kaplan-Meier analysis revealed that patients with T stage >2, Fuhrman nuclear grade >2, and those with myoferlin hyperexpression had poorer disease-free survival compared to those with lower T stage, lower Fuhrman nuclear grade, and myoferlin hypoexpression (all p <0.001). Furthermore, myoferlin hyperexpression was significantly associated with disease-free survival on Cox regression analysis (hazard ratio, 4.604; 95% confidence interval, 1.893-11.199; p = 0.001).
Myoferlin expression could be a potential prognosticator in patients with ccRCC, and might be a useful marker for oncologic surveillance in such patients.</description><subject>Research Paper</subject><issn>1949-2553</issn><issn>1949-2553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpVUU1LAzEQDaLYUvsDvEiOXlo3H5vdXAQpfoGgBwVvIc1O2shuUpOt2n_v2tZa5zIzzHtvZngInZJsTErB6EXwJrQ6zqAdUyJ4foD6RHI5onnODvfqHhqm9JZ1kfOipPIY9agkRTcWffT6FMPMh9Q6g2OoAQeLm1WwEGvnMXwtIqTkgsddt9CtA98m_OnaOTY16IgN1DWO4HW9KY2OxvnQ6BN0ZHWdYLjNA_Ryc_08uRs9PN7eT64eRoZJ2Y6AlFmlqQRGGBAuLOdUV4ZLbnlpqZ6aknFbZbngrJgSTYqqKCuZWVYZy2jOBuhyo7tYThuoTHdg1LVaRNfouFJBO_V_4t1czcKHykVZCCE6gfOtQAzvS0italz6-UV7CMukiBRSUp4L0kHJBmpiSCmC3a0hmVqbov5MUWtTOs7Z_n07xq8F7Buzio1-</recordid><startdate>20171024</startdate><enddate>20171024</enddate><creator>Song, Dae Hyun</creator><creator>Ko, Gyung Hyuck</creator><creator>Lee, Jeong Hee</creator><creator>Lee, Jong Sil</creator><creator>Yang, Jung Wook</creator><creator>Kim, Min Hye</creator><creator>An, Hyo Jung</creator><creator>Kang, Myoung Hee</creator><creator>Jeon, Kyung Nyeo</creator><creator>Kim, Dong Chul</creator><general>Impact Journals LLC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20171024</creationdate><title>Prognostic role of myoferlin expression in patients with clear cell renal cell carcinoma</title><author>Song, Dae Hyun ; Ko, Gyung Hyuck ; Lee, Jeong Hee ; Lee, Jong Sil ; Yang, Jung Wook ; Kim, Min Hye ; An, Hyo Jung ; Kang, Myoung Hee ; Jeon, Kyung Nyeo ; Kim, Dong Chul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-e180da29e313e146f442adc494f48f2abc834fd056437b1a17d78d90f3dcf3253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Research Paper</topic><toplevel>online_resources</toplevel><creatorcontrib>Song, Dae Hyun</creatorcontrib><creatorcontrib>Ko, Gyung Hyuck</creatorcontrib><creatorcontrib>Lee, Jeong Hee</creatorcontrib><creatorcontrib>Lee, Jong Sil</creatorcontrib><creatorcontrib>Yang, Jung Wook</creatorcontrib><creatorcontrib>Kim, Min Hye</creatorcontrib><creatorcontrib>An, Hyo Jung</creatorcontrib><creatorcontrib>Kang, Myoung Hee</creatorcontrib><creatorcontrib>Jeon, Kyung Nyeo</creatorcontrib><creatorcontrib>Kim, Dong Chul</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncotarget</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Dae Hyun</au><au>Ko, Gyung Hyuck</au><au>Lee, Jeong Hee</au><au>Lee, Jong Sil</au><au>Yang, Jung Wook</au><au>Kim, Min Hye</au><au>An, Hyo Jung</au><au>Kang, Myoung Hee</au><au>Jeon, Kyung Nyeo</au><au>Kim, Dong Chul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic role of myoferlin expression in patients with clear cell renal cell carcinoma</atitle><jtitle>Oncotarget</jtitle><addtitle>Oncotarget</addtitle><date>2017-10-24</date><risdate>2017</risdate><volume>8</volume><issue>51</issue><spage>89033</spage><epage>89039</epage><pages>89033-89039</pages><issn>1949-2553</issn><eissn>1949-2553</eissn><abstract>In patients with cancer, myoferlin protein hyperexpression has been correlated with poor patient prognosis. Here, we evaluated myoferlin expression in patients with clear cell renal cell carcinoma (ccRCC) and investigated the prognostic significance of myoferlin expression in these patients.
One hundred and fifty-two patients with ccRCC who underwent treatment at Gyeongsang National University Hospital, Korea, between January 2000 and December 2009 were enrolled. Immunohistochemical analysis was performed on tissue microarray blocks produced from surgical specimens. Surgical specimen cancerous cells were graded as showing myoferlin hyperexpression or hypoexpression by comparison with intratumoral endothelial cells. Disease-free survival was evaluated using Kaplan-Meier analysis. Cox regression analysis was used to determine the relationships between myoferlin expression levels, risk factors, and prognosis.
Seventy-one of 304 cores exhibited myoferlin hyperexpression. T stage was not associated with myoferlin hyperexpression, whereas a high Fuhrman nuclear grade was significantly associated with myoferlin hyperexpression. Kaplan-Meier analysis revealed that patients with T stage >2, Fuhrman nuclear grade >2, and those with myoferlin hyperexpression had poorer disease-free survival compared to those with lower T stage, lower Fuhrman nuclear grade, and myoferlin hypoexpression (all p <0.001). Furthermore, myoferlin hyperexpression was significantly associated with disease-free survival on Cox regression analysis (hazard ratio, 4.604; 95% confidence interval, 1.893-11.199; p = 0.001).
Myoferlin expression could be a potential prognosticator in patients with ccRCC, and might be a useful marker for oncologic surveillance in such patients.</abstract><cop>United States</cop><pub>Impact Journals LLC</pub><pmid>29179496</pmid><doi>10.18632/oncotarget.21645</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| title | Prognostic role of myoferlin expression in patients with clear cell renal cell carcinoma |
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