Involvement of galanin and galanin receptor 1 in nociceptive modulation in the central nucleus of amygdala in normal and neuropathic rats
The present study was performed to explore the role of galanin and galanin receptor 1 (GalR 1) in nociceptive modulation in the central nucleus of amygdala (CeA) in normal rats and rats with neuropathy, and the involvement of GalR 1 and PKC was also investigated. The hindpaw withdrawal latencies (HW...
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| Veröffentlicht in: | Scientific reports 2017-11, Vol.7 (1), p.15317-10, Article 15317 |
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| description | The present study was performed to explore the role of galanin and galanin receptor 1 (GalR 1) in nociceptive modulation in the central nucleus of amygdala (CeA) in normal rats and rats with neuropathy, and the involvement of GalR 1 and PKC was also investigated. The hindpaw withdrawal latencies (HWLs) to thermal and mechanical stimulations were increased in a dose-dependent manner after intra-CeA injection of galanin in both normal rats and rats with neuropathy. The increased HWLs were significantly attenuated by intra-CeA injection of galanin receptor antagonist M40, indicating an involvement of galanin receptor in nociceptive modulation in CeA. Furthermore, intra-CeA administration of the GalR 1 agonist M 617 induced increases in HWLs in normal rats, suggesting that GalR 1 may be involved in galanin-induce antinociception in CeA. Additionally, intra-CeA injection of the PKC inhibitor inhibited galanin-induced antinociception, showing an involvement of PKC in galanin-induced antinociception in CeA of normal rats. Moreover, there was a significant increase in GalR1 content in CeA in rats with neuropathy than that in normal rats. These results illustrated that galanin induced antinociception in CeA in normal rats and rats with neuropathy, and there is an up-regulation of GalR1 expression in rats with neuropathy. |
| doi_str_mv | 10.1038/s41598-017-13944-6 |
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The hindpaw withdrawal latencies (HWLs) to thermal and mechanical stimulations were increased in a dose-dependent manner after intra-CeA injection of galanin in both normal rats and rats with neuropathy. The increased HWLs were significantly attenuated by intra-CeA injection of galanin receptor antagonist M40, indicating an involvement of galanin receptor in nociceptive modulation in CeA. Furthermore, intra-CeA administration of the GalR 1 agonist M 617 induced increases in HWLs in normal rats, suggesting that GalR 1 may be involved in galanin-induce antinociception in CeA. Additionally, intra-CeA injection of the PKC inhibitor inhibited galanin-induced antinociception, showing an involvement of PKC in galanin-induced antinociception in CeA of normal rats. Moreover, there was a significant increase in GalR1 content in CeA in rats with neuropathy than that in normal rats. These results illustrated that galanin induced antinociception in CeA in normal rats and rats with neuropathy, and there is an up-regulation of GalR1 expression in rats with neuropathy.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-017-13944-6</identifier><identifier>PMID: 29127424</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>38/77 ; 631/378/2629 ; 692/617 ; 82 ; Amygdala ; Animals ; Bradykinin - analogs & derivatives ; Bradykinin - pharmacology ; Central Amygdaloid Nucleus - metabolism ; Central Amygdaloid Nucleus - pathology ; Central Amygdaloid Nucleus - physiopathology ; Galanin ; Galanin - analogs & derivatives ; Galanin - antagonists & inhibitors ; Galanin - metabolism ; Galanin - pharmacology ; GLP-1 receptor agonists ; Humanities and Social Sciences ; Injection ; Male ; multidisciplinary ; Neuralgia - drug therapy ; Neuralgia - metabolism ; Neuralgia - pathology ; Neuralgia - physiopathology ; Neuropathy ; Nociception - drug effects ; Pain perception ; Peptide Fragments - pharmacology ; Protein kinase C ; Rats ; Rats, Sprague-Dawley ; Receptor, Galanin, Type 1 - metabolism ; Rodents ; Science ; Science (multidisciplinary)</subject><ispartof>Scientific reports, 2017-11, Vol.7 (1), p.15317-10, Article 15317</ispartof><rights>The Author(s) 2017</rights><rights>2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-9c6c83aa9d9ad9e6cb4ea3e8ccfaf4ea2bfbdc13fe297d1baa418163d38bb1a63</citedby><cites>FETCH-LOGICAL-c474t-9c6c83aa9d9ad9e6cb4ea3e8ccfaf4ea2bfbdc13fe297d1baa418163d38bb1a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681679/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681679/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29127424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Shi-Yang</creatorcontrib><creatorcontrib>Huo, Mei-Ling</creatorcontrib><creatorcontrib>Wu, Xu-Yang</creatorcontrib><creatorcontrib>Huang, Yu-Qing</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Zhang, Xin</creatorcontrib><creatorcontrib>Jiang, Yan-Mei</creatorcontrib><creatorcontrib>Zhang, Meng-Lin</creatorcontrib><creatorcontrib>Wang, Lin-Lin</creatorcontrib><creatorcontrib>Yu, Long-Chuan</creatorcontrib><title>Involvement