Effects of ursolic and oleanolic on SK-MEL-2 melanoma cells: In vitro and in vivo assays
Among the triterpenoids, oleanolic acid (OA) and its isomer, ursolic acid (UA) are promising therapeutic candidates, with potential benefits in the management of melanoma. In this study, we aimed to examine the in vitro and in vivo anti-invasive and anti-metastatic activity of OA and UA to determine...
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| Veröffentlicht in: | International journal of oncology 2017-12, Vol.51 (6), p.1651-1660 |
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| creator | Caunii, Angela Oprean, Camelia Cristea, Mirabela Ivan, Alexandra Danciu, Corina Tatu, Calin Paunescu, Virgil Marti, Daniela Tzanakakis, George Spandidos, Demetrios A Tsatsakis, Aristides Susan, Razvan Soica, Codruta Avram, Stefana Dehelean, Cristina |
| description | Among the triterpenoids, oleanolic acid (OA) and its isomer, ursolic acid (UA) are promising therapeutic candidates, with potential benefits in the management of melanoma. In this study, we aimed to examine the in vitro and in vivo anti-invasive and anti-metastatic activity of OA and UA to determine their possible usefulness as chemopreventive or chemotherapeutic agents in melanoma. For the in vitro experiments, the anti-proliferative activity of the triterpenic compounds on SK-MEL-2 melanoma cells was examined. The anti-invasive potential was assessed by testing the effects of the active compound on vascular cell adhesion molecule (VCAM) and intercellular adhesion molecule (ICAM) adhesion to melanoma cells. Normal and tumor angiogenesis were evaluated in vivo by chicken embryo chorioallantoic membrane (CAM) assay. The two test triterpenoid acids, UA and OA, exerted differential effects in vitro and in vivo on the SK-MEL-2 melanoma cells. UA exerted a significant and dose-dependent anti-proliferative effect in vitro, compared to OA. The cytotoxic effects in vitro on the melanoma cells were determined by the examining alterations in the cell cycle phases induced by UA that lead to cell arrest in the S phase. Moreover, UA was found to affect SK-MEL-2 melanoma cell invasiveness by limiting the cell adhesion capacity to ICAM molecules, but not influencing their adhesion to VCAM molecules. On the whole, in this study, by assessing the effects of the two triterpenoids in vivo, our results revealed that OA had a greater potential to impair the invasive capacity and tumor angiogenesis compared with UA. |
| doi_str_mv | 10.3892/ijo.2017.4160 |
| format | Article |
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In this study, we aimed to examine the in vitro and in vivo anti-invasive and anti-metastatic activity of OA and UA to determine their possible usefulness as chemopreventive or chemotherapeutic agents in melanoma. For the in vitro experiments, the anti-proliferative activity of the triterpenic compounds on SK-MEL-2 melanoma cells was examined. The anti-invasive potential was assessed by testing the effects of the active compound on vascular cell adhesion molecule (VCAM) and intercellular adhesion molecule (ICAM) adhesion to melanoma cells. Normal and tumor angiogenesis were evaluated in vivo by chicken embryo chorioallantoic membrane (CAM) assay. The two test triterpenoid acids, UA and OA, exerted differential effects in vitro and in vivo on the SK-MEL-2 melanoma cells. UA exerted a significant and dose-dependent anti-proliferative effect in vitro, compared to OA. The cytotoxic effects in vitro on the melanoma cells were determined by the examining alterations in the cell cycle phases induced by UA that lead to cell arrest in the S phase. Moreover, UA was found to affect SK-MEL-2 melanoma cell invasiveness by limiting the cell adhesion capacity to ICAM molecules, but not influencing their adhesion to VCAM molecules. On the whole, in this study, by assessing the effects of the two triterpenoids in vivo, our results revealed that OA had a greater potential to impair the invasive capacity and tumor angiogenesis compared with UA.