Differential regulation of mRNAs and lncRNAs related to lipid metabolism in two pig breeds
Long non-coding RNAs (lncRNAs) can regulate lipid metabolism and adipogenesis. However, there is little research on the role of lncRNAs in fat deposition in pig. In this study, RNA-seq technology was used to analyze the gene expression profiles of subcutaneous adipose tissue in Laiwu (LW) and Large...
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Veröffentlicht in: | Oncotarget 2017-10, Vol.8 (50), p.87539-87553 |
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description | Long non-coding RNAs (lncRNAs) can regulate lipid metabolism and adipogenesis. However, there is little research on the role of lncRNAs in fat deposition in pig. In this study, RNA-seq technology was used to analyze the gene expression profiles of subcutaneous adipose tissue in Laiwu (LW) and Large White (LY) pigs. Then, key lncRNAs and genes associated with lipid metabolism and adipogenic differentiation were identified. Fifty four lncRNAs and 482 known mRNAs were differentially expressed in the two pig breeds. GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analyses revealed that differentially expressed genes and the target genes of differentially expressed lncRNAs were significantly enriched in PPAR signaling pathway and biological processes including fat cell differentiation and fatty acid metabolism. Key lncRNAs might regulate adipogenic differentiation and fatty acid metabolism by regulating genes involved in above signaling pathway and biological processes. Specifically,
,
,
,
and
might target
,
,
,
and
, respectively, and then play critical regulatory role. These results are useful for understanding fat deposition in pig, breeding livestock with high quality meat, and preventing and treating lipid metabolic disease. |
doi_str_mv | 10.18632/oncotarget.20978 |
format | Article |
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,
,
,
and
might target
,
,
,
and
, respectively, and then play critical regulatory role. These results are useful for understanding fat deposition in pig, breeding livestock with high quality meat, and preventing and treating lipid metabolic disease.</description><identifier>ISSN: 1949-2553</identifier><identifier>EISSN: 1949-2553</identifier><identifier>DOI: 10.18632/oncotarget.20978</identifier><identifier>PMID: 29152100</identifier><language>eng</language><publisher>United States: Impact Journals LLC</publisher><subject>Research Paper</subject><ispartof>Oncotarget, 2017-10, Vol.8 (50), p.87539-87553</ispartof><rights>Copyright: © 2017 Huang et al. 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-802f0485be29cd01ed82cae473d04efa99a6c369e32cf00533feda033e4f23f63</citedby><cites>FETCH-LOGICAL-c356t-802f0485be29cd01ed82cae473d04efa99a6c369e32cf00533feda033e4f23f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675652/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675652/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29152100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Wanlong</creatorcontrib><creatorcontrib>Zhang, Xiuxiu</creatorcontrib><creatorcontrib>Li, Ai</creatorcontrib><creatorcontrib>Xie, Lingli</creatorcontrib><creatorcontrib>Miao, Xiangyang</creatorcontrib><title>Differential regulation of mRNAs and lncRNAs related to lipid metabolism in two pig breeds</title><title>Oncotarget</title><addtitle>Oncotarget</addtitle><description>Long non-coding RNAs (lncRNAs) can regulate lipid metabolism and adipogenesis. However, there is little research on the role of lncRNAs in fat deposition in pig. In this study, RNA-seq technology was used to analyze the gene expression profiles of subcutaneous adipose tissue in Laiwu (LW) and Large White (LY) pigs. Then, key lncRNAs and genes associated with lipid metabolism and adipogenic differentiation were identified. Fifty four lncRNAs and 482 known mRNAs were differentially expressed in the two pig breeds. GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analyses revealed that differentially expressed genes and the target genes of differentially expressed lncRNAs were significantly enriched in PPAR signaling pathway and biological processes including fat cell differentiation and fatty acid metabolism. Key lncRNAs might regulate adipogenic differentiation and fatty acid metabolism by regulating genes involved in above signaling pathway and biological processes. Specifically,
