Associations between genetic and epigenetic variations in cytokine genes and mild persistent breast pain in women following breast cancer surgery

•IL6, CXCL8, and TNF are associated with mild persistent breast pain.•CpG methylation in the TNF promoter may contribute to mild persistent breast pain.•These genetic and epigenetic variations may help to identify high risk patients. Persistent pain following breast cancer surgery is a significant p...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2017-11, Vol.99, p.203-213
Hauptverfasser:	Stephens, Kimberly E., Levine, Jon D., Aouizerat, Bradley E., Paul, Steven M., Abrams, Gary, Conley, Yvette P., Miaskowski, Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Breast Neoplasms - surgery C-X-C motif chemokine ligand 8 Cytokine genes Demography DNA methylation DNA Methylation - genetics Epigenesis, Genetic Epigenetics Female Genetic Association Studies Humans Interleukin 6 Interleukin-6 - genetics Interleukin-8 - genetics Logistic Models Mastodynia - etiology Mastodynia - genetics Middle Aged Persistent pain Polymorphism, Single Nucleotide - genetics Post-mastectomy pain Post-surgical pain Promoter Regions, Genetic Tumor necrosis factor Tumor Necrosis Factor-alpha - genetics
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