</description><identifier>ISSN: 1019-6439</identifier><identifier>EISSN: 1791-2423</identifier><identifier>DOI: 10.3892/ijo.2017.4160</identifier><identifier>PMID: 29039461</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Angiogenesis Inhibitors - pharmacology ; Animals ; anti-angiogenic ; anti-invasive ; Care and treatment ; Cell Adhesion - drug effects ; Cell Cycle - drug effects ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Chick Embryo ; Chorioallantoic Membrane - blood supply ; Chorioallantoic Membrane - drug effects ; Development and progression ; Health aspects ; Humans ; Kinases ; Melanoma ; Melanoma - blood supply ; Melanoma - drug therapy ; Melanoma - pathology ; Mutation ; Neovascularization, Physiologic - drug effects ; oleanolic acid ; Oleanolic Acid - pharmacology ; Skin cancer ; Skin Neoplasms - blood supply ; Skin Neoplasms - drug therapy ; Skin Neoplasms - pathology ; Studies ; Terpenoids ; Triterpenes - pharmacology ; Ursolic Acid</subject><ispartof>International journal of oncology, 2017-12, Vol.51 (6), p.1651-1660</ispartof><rights>Copyright: © Caunii et al.</rights><rights>COPYRIGHT 2017 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2017</rights><rights>Copyright: © Caunii et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c545t-8cb3de9623e129d726c295545132d9e31552171c2d290d2819be7a5c996a0063</citedby><cites>FETCH-LOGICAL-c545t-8cb3de9623e129d726c295545132d9e31552171c2d290d2819be7a5c996a0063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,5556,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29039461$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caunii, Angela</creatorcontrib><creatorcontrib>Oprean, Camelia</creatorcontrib><creatorcontrib>Cristea, Mirabela</creatorcontrib><creatorcontrib>Ivan, Alexandra</creatorcontrib><creatorcontrib>Danciu, Corina</creatorcontrib><creatorcontrib>Tatu, Calin</creatorcontrib><creatorcontrib>Paunescu, Virgil</creatorcontrib><creatorcontrib>Marti, Daniela</creatorcontrib><creatorcontrib>Tzanakakis, George</creatorcontrib><creatorcontrib>Spandidos, Demetrios A</creatorcontrib><creatorcontrib>Tsatsakis, Aristides</creatorcontrib><creatorcontrib>Susan, Razvan</creatorcontrib><creatorcontrib>Soica, Codruta</creatorcontrib><creatorcontrib>Avram, Stefana</creatorcontrib><creatorcontrib>Dehelean, Cristina</creatorcontrib><title>Effects of ursolic and oleanolic on SK-MEL-2 melanoma cells: In vitro and in vivo assays</title><title>International journal of oncology</title><addtitle>Int J Oncol</addtitle><description>Among the triterpenoids, oleanolic acid (OA) and its isomer, ursolic acid (UA) are promising therapeutic candidates, with potential benefits in the management of melanoma. In this study, we aimed to examine the in vitro and in vivo anti-invasive and anti-metastatic activity of OA and UA to determine their possible usefulness as chemopreventive or chemotherapeutic agents in melanoma. For the in vitro experiments, the anti-proliferative activity of the triterpenic compounds on SK-MEL-2 melanoma cells was examined. The anti-invasive potential was assessed by testing the effects of the active compound on vascular cell adhesion molecule (VCAM) and intercellular adhesion molecule (ICAM) adhesion to melanoma cells. Normal and tumor angiogenesis were evaluated in vivo by chicken embryo chorioallantoic membrane (CAM) assay. The two test triterpenoid acids, UA and OA, exerted differential effects in vitro and in vivo on the SK-MEL-2 melanoma cells. UA exerted a