A Selective Bottleneck Shapes the Evolutionary Mutant Spectra of Enterovirus A71 during Viral Dissemination in Humans

RNA viruses accumulate mutations to rapidly adapt to environmental changes. Enterovirus A71 (EV-A71) causes various clinical manifestations with occasional severe neurological complications. However, the mechanism by which EV-A71 evolves within the human body is unclear. Utilizing deep sequencing an...

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Veröffentlicht in:	Journal of virology 2017-12, Vol.91 (23)
Hauptverfasser:	Huang, Sheng-Wen, Huang, Yi-Hui, Tsai, Huey-Pin, Kuo, Pin-Hwa, Wang, Shih-Min, Liu, Ching-Chuan, Wang, Jen-Ren
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Capsid Proteins - chemistry Capsid Proteins - genetics Central Nervous System - virology Child Enterovirus A, Human - genetics Enterovirus A, Human - growth & development Enterovirus A, Human - pathogenicity Enterovirus Infections - physiopathology Enterovirus Infections - virology Evolution, Molecular Gastrointestinal Tract - virology Genetic Diversity and Evolution Haplotypes High-Throughput Nucleotide Sequencing Humans Mutation Plasma - virology Quasispecies Respiratory System - virology Retrospective Studies Virus Replication
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