Use of serological surveys to generate key insights into the changing global landscape of infectious disease

The proportion of individuals protected against a specific pathogen determines the timing and scale of outbreaks, and the pace of evolution for infections that can evade prevailing humoral immunity. Serological surveys provide the most direct measurement to define the immunity landscape for many inf...

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Veröffentlicht in:The Lancet (British edition) 2016-08, Vol.388 (10045), p.728-730
Hauptverfasser: Metcalf, C Jessica E, Dr, Farrar, Jeremy, MD, Cutts, Felicity T, Prof, Basta, Nicole E, PhD, Graham, Andrea L, PhD, Lessler, Justin, PhD, Ferguson, Neil M, Prof, Burke, Donald S, Prof, Grenfell, Bryan T, Prof
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container_title The Lancet (British edition)
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creator Metcalf, C Jessica E, Dr
Farrar, Jeremy, MD
Cutts, Felicity T, Prof
Basta, Nicole E, PhD
Graham, Andrea L, PhD
Lessler, Justin, PhD
Ferguson, Neil M, Prof
Burke, Donald S, Prof
Grenfell, Bryan T, Prof
description The proportion of individuals protected against a specific pathogen determines the timing and scale of outbreaks, and the pace of evolution for infections that can evade prevailing humoral immunity. Serological surveys provide the most direct measurement to define the immunity landscape for many infectious diseases, yet this methodology remains underexploited. To address this gap, we propose a World Serology Bank and associated major methodological developments in serological testing, study design, and quantitative analysis, which could drive a step change in our understanding and optimum control of infectious diseases.
doi_str_mv 10.1016/S0140-6736(16)30164-7
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subjects Antibodies - blood
Blood
Communicable Diseases - blood
Communicable Diseases - immunology
Diagnostic tests
Global Health
Humans
Immunoglobulins
Infectious diseases
Internal Medicine
Medical research
Public health
Serologic Tests
Specimen Handling
title Use of serological surveys to generate key insights into the changing global landscape of infectious disease
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