Small infrarenal aortic diameter associated with lower-extremity peripheral artery disease in Chinese hypertensive adults
Several studies suggest that infrarenal aortic diameter is associated with lower-extremity peripheral artery disease (LE-PAD). However, data regarding the associations between infrarenal aortic diameter and LE-PAD are limited, especially in large sample populations and Asian or Chinese populations....
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| creator | Liu, Jie Jia, Xin Jia, Senhao Qin, Xianhui Zhang, Tao Liu, Lishun Li, Haibo Rong, Dan Zhou, Ziyi Song, Yuxiang Zuo, Shangwei Duan, Chen Wu, Zhongyin Wei, Ren Ge, Yangyang Wang, Xian Kong, Wei Xu, Xiping Khalil, Raouf A. Huo, Yong Guo, Wei |
| description | Several studies suggest that infrarenal aortic diameter is associated with lower-extremity peripheral artery disease (LE-PAD). However, data regarding the associations between infrarenal aortic diameter and LE-PAD are limited, especially in large sample populations and Asian or Chinese populations. Our analysis included 17279 Chinese hypertensive adults comprising 6590 men and 10689 women with a mean age of 64.74 ± 7.41 years. Participants were selected from 22693 candidates from two large population-based cohort-studies. The primary noninvasive test for diagnosis of LE-PAD is the ankle–brachial index (ABI) at rest and typically an ABI ≤ 0.90 is used to define LE-PAD. The prevalence of LE-PAD was found to significantly decrease as the aortic diameter increased according to the tertile of the aortic diameter. LE-PAD was significantly more prevalent in the lowest tertile (OR = 1.58, 95% CI = 1.29–1.94, p 0.05). In conclusion, Small aortic diameter (as opposed to large aortic diameter) is significantly associated with LE-PAD in Chinese hypertensive adults. |
| doi_str_mv | 10.1038/s41598-017-12587-x |
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However, data regarding the associations between infrarenal aortic diameter and LE-PAD are limited, especially in large sample populations and Asian or Chinese populations. Our analysis included 17279 Chinese hypertensive adults comprising 6590 men and 10689 women with a mean age of 64.74 ± 7.41 years. Participants were selected from 22693 candidates from two large population-based cohort-studies. The primary noninvasive test for diagnosis of LE-PAD is the ankle–brachial index (ABI) at rest and typically an ABI ≤ 0.90 is used to define LE-PAD. The prevalence of LE-PAD was found to significantly decrease as the aortic diameter increased according to the tertile of the aortic diameter. LE-PAD was significantly more prevalent in the lowest tertile (OR = 1.58, 95% CI = 1.29–1.94, p < 0.001) and similarly prevalent in the highest tertile (OR = 0.92, 95% CI = 0.73–1.16, p = 0.49) when compared with the median tertile. No significant interactions between the aortic diameter and any of the stratified variables were found (all p > 0.05). In conclusion, Small aortic diameter (as opposed to large aortic diameter) is significantly associated with LE-PAD in Chinese hypertensive adults.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-017-12587-x</identifier><identifier>PMID: 29109408</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/174 ; 692/499 ; 692/699/75/593/1920 ; 692/699/75/593/2100 ; Aged ; Aneurysms ; Ankle ; Ankle Brachial Index ; Aorta ; Aorta, Abdominal - pathology ; China - epidemiology ; Female ; Humanities and Social Sciences ; Humans ; Hypertension ; Hypertension - etiology ; Hypertension - pathology ; Leg - blood supply ; Logistic Models ; Male ; Middle Aged ; multidisciplinary ; Peripheral Arterial Disease - epidemiology ; Peripheral Arterial Disease - etiology ; Peripheral Arterial Disease - pathology ; Population studies ; Prevalence ; Risk Factors ; Science ; Science (multidisciplinary) ; Vascular diseases</subject><ispartof>Scientific reports, 2017-11, Vol.7 (1), p.14547-8, Article 14547</ispartof><rights>The Author(s) 2017</rights><rights>2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c425t-963121459c37945c346fd21f6a773ada83d90ccda1a0a8a19e6cb64d69b24e723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674057/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674057/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29109408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Jie</creatorcontrib><creatorcontrib>Jia, Xin</creatorcontrib><creatorcontrib>Jia, Senhao</creatorcontrib><creatorcontrib>Qin, Xianhui</creatorcontrib><creatorcontrib>Zhang, Tao</creatorcontrib><creatorcontrib>Liu, Lishun</creatorcontrib><creatorcontrib>Li, Haibo</creatorcontrib><creatorcontrib>Rong, Dan</creatorcontrib><creatorcontrib>Zhou, Ziyi</creatorcontrib><creatorcontrib>Song, Yuxiang</creatorcontrib><creatorcontrib>Zuo, Shangwei</creatorcontrib><creatorcontrib>Duan, Chen</creatorcontrib><creatorcontrib>Wu, Zhongyin</creatorcontrib><creatorcontrib>Wei, Ren</creatorcontrib><creatorcontrib>Ge, Yangyang</creatorcontrib><creatorcontrib>Wang, Xian</creatorcontrib><creatorcontrib>Kong, Wei</creatorcontrib><creatorcontrib>Xu, Xiping</creatorcontrib><creatorcontrib>Khalil, Raouf A.