The role of 5‐HT2B receptors in mitral valvulopathy: bone marrow mobilization of endothelial progenitors

Background and Purpose Valvular heart disease (VHD) is highly prevalent in industrialized countries. Chronic use of anorexigens, amphetamine or ergot derivatives targeting the 5‐HT system is associated with VHD. Here, we investigated the contribution of 5‐HT receptors in a model of valve degeneratio...

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Veröffentlicht in:	British journal of pharmacology 2017-11, Vol.174 (22), p.4123-4139
Hauptverfasser:	Ayme‐Dietrich, Estelle, Lawson, Roland, Côté, Francine, Tapia, Claudia, Da Silva, Sylvia, Ebel, Claudine, Hechler, Béatrice, Gachet, Christian, Guyonnet, Jérome, Rouillard, Hélène, Stoltz, Jordane, Quentin, Emily, Banas, Sophie, Daubeuf, François, Frossard, Nelly, Gasser, Bernard, Mazzucotelli, Jean‐Philippe, Hermine, Olivier, Maroteaux, Luc, Monassier, Laurent
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamines Bone marrow Bone marrow transplantation CD34 antigen Cell density Coronary artery disease Degeneration Echocardiography Ergot Extracellular matrix Flow cytometry Heart diseases Hemodynamics Immunocytochemistry Lesions Mimicry Mitral valve Osteoprogenitor cells Research Paper Research Papers Rodents Serotonin S2 receptors Transgenic mice Transplantation
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