miR-29a associates with viro-immunological markers of HIV infection in treatment experienced patients
MicroRNAs (miRNAs) are small, non‐coding RNA species essential for the post‐translational regulation of gene expression. Several miRNA have been proposed to contribute to Human immunodeficiency virus‐1 (HIV‐1) infection establishment, progression and latency. Among them, miR‐29a seems to be of parti...
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| Veröffentlicht in: | Journal of medical virology 2016-12, Vol.88 (12), p.2132-2137 |
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| container_title | Journal of medical virology |
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| creator | Rosca, Adelina Anton, Gabriela Botezatu, Anca Temereanca, Aura Ene, Luminita Achim, Cristian Ruta, Simona |
| description | MicroRNAs (miRNAs) are small, non‐coding RNA species essential for the post‐translational regulation of gene expression. Several miRNA have been proposed to contribute to Human immunodeficiency virus‐1 (HIV‐1) infection establishment, progression and latency. Among them, miR‐29a seems to be of particular interest. The aim of this study was to investigate the association between miR‐29a expression and immunologic and virologic markers of HIV infection progression in long‐term antiretroviral‐treated individuals. In a homogenous group of 165 young adults, with chronic HIV infection, parenterally acquired during childhood, the expression level of miR‐29a was found to be inversely correlated with HIV viral load and the degree of immunosuppression, expressed by both CD4 cell count and the CD4/CD8 ratio. There was a significant difference in miR‐29a expression according to the patient's response to treatment, with the lowest levels expressed by patients with treatment failure, defined as detectable viremia and CD4 |
| doi_str_mv | 10.1002/jmv.24586 |
| format | Article |
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Several miRNA have been proposed to contribute to Human immunodeficiency virus‐1 (HIV‐1) infection establishment, progression and latency. Among them, miR‐29a seems to be of particular interest. The aim of this study was to investigate the association between miR‐29a expression and immunologic and virologic markers of HIV infection progression in long‐term antiretroviral‐treated individuals. In a homogenous group of 165 young adults, with chronic HIV infection, parenterally acquired during childhood, the expression level of miR‐29a was found to be inversely correlated with HIV viral load and the degree of immunosuppression, expressed by both CD4 cell count and the CD4/CD8 ratio. There was a significant difference in miR‐29a expression according to the patient's response to treatment, with the lowest levels expressed by patients with treatment failure, defined as detectable viremia and CD4 < 350 cells/mm3. No significant correlation was found between miRNA level and the nadir CD4 count or zenith HIV viral load. This study establishes the association between miR‐29a expression and markers of HIV infection in long‐term survivors, treatment‐experienced patients, suggesting its potential use as an indicator for the on‐treatment disease evolution. J. Med. Virol. 88:2132–2137, 2016. © 2016 Wiley Periodicals, Inc.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.24586</identifier><identifier>PMID: 27232693</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Antiretroviral Therapy, Highly Active ; antiretroviral treatment ; Biomarkers - blood ; CD4 Lymphocyte Count ; CD4-CD8 Ratio ; CD4/CD8 ; Disease Progression ; Female ; Gene expression ; Genetic markers ; HIV ; HIV Infections - drug therapy ; HIV Infections - genetics ; HIV Infections - immunology ; HIV Infections - physiopathology ; HIV-1 - genetics ; Human immunodeficiency virus ; Humans ; Lentivirus ; Male ; microRNA ; MicroRNAs ; MicroRNAs - blood ; MicroRNAs - genetics ; miR-29a ; Retroviridae ; RNA, Viral - blood ; Treatment Failure ; Treatment Outcome ; Viral Load ; Virology ; Young Adult</subject><ispartof>Journal of medical virology, 2016-12, Vol.88 (12), p.2132-2137</ispartof><rights>2016 