Serum miRNAs miR-23a, 206, and 499 as Potential Biomarkers for Skeletal Muscle Atrophy
Muscle biopsy has long been expected to be replaced by noninvasive biomarkers with diagnostic value and prognostic applications for muscle atrophy. Growing evidence suggests that circulating microRNAs (miRNAs) could act as biomarkers for numerous pathophysiological statuses. In the present study, ou...
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| Veröffentlicht in: | BioMed research international 2017-01, Vol.2017 (2017), p.1-9 |
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| creator | Chen, Xiaoping Liu, Hongju Chen, Shengju Li, Jinglong Li, Wenjiong He, Jian Wang, Jing Wang, Fei Zhang, Peng |
| description | Muscle biopsy has long been expected to be replaced by noninvasive biomarkers with diagnostic value and prognostic applications for muscle atrophy. Growing evidence suggests that circulating microRNAs (miRNAs) could act as biomarkers for numerous pathophysiological statuses. In the present study, our results showed that the serum levels of six muscle-specific miRNAs (miR-1/23a/133/206/208b/499) were all elevated in unloading induced mice. The medium levels of these six muscle-specific miRNAs were all elevated in starvation induced atrophic C2C12 myotubes. Moreover, the serum levels of miR-23a/206/499 were induced in participants after 45 days of head-down bed rest (HDBR). The levels of miR-23a/206/499 were positively correlated with the ratio of soleus volume loss in HDBR participants, indicating that they might represent the process of muscle loss. In conclusion, our results demonstrated that circulating miRNAs could serve as useful biochemical and molecular indicators for muscle atrophy diagnosis and disease progression. |
| doi_str_mv | 10.1155/2017/8361237 |
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Growing evidence suggests that circulating microRNAs (miRNAs) could act as biomarkers for numerous pathophysiological statuses. In the present study, our results showed that the serum levels of six muscle-specific miRNAs (miR-1/23a/133/206/208b/499) were all elevated in unloading induced mice. The medium levels of these six muscle-specific miRNAs were all elevated in starvation induced atrophic C2C12 myotubes. Moreover, the serum levels of miR-23a/206/499 were induced in participants after 45 days of head-down bed rest (HDBR). The levels of miR-23a/206/499 were positively correlated with the ratio of soleus volume loss in HDBR participants, indicating that they might represent the process of muscle loss. In conclusion, our results demonstrated that circulating miRNAs could serve as useful biochemical and molecular indicators for muscle atrophy diagnosis and disease progression.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2017/8361237</identifier><identifier>PMID: 29214178</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Aerospace medicine ; Astronauts ; Atrophy ; Atrophy, Muscular ; Aviation ; Bed rest ; Bioindicators ; Biological markers ; Biomarkers ; Biomedical research ; Biopsy ; Diabetes ; Diagnostic software ; Diagnostic systems ; Environmental health ; Gene expression ; Genetic aspects ; Health aspects ; Immobilization ; Laboratories ; Medicine ; Methods ; MicroRNA ; MicroRNAs ; miRNA ; Muscles ; Musculoskeletal system ; Myotubes ; NMR ; Nuclear magnetic resonance ; Physiology ; Protein synthesis ; Proteins ; RNA sequencing ; Rodents ; Serum levels ; Skeletal muscle ; Training ; Unloading</subject><ispartof>BioMed research international, 2017-01, Vol.2017 (2017), p.1-9</ispartof><rights>Copyright © 2017 Fei Wang et al.</rights><rights>COPYRIGHT 2017 John Wiley & Sons, Inc.</rights><rights>Copyright © 2017 Fei Wang et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2017 Fei Wang et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-1b868a6d7ec14efb3506c096560f0868b688073c18095e999cf1bddf90a9e4e43</citedby><cites>FETCH-LOGICAL-c565t-1b868a6d7ec14efb3506c096560f0868b688073c18095e999cf1bddf90a9e4e43</cites><orcidid>0000-0002-1033-8123 ; 0000-0002-4004-1021</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682897/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682897/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29214178$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Chase, Prescott B.