Calcitonin Gene-Related Peptide Induces HIV-1 Proteasomal Degradation in Mucosal Langerhans Cells

The neuroimmune dialogue between peripheral neurons and Langerhans cells (LCs) within mucosal epithelia protects against incoming pathogens. LCs rapidly internalize human immunodeficiency virus type 1 (HIV-1) upon its sexual transmission and then -infect CD4 T cells. We recently found that the neuro...

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Veröffentlicht in:	Journal of virology 2017-12, Vol.91 (23)
Hauptverfasser:	Bomsel, Morgane, Ganor, Yonatan
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcitonin Gene-Related Peptide - metabolism Calcitonin Gene-Related Peptide - pharmacology CD4-Positive T-Lymphocytes - virology Cells, Cultured HIV-1 - drug effects HIV-1 - physiology Humans Langerhans Cells - drug effects Langerhans Cells - metabolism Langerhans Cells - virology Leukocytes, Mononuclear - virology Lysosomes - metabolism Lysosomes - virology Mucous Membrane - metabolism Proteasome Endopeptidase Complex - metabolism Virus-Cell Interactions
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