Upregulation of microRNA-4417 and Its Target Genes Contribute to Nickel Chloride-promoted Lung Epithelial Cell Fibrogenesis and Tumorigenesis

Nickel compounds have been classified as carcinogens and shown to be associated with induction of epithelial-mesenchymal transition (EMT) in fibrogenesis and tumorigenesis, as well as the crucial role of microRNAs (miRNAs) and their related genes in controlling EMT and cancer metastasis. Thus, the m...

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Veröffentlicht in:	Scientific reports 2017-11, Vol.7 (1), p.15320-13, Article 15320
Hauptverfasser:	Wu, Chih-Hsien, Hsiao, Yi-Min, Yeh, Kun-Tu, Tsou, Tsui-Chun, Chen, Chih-Yi, Wu, Ming-Fang, Ko, Jiunn-Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/51 38/61 38/90 631/67/69 631/80/84/2176 64/60 82/80 Cancer Carcinogens Cell Line, Transformed Cell Transformation, Neoplastic - chemically induced Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology E-cadherin Epithelial cells Epithelial Cells - metabolism Epithelial Cells - pathology Fibronectin Fibrosis Humanities and Social Sciences Humans Intravenous administration Lung - metabolism Lung - pathology Lung cancer Lung Neoplasms - chemically induced Lung Neoplasms - metabolism Lung Neoplasms - pathology Lungs Mesenchyme Metastases MicroRNAs - metabolism miRNA multidisciplinary Nickel Nickel - toxicity Nickel chloride Oral administration Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology Respiratory Mucosa - metabolism Respiratory Mucosa - pathology RNA, Neoplasm - metabolism Science Science (multidisciplinary) Transformed cells Tumorigenesis
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