PDGFR-modulated miR-23b cluster and miR-125a-5p suppress lung tumorigenesis by targeting multiple components of KRAS and NF-kB pathways

In NSCLC alterations in PDGF receptors are markers of worst prognosis and efficient targeting of these receptors is yet to be achieved. In this study, we explored PDGFR-regulated microRNAs demonstrating that miR-23b cluster and miR-125a-5p are downregulated by increased expression of PDGFR-α or PDGF...

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Veröffentlicht in:	Scientific reports 2017-11, Vol.7 (1), p.15441-14, Article 15441
Hauptverfasser:	Naidu, Srivatsava, Shi, Lei, Magee, Peter, Middleton, Justin D., Laganá, Alessandro, Sahoo, Sudhakar, Leong, Hui Sun, Galvin, Melanie, Frese, Kristopher, Dive, Caroline, Guzzardo, Vincenza, Fassan, Matteo, Garofalo, Michela
Format:	Artikel
Sprache:	eng
Schlagworte:	101/1 13/1 13/2 13/89 14/32 42/47 42/70 631/337/384/331 631/67/1612/1350 692/308/2056 82/80 96/95 Adenocarcinoma AKT2 protein Animals Antineoplastic Agents - pharmacology Carcinogenesis - genetics Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - therapy Chromosome 5 Down-Regulation Drug Resistance, Neoplasm - genetics Gene Expression Regulation, Neoplastic Gene silencing Genetic Therapy Grb2 protein Humanities and Social Sciences Humans Invasiveness IQGAP1 protein K-Ras protein Lung - pathology Lung cancer Lung Neoplasms - genetics Lung Neoplasms - pathology Lung Neoplasms - therapy Male Mice MicroRNAs MicroRNAs - administration & dosage MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miRNA multidisciplinary Multigene Family - genetics NF-κB protein Non-small cell lung carcinoma p53 Protein Platelet-derived growth factor Proto-Oncogene Proteins p21(ras) - metabolism Raf protein Receptors, Platelet-Derived Growth Factor - metabolism Science Science (multidisciplinary) Signal Transduction - genetics Transcription Factor RelA - metabolism Tumor Suppressor Protein p53 - metabolism Tumorigenesis Tumors Xenograft Model Antitumor Assays
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