BLM helicase regulates DNA repair by counteracting RAD51 loading at DNA double-strand break sites

The gene product, BLM, is a RECQ helicase that is involved in DNA replication and repair of DNA double-strand breaks by the homologous recombination (HR) pathway. During HR, BLM has both pro- and anti-recombinogenic activities, either of which may contribute to maintenance of genomic integrity. We f...

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Veröffentlicht in:	The Journal of cell biology 2017-11, Vol.216 (11), p.3521-3534
Hauptverfasser:	Patel, Dharm S, Misenko, Sarah M, Her, Joonyoung, Bunting, Samuel F
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Animals BLM gene BRCA1 protein BRCA1 Protein - genetics BRCA1 Protein - metabolism BRCA2 protein BRCA2 Protein - deficiency BRCA2 Protein - genetics Breast cancer Cell Line, Tumor Cell Survival Cells Deoxyribonucleic acid DNA DNA biosynthesis DNA Breaks, Double-Stranded DNA damage DNA helicase DNA repair DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics Double-strand break repair Genes Genomic Instability Genomics Genotype Homologous recombination Homology Humans Integrity Lymphocytes - enzymology Lymphocytes - pathology Mice, Knockout Mutation Neoplasms - enzymology Neoplasms - genetics Neoplasms - pathology Phenotype Protein Stability Rad51 Recombinase - genetics Rad51 Recombinase - metabolism Recombinase Recombinational DNA Repair RecQ Helicases - deficiency RecQ Helicases - genetics RecQ Helicases - metabolism RecQ protein Repair RNA Interference Transfection Tumor Suppressor p53-Binding Protein 1 - deficiency Tumor Suppressor p53-Binding Protein 1 - genetics Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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