An essential role for PNLDC1 in piRNA 3＇ end trimming and male fertility in mice
Dear Editor, PIWI-interacting RNAs （piRNAs） are germ cell-specific small non-coding RNAs that are essential for silenc- ing transposable elements. Substantial efforts in the past decade have led to an understanding of how piRNAs are made. Primary piRNA biogenesis is initiated with transcription of p...
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| Veröffentlicht in: | Cell research 2017-11, Vol.27 (11), p.1392-1396 |
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| creator | Zhang, Yue Guo, Rui Cui, Yiqiang Zhu, Zhiping Zhang, Yingwen Wu, Hao Zheng, Bo Yue, Qiuling Bai, Shun Zeng, Wentao Guo, Xuejiang Zhou, Zuomin Shen, Bin Zheng, Ke Liu, Mingxi Ye, Lan Sha, Jiahao |
| description | Dear Editor, PIWI-interacting RNAs （piRNAs） are germ cell-specific small non-coding RNAs that are essential for silenc- ing transposable elements. Substantial efforts in the past decade have led to an understanding of how piRNAs are made. Primary piRNA biogenesis is initiated with transcription of piRNA precursors, followed by cleavage into piRNA intermediates, and finally, maturation by 3＇ end trimming and 2＇-O-methylation. Secondary piRNA biogenesis occurs through an amplification loop （ping pong pathway）; the piRNA pools generated through pri- mary processing guide MILI protein to cleave the target RNA for piRNA generation in a feed-forward loop that accelerates production of the piRNAs. Papi/Tdrkh has been implicated in processing the 3＇ ends of piRNAs [1, 2], however, |
| doi_str_mv | 10.1038/cr.2017.125 |
| format | Article |
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Substantial efforts in the past decade have led to an understanding of how piRNAs are made. Primary piRNA biogenesis is initiated with transcription of piRNA precursors, followed by cleavage into piRNA intermediates, and finally, maturation by 3＇ end trimming and 2＇-O-methylation. Secondary piRNA biogenesis occurs through an amplification loop （ping pong pathway）; the piRNA pools generated through pri- mary processing guide MILI protein to cleave the target RNA for piRNA generation in a feed-forward loop that accelerates production of the piRNAs. Papi/Tdrkh has been implicated in processing the 3＇ ends of piRNAs [1, 2], however,</description><identifier>ISSN: 1001-0602</identifier><identifier>EISSN: 1748-7838</identifier><identifier>DOI: 10.1038/cr.2017.125</identifier><identifier>PMID: 28994417</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/136/2434/1822 ; 631/443/494 ; 631/45/500 ; 631/80/641/1633 ; Animals ; Biomedical and Life Sciences ; Cell Biology ; Female ; Fertility ; Fertility - genetics ; Letter to the Editor ; Life Sciences ; Male ; Mice ; Mice, Knockout ; Ribonucleases - genetics ; Ribonucleases - physiology ; RNA, Small Interfering - metabolism ; Spermatogenesis - genetics ; Testis - metabolism</subject><ispartof>Cell research, 2017-11, Vol.27 (11), p.1392-1396</ispartof><rights>Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2017</rights><rights>Copyright Nature Publishing Group Nov 2017</rights><rights>Copyright © 2017 Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2017 Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-4142f736a456de11c086ccab20b1a6080b476853f4bdf94b770bf5212dbfaf4f3</citedby><cites>FETCH-LOGICAL-c539t-4142f736a456de11c086ccab20b1a6080b476853f4bdf94b770bf5212dbfaf4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85240X/85240X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674159/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674159/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28994417$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yue</creatorcontrib><creatorcontrib>Guo, Rui</creatorcontrib