Salivary duct carcinoma: An aggressive salivary gland malignancy with opportunities for targeted therapy
•Salivary duct carcinoma (SDC) is a rare and aggressive salivary malignancy.•Several recent studies have identified common mutations in SDC.•Anti-ErbB2 therapy, androgen deprivation, and immunotherapy deserve further study. Salivary duct carcinoma (SDC) is a rare, aggressive salivary malignancy that...
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| Veröffentlicht in: | Oral oncology 2017-11, Vol.74, p.40-48 |
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| container_title | Oral oncology |
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| creator | Schmitt, Nicole C. Kang, Hyunseok Sharma, Arun |
| description | •Salivary duct carcinoma (SDC) is a rare and aggressive salivary malignancy.•Several recent studies have identified common mutations in SDC.•Anti-ErbB2 therapy, androgen deprivation, and immunotherapy deserve further study.
Salivary duct carcinoma (SDC) is a rare, aggressive salivary malignancy that is often diagnosed at an advanced stage. Previously, little was known about outcomes of this disease due to its rarity. In the past several years, much has been learned about salivary duct carcinoma after publication of outcomes from several large single-institution series and national database searches. Recent studies of genomic alterations have helped elucidate the biology and pathogenesis of this aggressive disease. Here we review outcomes of the disease, effects of treatment, prognostic factors, and genomic alterations in SDC. Studies of targeted therapy and promising future directions are also discussed. |
| doi_str_mv | 10.1016/j.oraloncology.2017.09.008 |
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Salivary duct carcinoma (SDC) is a rare, aggressive salivary malignancy that is often diagnosed at an advanced stage. Previously, little was known about outcomes of this disease due to its rarity. In the past several years, much has been learned about salivary duct carcinoma after publication of outcomes from several large single-institution series and national database searches. Recent studies of genomic alterations have helped elucidate the biology and pathogenesis of this aggressive disease. Here we review outcomes of the disease, effects of treatment, prognostic factors, and genomic alterations in SDC. Studies of targeted therapy and promising future directions are also discussed.</description><subject>Adult</subject><subject>ErbB2</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mutation</subject><subject>Prognosis</subject><subject>Salivary duct carcinoma</subject><subject>Salivary Ducts - pathology</subject><subject>Salivary Gland Neoplasms - diagnostic imaging</subject><subject>Salivary Gland Neoplasms - genetics</subject><subject>Salivary Gland Neoplasms - pathology</subject><subject>Salivary Gland Neoplasms - therapy</subject><subject>Salivary malignancy</subject><subject>Survival Analysis</subject><issn>1368-8375</issn><issn>1879-0593</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv3CAUha2qVZOm_QsV6qobu5fxgCGLSlH6lCJ10ewRhmsPIxtcwBPNvy_RJFG664rXuedezldVHyg0FCj_tG9C1FPwJkxhPDYboF0DsgEQL6pzKjpZA5Pty7JvuahF27Gz6k1KewBglMHr6mwjKZRrOK92v_XkDjoeiV1NJkZH43yY9SW58kSPY8SU3AFJepSNk_aWzOU4eu3Nkdy5vCNhWULMq3fZYSJDiCTrOGJGS_IOo16Ob6tXg54SvntYL6rbb19vr3_UN7--_7y-uqkN225zzXq76ZFylKBbpiWTVAMTcrtpqewH7PnA0YrBUtCUcsp1jwPtQAxCC4HtRfX5ZLus_YzWoM8lK7VEN5fpVdBO_fvi3U6N4aAYF4zzrhh8fDCI4c-KKavZJYNT-TaGNSkqeclOSMGL9PIkNTGkFHF4akNB3ZNSe_WclLonpUCqQqoUv38-6FPpI5oi-HISYEnr4DCqZBx6g9ZFNFnZ4P6nz1-ck7Bw</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>Schmitt, Nicole C.</creator><creator>Kang, Hyunseok</creator><creator>Sharma, Arun</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8038-7783</orcidid></search><sort><creationdate>20171101</creationdate><title>Salivary duct carcinoma: An aggressive salivary gland malignancy with opportunities for targeted therapy</title><author>Schmitt, Nicole C. ; Kang, Hyunseok ; Sharma, Arun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c544t-5bd2be16e90a35a9591a058942319bfeb6f6ed8fd10a11616abef1708f8a88e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>ErbB2</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Mutation</topic><topic>Prognosis</topic><topic>Salivary duct carcinoma</topic><topic>Salivary Ducts - pathology</topic><topic>Salivary Gland Neoplasms - diagnostic imaging</topic><topic>Salivary Gland Neoplasms - genetics</topic><topic>Salivary Gland Neoplasms - pathology</topic><topic>Salivary Gland Neoplasms - therapy</topic><topic>Salivary malignancy</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schmitt, Nicole C.</creatorcontrib><creatorcontrib>Kang, Hyunseok</creatorcontrib><creatorcontrib>Sharma, Arun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oral oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schmitt, Nicole C.</au><au>Kang, Hyunseok</au><au>Sharma, Arun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Salivary duct carcinoma: An aggressive salivary gland malignancy with opportunities for targeted therapy</atitle><jtitle>Oral oncology</jtitle><addtitle>Oral Oncol</addtitle><date>2017-11-01</date><risdate>2017</risdate><volume>74</volume><spage>40</spage><epage>48</epage><pages>40-48</pages><issn>1368-8375</issn><eissn>1879-0593</eissn><abstract>•Salivary duct carcinoma (SDC) is a rare and aggressive salivary malignancy.•Several recent studies have identified common mutations in SDC.•Anti-ErbB2 therapy, androgen deprivation, and immunotherapy deserve further study.
Salivary duct carcinoma (SDC) is a rare, aggressive salivary malignancy that is often diagnosed at an advanced stage. Previously, little was known about outcomes of this disease due to its rarity. In the past several years, much has been learned about salivary duct carcinoma after publication of outcomes from several large single-institution series and national database searches. Recent studies of genomic alterations have helped elucidate the biology and pathogenesis of this aggressive disease. Here we review outcomes of the disease, effects of treatment, prognostic factors, and genomic alterations in SDC. Studies of targeted therapy and promising future directions are also discussed.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>29103750</pmid><doi>10.1016/j.oraloncology.2017.09.008</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8038-7783</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1368-8375 |
| ispartof | Oral oncology, 2017-11, Vol.74, p.40-48 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult ErbB2 Female Humans Male Mutation Prognosis Salivary duct carcinoma Salivary Ducts - pathology Salivary Gland Neoplasms - diagnostic imaging Salivary Gland Neoplasms - genetics Salivary Gland Neoplasms - pathology Salivary Gland Neoplasms - therapy Salivary malignancy Survival Analysis |
| title | Salivary duct carcinoma: An aggressive salivary gland malignancy with opportunities for targeted therapy |
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