Murine Th17 cells utilize IL-2 receptor gamma chain cytokines but are resistant to cytokine withdrawal-induced apoptosis

Adoptive cellular therapy (ACT) with the Th17 subset of CD4 + T cells can cure established melanoma in preclinical models and holds promise for treating human cancer. However, little is known about the growth factors necessary for optimal engraftment and anti-tumor activity of Th17 cells. Due to the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2017-06, Vol.66 (6), p.737-751
Hauptverfasser:	Neitzke, Daniel J., Bowers, Jacob S., Andrijauskaite, Kristina, O’Connell, Nathaniel S., Garrett-Mayer, Elizabeth, Wrangle, John, Li, Zihai, Paulos, Chrystal M., Cole, David J., Rubinstein, Mark P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive transfer Animal models Animals Antineoplastic Agents - pharmacology Antitumor agents Apoptosis Apoptosis - drug effects Cancer Cancer Research CD4 antigen CD4-Positive T-Lymphocytes - immunology CD8 antigen Cell Proliferation - drug effects Cytokines Depletion Gene Expression Regulation - drug effects Growth factors Helper cells Immunology Immunotherapy, Adoptive Interleukin 15 Interleukin 2 Interleukin 2 receptors Interleukin 7 Interleukin Receptor Common gamma Subunit - immunology Interleukin Receptor Common gamma Subunit - metabolism Interleukin-15 - pharmacology Interleukin-2 - pharmacology Interleukin-7 - pharmacology Lymphocytes Lymphocytes T Medicine Medicine & Public Health Melanoma Melanoma, Experimental - immunology Melanoma, Experimental - pathology Melanoma, Experimental - prevention & control Mice Oncology Original Article Supplements Th17 Cells - immunology Th17 Cells - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!