</creatorcontrib><creatorcontrib>Huo, Yong</creatorcontrib><creatorcontrib>Guo, Wei</creatorcontrib><title>Small infrarenal aortic diameter associated with lower-extremity peripheral artery disease in Chinese hypertensive adults</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Several studies suggest that infrarenal aortic diameter is associated with lower-extremity peripheral artery disease (LE-PAD). However, data regarding the associations between infrarenal aortic diameter and LE-PAD are limited, especially in large sample populations and Asian or Chinese populations. Our analysis included 17279 Chinese hypertensive adults comprising 6590 men and 10689 women with a mean age of 64.74 ± 7.41 years. Participants were selected from 22693 candidates from two large population-based cohort-studies. The primary noninvasive test for diagnosis of LE-PAD is the ankle–brachial index (ABI) at rest and typically an ABI ≤ 0.90 is used to define LE-PAD. The prevalence of LE-PAD was found to significantly decrease as the aortic diameter increased according to the tertile of the aortic diameter. LE-PAD was significantly more prevalent in the lowest tertile (OR = 1.58, 95% CI = 1.29–1.94, p < 0.001) and similarly prevalent in the highest tertile (OR = 0.92, 95% CI = 0.73–1.16, p = 0.49) when compared with the median tertile. No significant interactions between the aortic diameter and any of the stratified variables were found (all p > 0.05). In conclusion, Small aortic diameter (as opposed to large aortic diameter) is significantly associated with LE-PAD in Chinese hypertensive adults.</description><subject>692/308/174</subject><subject>692/499</subject><subject>692/699/75/593/1920</subject><subject>692/699/75/593/2100</subject><subject>Aged</subject><subject>Aneurysms</subject><subject>Ankle</subject><subject>Ankle Brachial Index</subject><subject>Aorta</subject><subject>Aorta, Abdominal - pathology</subject><subject>China - epidemiology</subject><subject>Female</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - etiology</subject><subject>Hypertension - pathology</subject><subject>Leg - blood supply</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Peripheral Arterial Disease - epidemiology</subject><subject>Peripheral Arterial Disease - etiology</subject><subject>Peripheral Arterial Disease - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Jie</au><au>Jia, Xin</au><au>Jia, Senhao</au><au>Qin, Xianhui</au><au>Zhang, Tao</au><au>Liu, Lishun</au><au>Li, Haibo</au><au>Rong, Dan</au><au>Zhou, Ziyi</au><au>Song, Yuxiang</au><au>Zuo, Shangwei</au><au>Duan, Chen</au><au>Wu, Zhongyin</au><au>Wei, Ren</au><au>Ge, Yangyang</au><au>Wang, Xian</au><au>Kong, Wei</au><au>Xu, Xiping</au><au>Khalil, Raouf A.</au><au>Huo, Yong</au><au>Guo, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Small infrarenal aortic diameter associated with lower-extremity peripheral artery disease in Chinese hypertensive adults</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-11-06</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>14547</spage><epage>8</epage><pages>14547-8</pages><artnum>14547</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Several studies suggest that infrarenal aortic diameter is associated with lower-extremity peripheral artery disease (LE-PAD). However, data regarding the associations between infrarenal aortic diameter and LE-PAD are limited, especially in large sample populations and Asian or Chinese populations. Our analysis included 17279 Chinese hypertensive adults comprising 6590 men and 10689 women with a mean age of 64.74 ± 7.41 years. Participants were selected from 22693 candidates from two large population-based cohort-studies. The primary noninvasive test for diagnosis of LE-PAD is the ankle–brachial index (ABI) at rest and typically an ABI ≤ 0.90 is used to define LE-PAD. The prevalence of LE-PAD was found to significantly decrease as the aortic diameter increased according to the tertile of the aortic diameter. LE-PAD was significantly more prevalent in the lowest tertile (OR = 1.58, 95% CI = 1.29–1.94, p < 0.001) and similarly prevalent in the highest tertile (OR = 0.92, 95% CI = 0.73–1.16, p = 0.49) when compared with the median tertile. No significant interactions between the aortic diameter and any of the stratified variables were found (all p > 0.05). In conclusion, Small aortic diameter (as opposed to large aortic diameter) is significantly associated with LE-PAD in Chinese hypertensive adults.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29109408</pmid><doi>10.1038/s41598-017-12587-x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/308/174 692/499 692/699/75/593/1920 692/699/75/593/2100 Aged Aneurysms Ankle Ankle Brachial Index Aorta Aorta, Abdominal - pathology China - epidemiology Female Humanities and Social Sciences Humans Hypertension Hypertension - etiology Hypertension - pathology Leg - blood supply Logistic Models Male Middle Aged multidisciplinary Peripheral Arterial Disease - epidemiology Peripheral Arterial Disease - etiology Peripheral Arterial Disease - pathology Population studies Prevalence Risk Factors Science Science (multidisciplinary) Vascular diseases |
| title | Small infrarenal aortic diameter associated with lower-extremity peripheral artery disease in Chinese hypertensive adults |
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