Expression of ARID1B Is Associated With Poor Outcomes and Predicts the Benefit from Adjuvant Chemotherapy in Bladder Urothelial Carcinoma
ARID1B, which exists as a mutually exclusive isoform with ARID1A in the SWI/SNF chromatin remodeling complex, has been recently identified as a major mutant gene in a wide variety of cancers. The present study aimed to determine the association between ARID1B expression and outcomes, as well as the...
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| Veröffentlicht in: | Journal of Cancer 2017-01, Vol.8 (17), p.3490-3497 |
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| container_issue | 17 |
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| container_title | Journal of Cancer |
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| creator | Wang, Beihe Xie, Huyang Ma, Chunguang Zhang, Guiming Gan, Hualei Wang, Qifeng Liu, Xiaohang Zhu, Yiping Zhu, Yao Shi, Guohai Zhang, Hailiang Dai, Bo Shen, Yijun Ye, Dingwei |
| description | ARID1B, which exists as a mutually exclusive isoform with ARID1A in the SWI/SNF chromatin remodeling complex, has been recently identified as a major mutant gene in a wide variety of cancers. The present study aimed to determine the association between ARID1B expression and outcomes, as well as the benefit from adjuvant chemotherapy in patients with bladder cancer.
Tissue microarrays of 143 consecutively recruited patients with bladder cancer from our center were created. Immunohistochemistry was performed to assess the expression of ARID1B and its association with outcomes. Clinicopathological factors were also evaluated.
ARID1B expression was significantly associated with tumor size (
=0.015), T stage (
=0.027), lymph node status (
=0.030), TNM stage (
=0.040), overall survival ( |
| doi_str_mv | 10.7150/jca.19109 |
| format | Article |
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Tissue microarrays of 143 consecutively recruited patients with bladder cancer from our center were created. Immunohistochemistry was performed to assess the expression of ARID1B and its association with outcomes. Clinicopathological factors were also evaluated.
ARID1B expression was significantly associated with tumor size (
=0.015), T stage (
=0.027), lymph node status (
=0.030), TNM stage (
=0.040), overall survival (
<0.001), and progression-free survival (
=0.043). Furthermore, high expression of ARID1B was an independent indicator of poor OS (
=0.022). The prognostic model containing ARID1B showed a better predictive accuracy than the bench models. Most importantly, the benefit of adjuvant chemotherapy observed in patients with low ARID1B expression was superior to that observed in patients with high ARID1B expression.
Our study suggests that ARID1B can serve as a prognostic biomarker of bladder urothelial carcinoma. Additionally, ARID1B might be a predictive marker for selecting patients for adjuvant chemotherapy in the high-risk subgroup.</description><identifier>ISSN: 1837-9664</identifier><identifier>EISSN: 1837-9664</identifier><identifier>DOI: 10.7150/jca.19109</identifier><identifier>PMID: 29151933</identifier><language>eng</language><publisher>Australia: Ivyspring International Publisher</publisher><subject>Research Paper</subject><ispartof>Journal of Cancer, 2017-01, Vol.8 (17), p.3490-3497</ispartof><rights>Ivyspring International Publisher 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-3db9b377d7078be3f498417dc1b316051f5819967caffd04354ea9ba945525a53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687163/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687163/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29151933$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Beihe</creatorcontrib><creatorcontrib>Xie, Huyang</creatorcontrib><creatorcontrib>Ma, Chunguang</creatorcontrib><creatorcontrib>Zhang, Guiming</creatorcontrib><creatorcontrib>Gan, Hualei</creatorcontrib><creatorcontrib>Wang, Qifeng</creatorcontrib><creatorcontrib>Liu, Xiaohang</creatorcontrib><creatorcontrib>Zhu, Yiping</creatorcontrib><creatorcontrib>Zhu, Yao</creatorcontrib><creatorcontrib>Shi, Guohai</creatorcontrib><creatorcontrib>Zhang, Hailiang</creatorcontrib><creatorcontrib>Dai, Bo</creatorcontrib><creatorcontrib>Shen, Yijun</creatorcontrib><creatorcontrib>Ye, Dingwei</creatorcontrib><title>Expression of ARID1B Is Associated With Poor Outcomes and Predicts the Benefit from Adjuvant Chemotherapy in Bladder Urothelial Carcinoma</title><title>Journal of Cancer</title><addtitle>J Cancer</addtitle><description>ARID1B, which exists as a mutually exclusive isoform with ARID1A in the SWI/SNF chromatin remodeling complex, has been recently identified as a major mutant gene in a wide variety of cancers. The present study aimed to determine the association between ARID1B expression and outcomes, as well as the benefit from adjuvant chemotherapy in patients with bladder cancer.
Tissue microarrays of 143 consecutively recruited patients with bladder cancer from our center were created. Immunohistochemistry was performed to assess the expression of ARID1B and its association with outcomes. Clinicopathological factors were also evaluated.
ARID1B expression was significantly associated with tumor size (
=0.015), T stage (
=0.027), lymph node status (
=0.030), TNM stage (
=0.040), overall survival (
<0.001), and progression-free survival (
=0.043). Furthermore, high expression of ARID1B was an independent indicator of poor OS (
=0.022). The prognostic model containing ARID1B showed a better predictive accuracy than the bench models. Most importantly, the benefit of adjuvant chemotherapy observed in patients with low ARID1B expression was superior to that observed in patients with high ARID1B expression.