><creatorcontrib>Cui, Yiqiang</creatorcontrib><creatorcontrib>Zhu, Zhiping</creatorcontrib><creatorcontrib>Zhang, Yingwen</creatorcontrib><creatorcontrib>Wu, Hao</creatorcontrib><creatorcontrib>Zheng, Bo</creatorcontrib><creatorcontrib>Yue, Qiuling</creatorcontrib><creatorcontrib>Bai, Shun</creatorcontrib><creatorcontrib>Zeng, Wentao</creatorcontrib><creatorcontrib>Guo, Xuejiang</creatorcontrib><creatorcontrib>Zhou, Zuomin</creatorcontrib><creatorcontrib>Shen, Bin</creatorcontrib><creatorcontrib>Zheng, Ke</creatorcontrib><creatorcontrib>Liu, Mingxi</creatorcontrib><creatorcontrib>Ye, Lan</creatorcontrib><creatorcontrib>Sha, Jiahao</creatorcontrib><title>An essential role for PNLDC1 in piRNA 3＇ end trimming and male fertility in mice</title><title>Cell research</title><addtitle>Cell Res</addtitle><addtitle>Cell Research</addtitle><description>Dear Editor, PIWI-interacting RNAs （piRNAs） are germ cell-specific small non-coding RNAs that are essential for silenc- ing transposable elements. Substantial efforts in the past decade have led to an understanding of how piRNAs are made. Primary piRNA biogenesis is initiated with transcription of piRNA precursors, followed by cleavage into piRNA intermediates, and finally, maturation by 3＇ end trimming and 2＇-O-methylation. Secondary piRNA biogenesis occurs through an amplification loop （ping pong pathway）; the piRNA pools generated through pri- mary processing guide MILI protein to cleave the target RNA for piRNA generation in a feed-forward loop that accelerates production of the piRNAs. Papi/Tdrkh has been implicated in processing the 3＇ ends of piRNAs [1, 2], however,</description><subject>631/136/2434/1822</subject><subject>631/443/494</subject><subject>631/45/500</subject><subject>631/80/641/1633</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Female</subject><subject>Fertility</subject><subject>Fertility - genetics</subject><subject>Letter to the Editor</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Ribonucleases - genetics</subject><subject>Ribonucleases - physiology</subject><subject>RNA, Small Interfering - metabolism</subject><subject>Spermatogenesis - genetics</subject><subject>Testis - metabolism</subject><issn>1001-0602</issn><issn>1748-7838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkd2KFDEQhRtR3HX1ynsJeiNoj6n852ZhGH9hWGXR65DOJLNZutOzSY-wT-BL-U6-ghlmHFbxKhXqq1OnOE3zFPAMMFVvXJ4RDHIGhN9rTkEy1UpF1f1aYwwtFpicNI9KucaYcMbhYXNClNaMgTxtLucJ-VJ8mqLtUR57j8KY0ZeL5dsFoJjQJl5ezBH99fMH8mmFphyHIaY1svUz2B3u8xT7ON3u6CE6_7h5EGxf_JPDe9Z8e__u6-Jju_z84dNivmwdp3pqGTASJBWWcbHyAA4r4ZztCO7ACqxwx6RQnAbWrYJmnZS4C5wAWXXBBhboWXO-191su8GvXL0h295sqkObb81oo_m7k-KVWY_fDReSAddV4OVBII83W18mM8TifN_b5MdtMaCZFpozChV98Q96PW5zqudVimvQQmpWqVd7yuWxlOzD0Qxgs8vKuGx2WZmaVaWf3fV_ZP-EU4HXe6DUVlr7fGfpf_WeH7ZfjWl9UyeOkkJSqZQgmv4Gad-opw</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>Zhang, Yue</creator><creator>Guo, Rui</creator><creator>Cui, Yiqiang</creator><creator>Zhu, Zhiping</creator><creator>Zhang, Yingwen</creator><creator>Wu, Hao</creator><creator>Zheng, Bo</creator><creator>Yue, Qiuling</creator><creator>Bai, Shun</creator><creator>Zeng, Wentao</creator><creator>Guo, Xuejiang</creator><creator>Zhou, Zuomin</creator><creator>Shen, Bin</creator><creator>Zheng, Ke</creator><creator>Liu, Mingxi</creator><creator>Ye, Lan</creator><creator>Sha, Jiahao</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W94</scope><scope>WU4</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20171101</creationdate><title>An essential role for PNLDC1 in piRNA 3＇ end trimming and male fertility in mice</title><author>Zhang, Yue ; Guo, Rui ; Cui, Yiqiang ; Zhu, Zhiping ; Zhang, Yingwen ; Wu, Hao ; Zheng, Bo ; Yue, Qiuling ; Bai, Shun ; Zeng, Wentao ; Guo, Xuejiang ; Zhou, Zuomin ; Shen, Bin ; Zheng, Ke ; Liu, Mingxi ; Ye, Lan ; Sha, Jiahao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-4142f736a456de11c086ccab20b1a6080b476853f4bdf94b770bf5212dbfaf4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>631/136/2434/1822</topic><topic>631/443/494</topic><topic>631/45/500</topic><topic>631/80/641/1633</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Cell Biology</topic><topic>Female</topic><topic>Fertility</topic><topic>Fertility - genetics</topic><topic>Letter to the Editor</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Ribonucleases - genetics</topic><topic>Ribonucleases - physiology</topic><topic>RNA, Small Interfering - metabolism</topic><topic>Spermatogenesis - genetics</topic><topic>Testis - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yue</creatorcontrib><creatorcontrib>Guo, Rui</creatorcontrib><creatorcontrib>Cui, Yiqiang</creatorcontrib><creatorcontrib>Zhu, Zhiping</creatorcontrib><creatorcontrib>Zhang, Yingwen</creatorcontrib><creatorcontrib>Wu, Hao</creatorcontrib><creatorcontrib>Zheng, Bo</creatorcontrib><creatorcontrib>Yue, Qiuling</creatorcontrib><creatorcontrib>Bai, Shun</creatorcontrib><creatorcontrib>Zeng, Wentao</creatorcontrib><creatorcontrib>Guo, Xuejiang</creatorcontrib><creatorcontrib>Zhou, Zuomin</creatorcontrib><creatorcontrib>Shen, Bin</creatorcontrib><creatorcontrib>Zheng, Ke</creatorcontrib><creatorcontrib>Liu, Mingxi</creatorcontrib><creatorcontrib>Ye, Lan</creatorcontrib><creatorcontrib>Sha, Jiahao</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-自然科学</collection><collection>中文科技期刊数据库-自然科学-生物科学</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yue</au><au>Guo, Rui</au><au>Cui, Yiqiang</au><au>Zhu, Zhiping</au><au>Zhang, Yingwen</au><au>Wu, Hao</au><au>Zheng, Bo</au><au>Yue, Qiuling</au><au>Bai, Shun</au><au>Zeng, Wentao</au><au>Guo, Xuejiang</au><au>Zhou, Zuomin</au><au>Shen, Bin</au><au>Zheng, Ke</au><au>Liu, Mingxi</au><au>Ye, Lan</au><au>Sha, Jiahao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An essential role for PNLDC1 in piRNA 3＇ end trimming and male fertility in mice</atitle><jtitle>Cell research</jtitle><stitle>Cell Res</stitle><addtitle>Cell Research</addtitle><date>2017-11-01</date><risdate>2017</risdate><volume>27</volume><issue>11</issue><spage>1392</spage><epage>1396</epage><pages>1392-1396</pages><issn>1001-0602</issn><eissn>1748-7838</eissn><abstract>Dear Editor, PIWI-interacting RNAs （piRNAs） are germ cell-specific small non-coding RNAs that are essential for silenc- ing transposable elements. Substantial efforts in the past decade have led to an understanding of how piRNAs are made. Primary piRNA biogenesis is initiated with transcription of piRNA precursors, followed by cleavage into piRNA intermediates, and finally, maturation by 3＇ end trimming and 2＇-O-methylation. Secondary piRNA biogenesis occurs through an amplification loop （ping pong pathway）; the piRNA pools generated through pri- mary processing guide MILI protein to cleave the target RNA for piRNA generation in a feed-forward loop that accelerates production of the piRNAs. Papi/Tdrkh has been implicated in processing the 3＇ ends of piRNAs [1, 2], however,</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28994417</pmid><doi>10.1038/cr.2017.125</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/136/2434/1822 631/443/494 631/45/500 631/80/641/1633 Animals Biomedical and Life Sciences Cell Biology Female Fertility Fertility - genetics Letter to the Editor Life Sciences Male Mice Mice, Knockout Ribonucleases - genetics Ribonucleases - physiology RNA, Small Interfering - metabolism Spermatogenesis - genetics Testis - metabolism |
| title | An essential role for PNLDC1 in piRNA 3＇ end trimming and male fertility in mice |
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