Divergent effects of Wnt/β-catenin signaling modifiers on the preservation of human limbal epithelial progenitors according to culture condition

Wnt signaling plays an important role in the regulation of self-renewal in stem cells. Here we investigated the effect of CHIR99021, the primary transducer of the Wnt signaling canonical pathway, and IWP2, a wide action Wnt signal blocker, on the growth and differentiation of the limbal epithelial p...

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Veröffentlicht in:	Scientific reports 2017-11, Vol.7 (1), p.15241-11, Article 15241
Hauptverfasser:	Lee, Hyun Jung, Wolosin, J. Mario, Chung, So-Hyang
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/100 13/106 631/136/2441 692/308/2171 Antigens, Differentiation - metabolism beta Catenin - metabolism Biopsy Calcium Cell culture Cell Culture Techniques Cell self-renewal Embryos Epithelium, Corneal - cytology Epithelium, Corneal - metabolism Explants Female Growth rate Humanities and Social Sciences Humans Limbus Corneae - cytology Limbus Corneae - metabolism Localization Male multidisciplinary Preservation Progenitor cells Pyridines - pharmacology Pyrimidines - pharmacology Science Science (multidisciplinary) Stem cells Stem Cells - cytology Stem Cells - metabolism Transplantation Wnt protein Wnt Signaling Pathway - drug effects β-Catenin
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