of galanin and galanin receptor 1 in nociceptive modulation in the central nucleus of amygdala in normal and neuropathic rats</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The present study was performed to explore the role of galanin and galanin receptor 1 (GalR 1) in nociceptive modulation in the central nucleus of amygdala (CeA) in normal rats and rats with neuropathy, and the involvement of GalR 1 and PKC was also investigated. The hindpaw withdrawal latencies (HWLs) to thermal and mechanical stimulations were increased in a dose-dependent manner after intra-CeA injection of galanin in both normal rats and rats with neuropathy. The increased HWLs were significantly attenuated by intra-CeA injection of galanin receptor antagonist M40, indicating an involvement of galanin receptor in nociceptive modulation in CeA. Furthermore, intra-CeA administration of the GalR 1 agonist M 617 induced increases in HWLs in normal rats, suggesting that GalR 1 may be involved in galanin-induce antinociception in CeA. Additionally, intra-CeA injection of the PKC inhibitor inhibited galanin-induced antinociception, showing an involvement of PKC in galanin-induced antinociception in CeA of normal rats. Moreover, there was a significant increase in GalR1 content in CeA in rats with neuropathy than that in normal rats. These results illustrated that galanin induced antinociception in CeA in normal rats and rats with neuropathy, and there is an up-regulation of GalR1 expression in rats with neuropathy.</description><subject>38/77</subject><subject>631/378/2629</subject><subject>692/617</subject><subject>82</subject><subject>Amygdala</subject><subject>Animals</subject><subject>Bradykinin - analogs & derivatives</subject><subject>Bradykinin - pharmacology</subject><subject>Central Amygdaloid Nucleus - metabolism</subject><subject>Central Amygdaloid Nucleus - pathology</subject><subject>Central Amygdaloid Nucleus - physiopathology</subject><subject>Galanin</subject><subject>Galanin - analogs & derivatives</subject><subject>Galanin - antagonists & inhibitors</subject><subject>Galanin - metabolism</subject><subject>Galanin - pharmacology</subject><subject>GLP-1 receptor agonists</subject><subject>Humanities and Social Sciences</subject><subject>Injection</subject><subject>Male</subject><subject>multidisciplinary</subject><subject>Neuralgia - drug therapy</subject><subject>Neuralgia - metabolism</subject><subject>Neuralgia - pathology</subject><subject>Neuralgia - physiopathology</subject><subject>Neuropathy</subject><subject>Nociception - drug effects</subject><subject>Pain perception</subject><subject>Peptide Fragments - pharmacology</subject><subject>Protein kinase C</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptor, Galanin, Type 1 - metabolism</subject><subject>Rodents</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc9u1DAQxi0EolXpC3BAlrhwSfG_TeILEqqAVqrEBc7WxJ7sukrsxU5W6iPw1jhkWS1I-OIZzTc_z_gj5DVnN5zJ9n1WfKPbivGm4lIrVdXPyKVgalMJKcTzs_iCXOf8yMrZCK24fkkuhOaiUUJdkp_34RCHA44YJhp7uoUBgg8UgjvFCS3up5gopyUL0fol9wekY3TzAJOPYalMO6S2cBIMNMx2wDkvSBiftq6g1uY0lupCDzinuIdp5y1NMOVX5EUPQ8br431Fvn_-9O32rnr4-uX-9uNDZVWjpkrb2rYSQDsNTmNtO4UgsbW2h76Eous7Z7nsUejG8Q5A8ZbX0sm26zjU8op8WLn7uRvRHQc2--RHSE8mgjd_V4LfmW08mE1dOI0ugHdHQIo_ZsyTGX22OJTPwjhnw3UtRcNazYr07T_SxzinUNZbVKJmSktRVGJV2RRzTtifhuHMLGab1WxTzDa_zTbLGm_O1zi1_LG2COQqyKUUtpjO3v4_9hcjQLmo</recordid><startdate>20171110</startdate><enddate>20171110</enddate><creator>Li, Shi-Yang</creator><creator>Huo, Mei-Ling</creator><creator>Wu, Xu-Yang</creator><creator>Huang, Yu-Qing</creator><creator>Wang, Lei</creator><creator>Zhang, Xin</creator><creator>Jiang, Yan-Mei</creator><creator>Zhang, Meng-Lin</creator><creator>Wang, Lin-Lin</creator><creator>Yu, Long-Chuan</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20171110</creationdate><title>Involvement of galanin and galanin receptor 1 in nociceptive modulation in the central nucleus of amygdala in normal and neuropathic rats</title><author>Li, Shi-Yang ; Huo, Mei-Ling ; Wu, Xu-Yang ; Huang, Yu-Qing ; Wang, Lei ; Zhang, Xin ; Jiang, Yan-Mei ; Zhang, Meng-Lin ; Wang, Lin-Lin ; Yu, Long-Chuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-9c6c83aa9d9ad9e6cb4ea3e8ccfaf4ea2bfbdc13fe297d1baa418163d38bb1a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>38/77</topic><topic>631/378/2629</topic><topic>692/617</topic><topic>82</topic><topic>Amygdala</topic><topic>Animals</topic><topic>Bradykinin - analogs & derivatives</topic><topic>Bradykinin - pharmacology</topic><topic>Central Amygdaloid Nucleus - metabolism</topic><topic>Central Amygdaloid Nucleus - pathology</topic><topic>Central Amygdaloid Nucleus - physiopathology</topic><topic>Galanin</topic><topic>Galanin - analogs & derivatives</topic><topic>Galanin - antagonists & inhibitors</topic><topic>Galanin - metabolism</topic><topic>Galanin - pharmacology</topic><topic>GLP-1 receptor agonists</topic><topic>Humanities and Social Sciences</topic><topic>Injection</topic><topic>Male</topic><topic>multidisciplinary</topic><topic>Neuralgia - drug therapy</topic><topic>Neuralgia - metabolism</topic><topic>Neuralgia - pathology</topic><topic>Neuralgia - physiopathology</topic><topic>Neuropathy</topic><topic>Nociception - drug effects</topic><topic>Pain perception</topic><topic>Peptide Fragments - pharmacology</topic><topic>Protein kinase C</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptor, Galanin, Type 1 - metabolism</topic><topic>Rodents</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Shi-Yang</creatorcontrib><creatorcontrib>Huo, Mei-Ling</creatorcontrib><creatorcontrib>Wu, Xu-Yang</creatorcontrib><creatorcontrib>Huang, Yu-Qing</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Zhang, Xin</creatorcontrib><creatorcontrib>Jiang, Yan-Mei</creatorcontrib><creatorcontrib>Zhang, Meng-Lin</creatorcontrib><creatorcontrib>Wang, Lin-Lin</creatorcontrib><creatorcontrib>Yu, Long-Chuan</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Shi-Yang</au><au>Huo, Mei-Ling</au><au>Wu, Xu-Yang</au><au>Huang, Yu-Qing</au><au>Wang, Lei</au><au>Zhang, Xin</au><au>Jiang, Yan-Mei</au><au>Zhang, Meng-Lin</au><au>Wang, Lin-Lin</au><au>Yu, Long-Chuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of galanin and galanin receptor 1 in nociceptive modulation in the central nucleus of amygdala in normal and neuropathic rats</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-11-10</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>15317</spage><epage>10</epage><pages>15317-10</pages><artnum>15317</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The present study was performed to explore the role of galanin and galanin receptor 1 (GalR 1) in nociceptive modulation in the central nucleus of amygdala (CeA) in normal rats and rats with neuropathy, and the involvement of GalR 1 and PKC was also investigated. The hindpaw withdrawal latencies (HWLs) to thermal and mechanical stimulations were increased in a dose-dependent manner after intra-CeA injection of galanin in both normal rats and rats with neuropathy. The increased HWLs were significantly attenuated by intra-CeA injection of galanin receptor antagonist M40, indicating an involvement of galanin receptor in nociceptive modulation in CeA. Furthermore, intra-CeA administration of the GalR 1 agonist M 617 induced increases in HWLs in normal rats, suggesting that GalR 1 may be involved in galanin-induce antinociception in CeA. Additionally, intra-CeA injection of the PKC inhibitor inhibited galanin-induced antinociception, showing an involvement of PKC in galanin-induced antinociception in CeA of normal rats. Moreover, there was a significant increase in GalR1 content in CeA in rats with neuropathy than that in normal rats. These results illustrated that galanin induced antinociception in CeA in normal rats and rats with neuropathy, and there is an up-regulation of GalR1 expression in rats with neuropathy.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29127424</pmid><doi>10.1038/s41598-017-13944-6</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 38/77 631/378/2629 692/617 82 Amygdala Animals Bradykinin - analogs & derivatives Bradykinin - pharmacology Central Amygdaloid Nucleus - metabolism Central Amygdaloid Nucleus - pathology Central Amygdaloid Nucleus - physiopathology Galanin Galanin - analogs & derivatives Galanin - antagonists & inhibitors Galanin - metabolism Galanin - pharmacology GLP-1 receptor agonists Humanities and Social Sciences Injection Male multidisciplinary Neuralgia - drug therapy Neuralgia - metabolism Neuralgia - pathology Neuralgia - physiopathology Neuropathy Nociception - drug effects Pain perception Peptide Fragments - pharmacology Protein kinase C Rats Rats, Sprague-Dawley Receptor, Galanin, Type 1 - metabolism Rodents Science Science (multidisciplinary) |
| title | Involvement of galanin and galanin receptor 1 in nociceptive modulation in the central nucleus of amygdala in normal and neuropathic rats |
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