significant and dose-dependent anti-proliferative effect in vitro, compared to OA. The cytotoxic effects in vitro on the melanoma cells were determined by the examining alterations in the cell cycle phases induced by UA that lead to cell arrest in the S phase. Moreover, UA was found to affect SK-MEL-2 melanoma cell invasiveness by limiting the cell adhesion capacity to ICAM molecules, but not influencing their adhesion to VCAM molecules. On the whole, in this study, by assessing the effects of the two triterpenoids in vivo, our results revealed that OA had a greater potential to impair the invasive capacity and tumor angiogenesis compared with UA.</description><subject>Angiogenesis Inhibitors - pharmacology</subject><subject>Animals</subject><subject>anti-angiogenic</subject><subject>anti-invasive</subject><subject>Care and treatment</subject><subject>Cell Adhesion - drug effects</subject><subject>Cell Cycle - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Chick Embryo</subject><subject>Chorioallantoic Membrane - blood supply</subject><subject>Chorioallantoic Membrane - drug effects</subject><subject>Development and progression</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Kinases</subject><subject>Melanoma</subject><subject>Melanoma - blood supply</subject><subject>Melanoma - drug therapy</subject><subject>Melanoma - pathology</subject><subject>Mutation</subject><subject>Neovascularization, Physiologic - drug effects</subject><subject>oleanolic acid</subject><subject>Oleanolic Acid - pharmacology</subject><subject>Skin cancer</subject><subject>Skin Neoplasms - blood supply</subject><subject>Skin Neoplasms - drug therapy</subject><subject>Skin Neoplasms - pathology</subject><subject>Studies</subject><subject>Terpenoids</subject><subject>Triterpenes - pharmacology</subject><subject>Ursolic Acid</subject><issn>1019-6439</issn><issn>1791-2423</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkk1vEzEQhi0EoqVw5IosIcHJwR9rO-ZQqaoCVARxoAdulmN7G0e7dljvRuq_Z9KUqJGQD56PZ16NPYPQW0ZnYm74p7QpM06ZnjVM0WfonGnDCG-4eA42ZYaoRpgz9KrWDaVcSspeojNuqDCNYufo96Jtox8rLi2ehlq65LHLAZcuuvzglYx_fSc_FkvCcR87iPYO-9h19TO-yXiXxqE8lKS9swO7VndfX6MXretqfPN4X6DbL4vb629k-fPrzfXVknjZyJHM_UqEaBQXkXETNFeeGwkpJngwUTApOdPM8wA9Bz5nZhW1k94Y5ShV4gJdHmS306qPwcc8Dq6z2yH1bri3xSV7mslpbe_KzkqlBeUCBN4_CgzlzxTraDdlGjK0bJmZK6WkBvJI3bku2pTbAmK-T9XbK8kVVdpoDtTsPxScEPvkS45tgvhJwYcnBevounENM5jGVHI9BckB9EOpdYjt8YWM2v0eWNgDu98Du98D4N89_ZYj_W_wAHw8AHULs0uh1CMDSkQyQhVhCsbwF_b0ty0</recordid><startdate>20171201</startdate><enddate>20171201</enddate><creator>Caunii, Angela</creator><creator>Oprean, Camelia</creator><creator>Cristea, Mirabela</creator><creator>Ivan, Alexandra</creator><creator>Danciu, Corina</creator><creator>Tatu, Calin</creator><creator>Paunescu, Virgil</creator><creator>Marti, Daniela</creator><creator>Tzanakakis, George</creator><creator>Spandidos, Demetrios A</creator><creator>Tsatsakis, Aristides</creator><creator>Susan, Razvan</creator><creator>Soica, Codruta</creator><creator>Avram, Stefana</creator><creator>Dehelean, Cristina</creator><general>D.A. 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pharmacology</topic><topic>Ursolic Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caunii, Angela</creatorcontrib><creatorcontrib>Oprean, Camelia</creatorcontrib><creatorcontrib>Cristea, Mirabela</creatorcontrib><creatorcontrib>Ivan, Alexandra</creatorcontrib><creatorcontrib>Danciu, Corina</creatorcontrib><creatorcontrib>Tatu, Calin</creatorcontrib><creatorcontrib>Paunescu, Virgil</creatorcontrib><creatorcontrib>Marti, Daniela</creatorcontrib><creatorcontrib>Tzanakakis, George</creatorcontrib><creatorcontrib>Spandidos, Demetrios