CD10−/ALDH− cells are the sole cisplatin-resistant component of a novel ovarian cancer stem cell hierarchy

It is long established that tumour-initiating cancer stem cells (CSCs) possess chemoresistant properties. However, little is known of the mechanisms involved, particularly with respect to the organisation of CSCs as stem-progenitor-differentiated cell hierarchies. Here we aimed to elucidate the rela...

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Veröffentlicht in:	Cell death & disease 2017-10, Vol.8 (10), p.e3128-e3128
Hauptverfasser:	Ffrench, Brendan, Gasch, Claudia, Hokamp, Karsten, Spillane, Cathy, Blackshields, Gordon, Mahgoub, Thamir Mahmoud, Bates, Mark, Kehoe, Louise, Mooney, Aoibhinn, Doyle, Ronan, Doyle, Brendan, O'Donnell, Dearbhaile, Gleeson, Noreen, Hennessy, Bryan T, Stordal, Britta, O'Riain, Ciaran, Lambkin, Helen, O'Toole, Sharon, O'Leary, John J, Gallagher, Michael F
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/31 13/51 38/39 38/61 64/60 692/699/67/1059/2326 692/699/67/1059/99 692/699/67/1517/1709 692/699/67/71 Aldehyde dehydrogenase Antibodies Biochemistry Cell Biology Cell Culture Chemoresistance Chemotherapy Cisplatin DNA damage DNA repair Immunology Life Sciences Original original-article Ovarian cancer Paclitaxel Stem cells Tumors
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