Nitric Oxide: The Forgotten Child of Tumor Metabolism
Nitric oxide (NO) is a signaling molecule with pleiotropic physiological roles in normal cells and pathophysiological roles in cancer. NO synthetase expression and NO synthesis are linked to altered metabolism, neoplasticity, invasiveness, chemoresistance, immune evasion, and ultimately to poor prog...
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| Veröffentlicht in: | Trends in Cancer 2017-09, Vol.3 (9), p.659-672 |
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| creator | Salimian Rizi, Bahar Achreja, Abhinav Nagrath, Deepak |
| description | Nitric oxide (NO) is a signaling molecule with pleiotropic physiological roles in normal cells and pathophysiological roles in cancer. NO synthetase expression and NO synthesis are linked to altered metabolism, neoplasticity, invasiveness, chemoresistance, immune evasion, and ultimately to poor prognosis of cancer patients. Exogenous NO in the microenvironment facilitates paracrine signaling, mediates immune responses, and triggers angiogenesis. NO regulates posttranslational protein modifications, S-nitrosation, and genome-wide epigenetic modifications that can have both tumor-promoting and tumor-suppressing effects. We review mechanisms that link NO to cancer hallmarks, with a perspective of co-targeting NO metabolism with first-line therapies for improved outcome. We highlight the need for quantitative flux analysis to study NO in tumors. |
| doi_str_mv | 10.1016/j.trecan.2017.07.005 |
| format | Article |
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| ispartof | Trends in Cancer, 2017-09, Vol.3 (9), p.659-672 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Energy Metabolism Epigenesis, Genetic Gene Expression Regulation, Neoplastic Humans Immunity Immunomodulation Neoplasms - etiology Neoplasms - metabolism Neoplasms - pathology Nitric Oxide - metabolism Nitric Oxide Synthase - metabolism Nitrosation Reactive Oxygen Species Tumor Microenvironment - immunology |
| title | Nitric Oxide: The Forgotten Child of Tumor Metabolism |
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