Ozone oil promotes wound healing by increasing the migration of fibroblasts via PI3K/Akt/mTOR signaling pathway

Skin injury affects millions of people via the uncontrolled inflammation and infection. Many cellular components including fibroblasts and signaling pathways such as transforming growth factor-β (TGF-β) were activated to facilitate the wound healing to repair injured tissues. C57BL/6 female mice wer...

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Veröffentlicht in:	Bioscience reports 2017-12, Vol.37 (6)
Hauptverfasser:	Xiao, Weirong, Tang, Hua, Wu, Meng, Liao, Yangying, Li, Ke, Li, Lan, Xu, Xiaopeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - genetics Actins - metabolism Animals Cadherins - genetics Cadherins - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Cell Movement - drug effects Collagen Type I - genetics Collagen Type I - metabolism Epithelial-Mesenchymal Transition - drug effects Female Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - pathology Fibronectins - genetics Fibronectins - metabolism Gene Expression Regulation Humans Mice Mice, Inbred C57BL Oils - pharmacology Ozone - pharmacology Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Signal Transduction Skin - drug effects Skin - injuries Skin - metabolism Surgical Wound - drug therapy Surgical Wound - genetics Surgical Wound - metabolism Surgical Wound - pathology TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism Vimentin - genetics Vimentin - metabolism Wound Healing - drug effects Wound Healing - physiology
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