Our study suggests that ARID1B can serve as a prognostic biomarker of bladder urothelial carcinoma. Additionally, ARID1B might be a predictive marker for selecting patients for adjuvant chemotherapy in the high-risk subgroup.</description><subject>Research Paper</subject><issn>1837-9664</issn><issn>1837-9664</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpVUctqHDEQFCEhNrYP-YHQx-Swzmg1Go0ugd2N7SwYbExMjqJHj6yWGWkjaUz8CfnrzPqFU5duuorqpouQD7Q6FZRXX7YaT6mklXxDDmnLxEw2Tf32VX9ATnLeVhOYnIuavScHc0k5lYwdkr9nf3bJ5uxjgOhgcbP-RpewzrDIOWqPxRr46csGrmNMcDUWHQebAYOB62SN1yVD2VhY2mCdL-BSHGBhtuMdhgKrjR3iRCfc3YMPsOzRGJvgNu2nvcceVpi0D3HAY_LOYZ_tyVM9IrfnZz9W32eXVxfr1eJyppngZcZMJzsmhBGVaDvLXC3bmgqjacdoU3HqeEulbIRG50xVM15blB3KmvM5R86OyNdH393YDdZoG0rCXu2SHzDdq4he_c8Ev1G_4p3iTStowyaDT08GKf4ebS5q8Fnbvsdg45gV3T99wryZpJ8fpTrFnJN1L2topfbpqSk99ZDepP34-q4X5XNW7B9tdJa-</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Wang, Beihe</creator><creator>Xie, Huyang</creator><creator>Ma, Chunguang</creator><creator>Zhang, Guiming</creator><creator>Gan, Hualei</creator><creator>Wang, Qifeng</creator><creator>Liu, Xiaohang</creator><creator>Zhu, Yiping</creator><creator>Zhu, Yao</creator><creator>Shi, Guohai</creator><creator>Zhang, Hailiang</creator><creator>Dai, Bo</creator><creator>Shen, Yijun</creator><creator>Ye, Dingwei</creator><general>Ivyspring International Publisher</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170101</creationdate><title>Expression of ARID1B Is Associated With Poor Outcomes and Predicts the Benefit from Adjuvant Chemotherapy in Bladder Urothelial Carcinoma</title><author>Wang, Beihe ; Xie, Huyang ; Ma, Chunguang ; Zhang, Guiming ; Gan, Hualei ; Wang, Qifeng ; Liu, Xiaohang ; Zhu, Yiping ; Zhu, Yao ; Shi, Guohai ; Zhang, Hailiang ; Dai, Bo ; Shen, Yijun ; Ye, Dingwei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-3db9b377d7078be3f498417dc1b316051f5819967caffd04354ea9ba945525a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Research Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Beihe</creatorcontrib><creatorcontrib>Xie, Huyang</creatorcontrib><creatorcontrib>Ma, Chunguang</creatorcontrib><creatorcontrib>Zhang, Guiming</creatorcontrib><creatorcontrib>Gan, Hualei</creatorcontrib><creatorcontrib>Wang, Qifeng</creatorcontrib><creatorcontrib>Liu, Xiaohang</creatorcontrib><creatorcontrib>Zhu, Yiping</creatorcontrib><creatorcontrib>Zhu, Yao</creatorcontrib><creatorcontrib>Shi, Guohai</creatorcontrib><creatorcontrib>Zhang, Hailiang</creatorcontrib><creatorcontrib>Dai, Bo</creatorcontrib><creatorcontrib>Shen, Yijun</creatorcontrib><creatorcontrib>Ye, Dingwei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Beihe</au><au>Xie, Huyang</au><au>Ma, Chunguang</au><au>Zhang, Guiming</au><au>Gan, Hualei</au><au>Wang, Qifeng</au><au>Liu, Xiaohang</au><au>Zhu, Yiping</au><au>Zhu, Yao</au><au>Shi, Guohai</au><au>Zhang, Hailiang</au><au>Dai, Bo</au><au>Shen, Yijun</au><au>Ye, Dingwei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of ARID1B Is Associated With Poor Outcomes and Predicts the Benefit from Adjuvant Chemotherapy in Bladder Urothelial Carcinoma</atitle><jtitle>Journal of Cancer</jtitle><addtitle>J Cancer</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>8</volume><issue>17</issue><spage>3490</spage><epage>3497</epage><pages>3490-3497</pages><issn>1837-9664</issn><eissn>1837-9664</eissn><abstract>ARID1B, which exists as a mutually exclusive isoform with ARID1A in the SWI/SNF chromatin remodeling complex, has been recently identified as a major mutant gene in a wide variety of cancers. The present study aimed to determine the association between ARID1B expression and outcomes, as well as the benefit from adjuvant chemotherapy in patients with bladder cancer.
Tissue microarrays of 143 consecutively recruited patients with bladder cancer from our center were created. Immunohistochemistry was performed to assess the expression of ARID1B and its association with outcomes. Clinicopathological factors were also evaluated.
ARID1B expression was significantly associated with tumor size (
=0.015), T stage (
=0.027), lymph node status (
=0.030), TNM stage (
=0.040), overall survival (
<0.001), and progression-free survival (
=0.043). Furthermore, high expression of ARID1B was an independent indicator of poor OS (
=0.022). The prognostic model containing ARID1B showed a better predictive accuracy than the bench models. Most importantly, the benefit of adjuvant chemotherapy observed in patients with low ARID1B expression was superior to that observed in patients with high ARID1B expression.
Our study suggests that ARID1B can serve as a prognostic biomarker of bladder urothelial carcinoma. Additionally, ARID1B might be a predictive marker for selecting patients for adjuvant chemotherapy in the high-risk subgroup.</abstract><cop>Australia</cop><pub>Ivyspring International Publisher</pub><pmid>29151933</pmid><doi>10.7150/jca.19109</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| title | Expression of ARID1B Is Associated With Poor Outcomes and Predicts the Benefit from Adjuvant Chemotherapy in Bladder Urothelial Carcinoma |
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