Tolerogenic dendritic cells are efficiently generated using minocycline and dexamethasone

Tolerogenic dendritic cells (tDCs) represent a promising tool for cellular therapy against autoimmune diseases, allergies, and transplantation rejection. Numerous pharmacological agents are known to induce tDC generation. Minocycline, which has long been used as a broad-spectrum antibiotic, was rece...

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Veröffentlicht in:	Scientific reports 2017-11, Vol.7 (1), p.15087-10, Article 15087
Hauptverfasser:	Lee, Jae-Hee, Park, Chan-Su, Jang, Sundong, Kim, Ji-Wan, Kim, Sang-Hyeon, Song, Sukgil, Kim, Kyungjae, Lee, Chong-Kil
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/21 13/31 631/250/21/1566 64 64/60 692/699/249/1313/1666 Allergies Animal models Animals Anti-Bacterial Agents - pharmacology Anti-Inflammatory Agents - pharmacology Antibiotics Autoimmune diseases Autoimmune Diseases - immunology Autoimmune Diseases - therapy Bone Marrow Cells - drug effects Cell Differentiation - drug effects Cells, Cultured Colony-stimulating factor Dendritic cells Dendritic Cells - drug effects Dendritic Cells - immunology Dexamethasone Dexamethasone - pharmacology Encephalitis Experimental allergic encephalomyelitis Female Graft rejection Granulocyte colony-stimulating factor Granulocyte-Macrophage Colony-Stimulating Factor Humanities and Social Sciences Immune Tolerance - drug effects Immune Tolerance - immunology Immunotherapy Immunotherapy - methods Interleukin 4 Interleukin-4 - pharmacology Leukocytes (granulocytic) Mice, Inbred BALB C Mice, Inbred C57BL Minocycline Minocycline - pharmacology multidisciplinary Oligodendrocyte-myelin glycoprotein Rapamycin Science Science (multidisciplinary) Steroids Transplantation Vitamin D3
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