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5846-81d17319cac854e0aa12455c4a14338ff785d7a8c2a04127f746cd8a498027723</citedby><cites>FETCH-LOGICAL-c5846-81d17319cac854e0aa12455c4a14338ff785d7a8c2a04127f746cd8a498027723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.24586$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.24586$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27232693$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosca, Adelina</creatorcontrib><creatorcontrib>Anton, Gabriela</creatorcontrib><creatorcontrib>Botezatu, Anca</creatorcontrib><creatorcontrib>Temereanca, Aura</creatorcontrib><creatorcontrib>Ene, Luminita</creatorcontrib><creatorcontrib>Achim, Cristian</creatorcontrib><creatorcontrib>Ruta, Simona</creatorcontrib><title>miR-29a associates with viro-immunological markers of HIV infection in treatment experienced patients</title><title>Journal of medical virology</title><addtitle>J. Med. Virol</addtitle><description>MicroRNAs (miRNAs) are small, non‐coding RNA species essential for the post‐translational regulation of gene expression. Several miRNA have been proposed to contribute to Human immunodeficiency virus‐1 (HIV‐1) infection establishment, progression and latency. Among them, miR‐29a seems to be of particular interest. The aim of this study was to investigate the association between miR‐29a expression and immunologic and virologic markers of HIV infection progression in long‐term antiretroviral‐treated individuals. In a homogenous group of 165 young adults, with chronic HIV infection, parenterally acquired during childhood, the expression level of miR‐29a was found to be inversely correlated with HIV viral load and the degree of immunosuppression, expressed by both CD4 cell count and the CD4/CD8 ratio. There was a significant difference in miR‐29a expression according to the patient's response to treatment, with the lowest levels expressed by patients with treatment failure, defined as detectable viremia and CD4 < 350 cells/mm3. No significant correlation was found between miRNA level and the nadir CD4 count or zenith HIV viral load. This study establishes the association between miR‐29a expression and markers of HIV infection in long‐term survivors, treatment‐experienced patients, suggesting its potential use as an indicator for the on‐treatment disease evolution. J. Med. Virol. 88:2132–2137, 2016. © 2016 Wiley Periodicals, Inc.</description><subject>Adult</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>antiretroviral treatment</subject><subject>Biomarkers - blood</subject><subject>CD4 Lymphocyte Count</subject><subject>CD4-CD8 Ratio</subject><subject>CD4/CD8</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Gene expression</subject><subject>Genetic markers</subject><subject>HIV</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - genetics</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - physiopathology</subject><subject>HIV-1 - genetics</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Lentivirus</subject><subject>Male</subject><subject>microRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - blood</subject><subject>MicroRNAs - genetics</subject><subject>miR-29a</subject><subject>Retroviridae</subject><subject>RNA, Viral - blood</subject><subject>Treatment Failure</subject><subject>Treatment Outcome</subject><subject>Viral Load</subject><subject>Virology</subject><subject>Young Adult</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV1rFDEYhYModlu98A9IwBt7MW2SmXzdCFK0rdYKflTxJsTMO23WmcmaZLbtvzfbbRcVBK_yQp735JwchJ5QskcJYfvzYbnHGq7EPTSjRItKE0nvoxmhjaiEoHwLbac0J4QozdhDtMUkq5nQ9QzB4D9UTFtsUwrO2wwJX_p8gZc-hsoPwzSGPpx7Z3s82PgDYsKhw0fHZ9iPHbjsw1gmnCPYPMCYMVwtIHoYHbR4YXOZcnqEHnS2T_D49txBn1-_-nRwVJ28Pzw-eHlSOa6KVUVbKmuqnXWKN0CspSUWd42lTV2rrpOKt9IqxyxpKJOdbIRrlW20IkyWTDvoxVp3MX0foHXl7Wh7s4i-eL82wXrz583oL8x5WBoupNK1LALPbwVi-DlBymbwyUHf2xHClAxVTCrFuCT_gwqhNGcrW8_-QudhimP5iRXFhdD6htpdUy6GlCJ0G9-UmFXPpvRsbnou7NPfg27Iu2ILsL8GLn0P1_9WMm_end1JVusNnzJcbTZK50bIWnLz5fTQ8Lff6o9fT4UR9S_p3MEp</recordid><startdate>201612</startdate><enddate>201612</enddate><creator>Rosca, Adelina</creator><creator>Anton, Gabriela</creator><creator>Botezatu, Anca</creator><creator>Temereanca, Aura</creator><creator>Ene, Luminita</creator><creator>Achim, Cristian</creator><creator>Ruta, Simona</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7T5</scope><scope>5PM</scope></search><sort><creationdate>201612</creationdate><title>miR-29a associates with viro-immunological markers of HIV infection in treatment experienced patients</title><author>Rosca, Adelina ; Anton, Gabriela ; Botezatu, Anca ; Temereanca, Aura ; Ene, Luminita ; Achim, Cristian ; Ruta, Simona</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5846-81d17319cac854e0aa12455c4a14338ff785d7a8c2a04127f746cd8a498027723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Antiretroviral Therapy, Highly Active</topic><topic>antiretroviral treatment</topic><topic>Biomarkers - blood</topic><topic>CD4 Lymphocyte Count</topic><topic>CD4-CD8 Ratio</topic><topic>CD4/CD8</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Gene expression</topic><topic>Genetic markers</topic><topic>HIV</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - genetics</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - physiopathology</topic><topic>HIV-1 - genetics</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Lentivirus</topic><topic>Male</topic><topic>microRNA</topic><topic>MicroRNAs</topic><topic>MicroRNAs - blood</topic><topic>MicroRNAs - genetics</topic><topic>miR-29a</topic><topic>Retroviridae</topic><topic>RNA, Viral - blood</topic><topic>Treatment Failure</topic><topic>Treatment Outcome</topic><topic>Viral Load</topic><topic>Virology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosca, Adelina</creatorcontrib><creatorcontrib>Anton, Gabriela</creatorcontrib><creatorcontrib>Botezatu, Anca</creatorcontrib><creatorcontrib>Temereanca, Aura</creatorcontrib><creatorcontrib>Ene, Luminita</creatorcontrib><creatorcontrib>Achim, Cristian</creatorcontrib><creatorcontrib>Ruta, Simona</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosca, Adelina</au><au>Anton, Gabriela</au><au>Botezatu, Anca</au><au>Temereanca, Aura</au><au>Ene, Luminita</au><au>Achim, Cristian</au><au>Ruta, Simona</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>miR-29a associates with viro-immunological markers of HIV infection in treatment experienced patients</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J. Med. Virol</addtitle><date>2016-12</date><risdate>2016</risdate><volume>88</volume><issue>12</issue><spage>2132</spage><epage>2137</epage><pages>2132-2137</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><abstract>MicroRNAs (miRNAs) are small, non‐coding RNA species essential for the post‐translational regulation of gene expression. Several miRNA have been proposed to contribute to Human immunodeficiency virus‐1 (HIV‐1) infection establishment, progression and latency. Among them, miR‐29a seems to be of particular interest. The aim of this study was to investigate the association between miR‐29a expression and immunologic and virologic markers of HIV infection progression in long‐term antiretroviral‐treated individuals. In a homogenous group of 165 young adults, with chronic HIV infection, parenterally acquired during childhood, the expression level of miR‐29a was found to be inversely correlated with HIV viral load and the degree of immunosuppression, expressed by both CD4 cell count and the CD4/CD8 ratio. There was a significant difference in miR‐29a expression according to the patient's response to treatment, with the lowest levels expressed by patients with treatment failure, defined as detectable viremia and CD4 < 350 cells/mm3. No significant correlation was found between miRNA level and the nadir CD4 count or zenith HIV viral load. This study establishes the association between miR‐29a expression and markers of HIV infection in long‐term survivors, treatment‐experienced patients, suggesting its potential use as an indicator for the on‐treatment disease evolution. J. Med. Virol. 88:2132–2137, 2016. © 2016 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>27232693</pmid><doi>10.1002/jmv.24586</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Antiretroviral Therapy, Highly Active antiretroviral treatment Biomarkers - blood CD4 Lymphocyte Count CD4-CD8 Ratio CD4/CD8 Disease Progression Female Gene expression Genetic markers HIV HIV Infections - drug therapy HIV Infections - genetics HIV Infections - immunology HIV Infections - physiopathology HIV-1 - genetics Human immunodeficiency virus Humans Lentivirus Male microRNA MicroRNAs MicroRNAs - blood MicroRNAs - genetics miR-29a Retroviridae RNA, Viral - blood Treatment Failure Treatment Outcome Viral Load Virology Young Adult |
| title | miR-29a associates with viro-immunological markers of HIV infection in treatment experienced patients |
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