,
,
,
and
might target
,
,
,
and
, respectively, and then play critical regulatory role. These results are useful for understanding fat deposition in pig, breeding livestock with high quality meat, and preventing and treating lipid metabolic disease.</description><subject>Research Paper</subject><issn>1949-2553</issn><issn>1949-2553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpVUU1PWzEQtCpQQYEf0EvlYy8J_s7zpVIEtCBFrYTaSy-WY6-Dkd9zsB0q_j1PCaVhL7vSzM7uaBD6RMmMdoqzizy43GxZQ5sxoufdB3RKtdBTJiU_OphP0HmtD2QsKeYd0x_RCdNUMkrIKfpzFUOAAkOLNuEC622yLeYB54D7ux-Liu3gcRrcbi4wouBxyzjFTfS4h2ZXOcXa4zjg9jfjTVzjVQHw9QwdB5sqnL_2Cfr97frX5c10-fP77eViOXVcqjbtCAtEdHIFTDtPKPiOOQtizj0REKzWVjmuNHDmwuiB8wDeEs5BBMaD4hP0da-72a568G70UmwymxJ7W55NttG8R4Z4b9b5yUg1l0qyUeDLq0DJj1uozfSxOkjJDpC31VCtlBCMUjFS6Z7qSq61QHg7Q4nZxWL-x2J2sYw7nw__e9v4FwJ_AYQmjSw</recordid><startdate>20171020</startdate><enddate>20171020</enddate><creator>Huang, Wanlong</creator><creator>Zhang, Xiuxiu</creator><creator>Li, Ai</creator><creator>Xie, Lingli</creator><creator>Miao, Xiangyang</creator><general>Impact Journals LLC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20171020</creationdate><title>Differential regulation of mRNAs and lncRNAs related to lipid metabolism in two pig breeds</title><author>Huang, Wanlong ; Zhang, Xiuxiu ; Li, Ai ; Xie, Lingli ; Miao, Xiangyang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-802f0485be29cd01ed82cae473d04efa99a6c369e32cf00533feda033e4f23f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Research Paper</topic><toplevel>online_resources</toplevel><creatorcontrib>Huang, Wanlong</creatorcontrib><creatorcontrib>Zhang, Xiuxiu</creatorcontrib><creatorcontrib>Li, Ai</creatorcontrib><creatorcontrib>Xie, Lingli</creatorcontrib><creatorcontrib>Miao, Xiangyang</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncotarget</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Wanlong</au><au>Zhang, Xiuxiu</au><au>Li, Ai</au><au>Xie, Lingli</au><au>Miao, Xiangyang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential regulation of mRNAs and lncRNAs related to lipid metabolism in two pig breeds</atitle><jtitle>Oncotarget</jtitle><addtitle>Oncotarget</addtitle><date>2017-10-20</date><risdate>2017</risdate><volume>8</volume><issue>50</issue><spage>87539</spage><epage>87553</epage><pages>87539-87553</pages><issn>1949-2553</issn><eissn>1949-2553</eissn><abstract>Long non-coding RNAs (lncRNAs) can regulate lipid metabolism and adipogenesis. However, there is little research on the role of lncRNAs in fat deposition in pig. In this study, RNA-seq technology was used to analyze the gene expression profiles of subcutaneous adipose tissue in Laiwu (LW) and Large White (LY) pigs. Then, key lncRNAs and genes associated with lipid metabolism and adipogenic differentiation were identified. Fifty four lncRNAs and 482 known mRNAs were differentially expressed in the two pig breeds. GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analyses revealed that differentially expressed genes and the target genes of differentially expressed lncRNAs were significantly enriched in PPAR signaling pathway and biological processes including fat cell differentiation and fatty acid metabolism. Key lncRNAs might regulate adipogenic differentiation and fatty acid metabolism by regulating genes involved in above signaling pathway and biological processes. Specifically,
,
,
,
and
might target
,
,
,
and
, respectively, and then play critical regulatory role. These results are useful for understanding fat deposition in pig, breeding livestock with high quality meat, and preventing and treating lipid metabolic disease.</abstract><cop>United States</cop><pub>Impact Journals LLC</pub><pmid>29152100</pmid><doi>10.18632/oncotarget.20978</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Research Paper |
title | Differential regulation of mRNAs and lncRNAs related to lipid metabolism in two pig breeds |
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