A</creatorcontrib><creatorcontrib>Tsatsakis, Aristides</creatorcontrib><creatorcontrib>Susan, Razvan</creatorcontrib><creatorcontrib>Soica, Codruta</creatorcontrib><creatorcontrib>Avram, Stefana</creatorcontrib><creatorcontrib>Dehelean, Cristina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caunii, Angela</au><au>Oprean, Camelia</au><au>Cristea, Mirabela</au><au>Ivan, Alexandra</au><au>Danciu, Corina</au><au>Tatu, Calin</au><au>Paunescu, Virgil</au><au>Marti, Daniela</au><au>Tzanakakis, George</au><au>Spandidos, Demetrios A</au><au>Tsatsakis, Aristides</au><au>Susan, Razvan</au><au>Soica, Codruta</au><au>Avram, Stefana</au><au>Dehelean, Cristina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of ursolic and oleanolic on SK-MEL-2 melanoma cells: In vitro and in vivo assays</atitle><jtitle>International journal of oncology</jtitle><addtitle>Int J Oncol</addtitle><date>2017-12-01</date><risdate>2017</risdate><volume>51</volume><issue>6</issue><spage>1651</spage><epage>1660</epage><pages>1651-1660</pages><issn>1019-6439</issn><eissn>1791-2423</eissn><abstract>Among the triterpenoids, oleanolic acid (OA) and its isomer, ursolic acid (UA) are promising therapeutic candidates, with potential benefits in the management of melanoma. In this study, we aimed to examine the in vitro and in vivo anti-invasive and anti-metastatic activity of OA and UA to determine their possible usefulness as chemopreventive or chemotherapeutic agents in melanoma. For the in vitro experiments, the anti-proliferative activity of the triterpenic compounds on SK-MEL-2 melanoma cells was examined. The anti-invasive potential was assessed by testing the effects of the active compound on vascular cell adhesion molecule (VCAM) and intercellular adhesion molecule (ICAM) adhesion to melanoma cells. Normal and tumor angiogenesis were evaluated in vivo by chicken embryo chorioallantoic membrane (CAM) assay. The two test triterpenoid acids, UA and OA, exerted differential effects in vitro and in vivo on the SK-MEL-2 melanoma cells. UA exerted a significant and dose-dependent anti-proliferative effect in vitro, compared to OA. The cytotoxic effects in vitro on the melanoma cells were determined by the examining alterations in the cell cycle phases induced by UA that lead to cell arrest in the S phase. Moreover, UA was found to affect SK-MEL-2 melanoma cell invasiveness by limiting the cell adhesion capacity to ICAM molecules, but not influencing their adhesion to VCAM molecules. On the whole, in this study, by assessing the effects of the two triterpenoids in vivo, our results revealed that OA had a greater potential to impair the invasive capacity and tumor angiogenesis compared with UA.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>29039461</pmid><doi>10.3892/ijo.2017.4160</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of oncology, 2017-12, Vol.51 (6), p.1651-1660 |
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| source | Spandidos Publications Journals; MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Angiogenesis Inhibitors - pharmacology Animals anti-angiogenic anti-invasive Care and treatment Cell Adhesion - drug effects Cell Cycle - drug effects Cell Line, Tumor Cell Proliferation - drug effects Chick Embryo Chorioallantoic Membrane - blood supply Chorioallantoic Membrane - drug effects Development and progression Health aspects Humans Kinases Melanoma Melanoma - blood supply Melanoma - drug therapy Melanoma - pathology Mutation Neovascularization, Physiologic - drug effects oleanolic acid Oleanolic Acid - pharmacology Skin cancer Skin Neoplasms - blood supply Skin Neoplasms - drug therapy Skin Neoplasms - pathology Studies Terpenoids Triterpenes - pharmacology Ursolic Acid |
| title | Effects of ursolic and oleanolic on SK-MEL-2 melanoma cells: In vitro and in vivo assays |
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