Transcriptomic profiling in human mesangial cells using patient-derived lupus autoantibodies identified miR-10a as a potential regulator of IL8

Autoantibody-mediated inflammation directed at resident kidney cells mediates lupus nephritis (LN) pathogenesis. This study investigated the role of miRNA in human mesangial cells (HMCs) stimulated with auto anti-dsDNA immunoglobulin (Ig)G antibodies. HMCs were treated with antibodies purified from...

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Veröffentlicht in:	Scientific reports 2017-11, Vol.7 (1), p.14517-18, Article 14517
Hauptverfasser:	Tangtanatakul, Pattarin, Thammasate, Boonyakiat, Jacquet, Alain, Reantragoon, Rangsima, Pisitkun, Trairak, Avihingsanon, Yingyos, Leelahavanichkul, Asada, Hirankarn, Nattiya
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 13/109 13/31 45 631/337/176/2016 692/4023/1670/1613/1614 82/16 Adult Anti-DNA antibodies Apoptosis Autoantibodies Autoantibodies - metabolism Cadavers Cell cycle Cell proliferation Chemokines Female Gene Expression Profiling Gene Expression Regulation Gene regulation Humanities and Social Sciences Humans Immunoglobulin G Immunoglobulin G - metabolism Interleukin 8 Interleukin-6 - metabolism Interleukin-8 - metabolism Kidney transplantation Kidneys Lupus Lupus nephritis Lupus Nephritis - immunology Male Mesangial cells Mesangial Cells - immunology MicroRNAs - metabolism miRNA multidisciplinary Nephritis Next-generation sequencing RNA, Messenger - metabolism Science Science (multidisciplinary) Signal transduction Transcription
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