Use of serological surveys to generate key insights into the changing global landscape of infectious disease
The proportion of individuals protected against a specific pathogen determines the timing and scale of outbreaks, and the pace of evolution for infections that can evade prevailing humoral immunity. Serological surveys provide the most direct measurement to define the immunity landscape for many inf...
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Veröffentlicht in: | The Lancet (British edition) 2016-08, Vol.388 (10045), p.728-730 |
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creator | Metcalf, C Jessica E, Dr Farrar, Jeremy, MD Cutts, Felicity T, Prof Basta, Nicole E, PhD Graham, Andrea L, PhD Lessler, Justin, PhD Ferguson, Neil M, Prof Burke, Donald S, Prof Grenfell, Bryan T, Prof |
description | The proportion of individuals protected against a specific pathogen determines the timing and scale of outbreaks, and the pace of evolution for infections that can evade prevailing humoral immunity. Serological surveys provide the most direct measurement to define the immunity landscape for many infectious diseases, yet this methodology remains underexploited. To address this gap, we propose a World Serology Bank and associated major methodological developments in serological testing, study design, and quantitative analysis, which could drive a step change in our understanding and optimum control of infectious diseases. |
doi_str_mv | 10.1016/S0140-6736(16)30164-7 |
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To address this gap, we propose a World Serology Bank and associated major methodological developments in serological testing, study design, and quantitative analysis, which could drive a step change in our understanding and optimum control of infectious diseases.</description><subject>Antibodies - blood</subject><subject>Blood</subject><subject>Communicable Diseases - blood</subject><subject>Communicable Diseases - immunology</subject><subject>Diagnostic tests</subject><subject>Global Health</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Infectious diseases</subject><subject>Internal Medicine</subject><subject>Medical research</subject><subject>Public health</subject><subject>Serologic Tests</subject><subject>Specimen 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subjects | Antibodies - blood Blood Communicable Diseases - blood Communicable Diseases - immunology Diagnostic tests Global Health Humans Immunoglobulins Infectious diseases Internal Medicine Medical research Public health Serologic Tests Specimen Handling |
title | Use of serological surveys to generate key insights into the changing global landscape of infectious disease |
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