</contributor><creatorcontrib>Chen, Xiaoping</creatorcontrib><creatorcontrib>Liu, Hongju</creatorcontrib><creatorcontrib>Chen, Shengju</creatorcontrib><creatorcontrib>Li, Jinglong</creatorcontrib><creatorcontrib>Li, Wenjiong</creatorcontrib><creatorcontrib>He, Jian</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Wang, Fei</creatorcontrib><creatorcontrib>Zhang, Peng</creatorcontrib><title>Serum miRNAs miR-23a, 206, and 499 as Potential Biomarkers for Skeletal Muscle Atrophy</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Muscle biopsy has long been expected to be replaced by noninvasive biomarkers with diagnostic value and prognostic applications for muscle atrophy. Growing evidence suggests that circulating microRNAs (miRNAs) could act as biomarkers for numerous pathophysiological statuses. In the present study, our results showed that the serum levels of six muscle-specific miRNAs (miR-1/23a/133/206/208b/499) were all elevated in unloading induced mice. The medium levels of these six muscle-specific miRNAs were all elevated in starvation induced atrophic C2C12 myotubes. Moreover, the serum levels of miR-23a/206/499 were induced in participants after 45 days of head-down bed rest (HDBR). The levels of miR-23a/206/499 were positively correlated with the ratio of soleus volume loss in HDBR participants, indicating that they might represent the process of muscle loss. In conclusion, our results demonstrated that circulating miRNAs could serve as useful biochemical and molecular indicators for muscle atrophy diagnosis and disease progression.</description><subject>Aerospace medicine</subject><subject>Astronauts</subject><subject>Atrophy</subject><subject>Atrophy, Muscular</subject><subject>Aviation</subject><subject>Bed rest</subject><subject>Bioindicators</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Biomedical research</subject><subject>Biopsy</subject><subject>Diabetes</subject><subject>Diagnostic software</subject><subject>Diagnostic systems</subject><subject>Environmental health</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Immobilization</subject><subject>Laboratories</subject><subject>Medicine</subject><subject>Methods</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>miRNA</subject><subject>Muscles</subject><subject>Musculoskeletal system</subject><subject>Myotubes</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Physiology</subject><subject>Protein synthesis</subject><subject>Proteins</subject><subject>RNA sequencing</subject><subject>Rodents</subject><subject>Serum levels</subject><subject>Skeletal 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miRNAs miR-23a, 206, and 499 as Potential Biomarkers for Skeletal Muscle Atrophy</title><author>Chen, Xiaoping ; Liu, Hongju ; Chen, Shengju ; Li, Jinglong ; Li, Wenjiong ; He, Jian ; Wang, Jing ; Wang, Fei ; Zhang, Peng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c565t-1b868a6d7ec14efb3506c096560f0868b688073c18095e999cf1bddf90a9e4e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aerospace medicine</topic><topic>Astronauts</topic><topic>Atrophy</topic><topic>Atrophy, Muscular</topic><topic>Aviation</topic><topic>Bed rest</topic><topic>Bioindicators</topic><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Biomedical research</topic><topic>Biopsy</topic><topic>Diabetes</topic><topic>Diagnostic software</topic><topic>Diagnostic systems</topic><topic>Environmental health</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Health 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Potential Biomarkers for Skeletal Muscle Atrophy</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>2017</volume><issue>2017</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Muscle biopsy has long been expected to be replaced by noninvasive biomarkers with diagnostic value and prognostic applications for muscle atrophy. Growing evidence suggests that circulating microRNAs (miRNAs) could act as biomarkers for numerous pathophysiological statuses. In the present study, our results showed that the serum levels of six muscle-specific miRNAs (miR-1/23a/133/206/208b/499) were all elevated in unloading induced mice. The medium levels of these six muscle-specific miRNAs were all elevated in starvation induced atrophic C2C12 myotubes. Moreover, the serum levels of miR-23a/206/499 were induced in participants after 45 days of head-down bed rest (HDBR). The levels of miR-23a/206/499 were positively correlated with the ratio of soleus volume loss in HDBR participants, indicating that they might represent the process of muscle loss. In conclusion, our results demonstrated that circulating miRNAs could serve as useful biochemical and molecular indicators for muscle atrophy diagnosis and disease progression.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>29214178</pmid><doi>10.1155/2017/8361237</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-1033-8123</orcidid><orcidid>https://orcid.org/0000-0002-4004-1021</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aerospace medicine Astronauts Atrophy Atrophy, Muscular Aviation Bed rest Bioindicators Biological markers Biomarkers Biomedical research Biopsy Diabetes Diagnostic software Diagnostic systems Environmental health Gene expression Genetic aspects Health aspects Immobilization Laboratories Medicine Methods MicroRNA MicroRNAs miRNA Muscles Musculoskeletal system Myotubes NMR Nuclear magnetic resonance Physiology Protein synthesis Proteins RNA sequencing Rodents Serum levels Skeletal muscle Training Unloading |
| title | Serum miRNAs miR-23a, 206, and 499 as Potential Biomarkers for Skeletal Muscle Atrophy |
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