In silico evidence for sequence-dependent nucleosome sliding

Nucleosomes represent the basic building block of chromatin and provide an important mechanism by which cellular processes are controlled. The locations of nucleosomes across the genome are not random but instead depend on both the underlying DNA sequence and the dynamic action of other proteins wit...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2017-10, Vol.114 (44), p.E9197-E9205
Hauptverfasser:	Lequieu, Joshua, Schwartz, David C., de Pablo, Juan J.
Format:	Artikel
Sprache:	eng
Schlagworte:	advanced sampling techniques BASIC BIOLOGICAL SCIENCES Chromatin Chromatin - genetics Chromatin Assembly and Disassembly - genetics chromatin dynamics Computer Simulation Deoxyribonucleic acid DNA DNA - genetics Free energy Gene Silencing - physiology Genome - genetics Genomes Histone H4 Histones - genetics Models, Molecular molecular simulation Nuclei (cytology) Nucleosomes Nucleosomes - genetics Nucleotide sequence nudeosome repositioning Physical Sciences PNAS Plus Proteins
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