TALK-1 channels control β cell endoplasmic reticulum Ca2+ homeostasis

TALKing about K+, Ca2+, and ER stressInsulin secretion is triggered upon depolarization of β cells, which activates voltage-gated Ca2+ channels in the plasma membrane. Ca2+ that enters the β cells is taken up by the endoplasmic reticulum (ER) and released near Ca2+-activated K+ channels in the plasm...

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Veröffentlicht in:	Science signaling 2017-09, Vol.10 (497)
Hauptverfasser:	Vierra, Nicholas C, Dadi, Prasanna K, Milian, Sarah C, Dickerson, Matthew T, Jordan, Kelli L, Gilon, Patrick, Jacobson, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium (reticular) Calcium channels Calcium channels (voltage-gated) Calcium homeostasis Calcium ions Channels Depolarization Diabetes Diabetes mellitus Diet Endoplasmic reticulum Fluctuations Flux Handling High fat diet Homeostasis Insulin Insulin secretion Islets of Langerhans Leak channels Mice mRNA Pancreas Pathogenesis Potassium Potassium channels (calcium-gated) Potassium currents Regulators Rodents Secretion Stress Stresses Therapeutic applications
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