Longitudinal CSF biomarkers in patients with early Parkinson disease and healthy controls

OBJECTIVE:To analyze longitudinal levels of CSF biomarkers in drug-naive patients with Parkinson disease (PD) and healthy controls (HC), examine the extent to which these biomarker changes relate to clinical measures of PD, and identify what may influence them. METHODS:CSF α-synuclein (α-syn), total...

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Veröffentlicht in:	Neurology 2017-11, Vol.89 (19), p.1959-1969
Hauptverfasser:	Mollenhauer, Brit, Caspell-Garcia, Chelsea J, Coffey, Christopher S, Taylor, Peggy, Shaw, Leslie M, Trojanowski, John Q, Singleton, Andy, Frasier, Mark, Marek, Kenneth, Galasko, Douglas
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Amyloid beta-Peptides - cerebrospinal fluid Apolipoproteins E - genetics Case-Control Studies Dopamine - metabolism Female Humans Longitudinal Studies Male Middle Aged Parkinson Disease - cerebrospinal fluid Parkinson Disease - diagnostic imaging Parkinson Disease - genetics Peptide Fragments - cerebrospinal fluid Polymorphism, Single Nucleotide - genetics Retrospective Studies Severity of Illness Index tau Proteins - cerebrospinal fluid Time Factors Tomography, Emission-Computed, Single-Photon
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