Germ-Cell-Specific Inflammasome Component NLRP14 Negatively Regulates Cytosolic Nucleic Acid Sensing to Promote Fertilization

Cytosolic sensing of nucleic acids initiates tightly regulated programs to limit infection. Oocyte fertilization represents a scenario wherein inappropriate responses to exogenous yet non-pathogen-derived nucleic acids would have negative consequences. We hypothesized that germ cells express negativ...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2017-04, Vol.46 (4), p.621-634
Hauptverfasser:	Abe, Takayuki, Lee, Albert, Sitharam, Ramaswami, Kesner, Jordan, Rabadan, Raul, Shapira, Sagi D.
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Animals Candidates Cercopithecus aethiops Collaboration Cytokines Cytosol - immunology Cytosol - metabolism Data mining Deoxyribonucleic acid Detection DNA DNA/RNA sensing Female Fertilization Fertilization - genetics Fertilization - immunology Gene Expression - immunology Genes Genomics Germ cells Germ Cells - immunology Germ Cells - metabolism Germ-Line Mutation - immunology HEK293 Cells Humans Immunoblotting Infertility, Male - genetics Infertility, Male - immunology inflammasome Inflammasomes Inflammasomes - genetics Inflammasomes - immunology Inflammasomes - metabolism innate immunity Kinases Male Male sterility nucleic acid sensing Nucleic acids Nucleic Acids - immunology Nucleic Acids - metabolism Nucleoside-Triphosphatase - genetics Nucleoside-Triphosphatase - immunology Nucleoside-Triphosphatase - metabolism Protein Binding - immunology Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - immunology Protein-Serine-Threonine Kinases - metabolism Proteins regulation Regulators Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid RIG-I RNA Rodents Signal Transduction - genetics Signal Transduction - immunology Stem cells STING TBK1 Vero Cells
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