Loss of NLRX1 Exacerbates Neural Tissue Damage and NF-κB Signaling following Brain Injury

Traumatic and nontraumatic brain injury results from severe disruptions in the cellular microenvironment leading to massive loss of neuronal populations and increased neuroinflammation. The progressive cascade of secondary events, including ischemia, inflammation, excitotoxicity, and free-radical re...

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Veröffentlicht in:	The Journal of immunology (1950) 2017-11, Vol.199 (10), p.3547-3558
Hauptverfasser:	Theus, Michelle H, Brickler, Thomas, Meza, Armand L, Coutermarsh-Ott, Sheryl, Hazy, Amanda, Gris, Denis, Allen, Irving C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneurysm Animal models Animals Apoptosis Brain Brain Injuries - genetics Brain Injuries - immunology Cell Line, Tumor Cellular Microenvironment Cerebral Cortex - immunology Cerebral Cortex - pathology Cortex Excitotoxicity Gene Expression Regulation Humans Hypoxia Hypoxia - genetics Hypoxia - immunology Immune system Inflammation Intracranial Aneurysm - genetics Intracranial Aneurysm - immunology Ischemia Lesions Macrophages Mice Mice, Inbred C57BL Mice, Knockout Microglia Microglia - immunology Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism NF-kappa B - metabolism NF-κB protein Pattern recognition receptors Retrospective Studies Signal Transduction Traumatic brain injury
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