T cells upon activation promote endothelin 1 production in monocytes via IFN-γ and TNF-α

Endothelin 1 (ET-1), mainly produced from vascular endothelial cells, induces vasoconstriction in physiological conditions. The endothelin receptor antagonist is among the most effective agents for pulmonary hypertension. However, little is known about the production source of ET-1 in inflammation a...

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Veröffentlicht in:	Scientific reports 2017-11, Vol.7 (1), p.14500-8, Article 14500
Hauptverfasser:	Shinagawa, Shoshi, Okazaki, Takahiro, Ikeda, Mari, Yudoh, Kazuo, Kisanuki, Yaz Y., Yanagisawa, Masashi, Kawahata, Kimito, Ozaki, Shoichi
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/21 13/51 14/34 14/5 631/1647/2230/1467 631/250/2152/1566/1618 Adaptive Immunity Animals Antigens Bone Marrow Cells - immunology CD3 antigen CD3 Complex - metabolism Cell activation Cell culture Cells, Cultured Endothelial cells Endothelin 1 Endothelin-1 - genetics Endothelin-1 - metabolism Humanities and Social Sciences Humans Hypertension Interferon Interferon-gamma - antagonists & inhibitors Interferon-gamma - metabolism Lymphocytes Lymphocytes T Mice Mice, Transgenic Monocytes Monocytes - cytology Monocytes - immunology multidisciplinary Rodents Science Science (multidisciplinary) Spleen Spleen - cytology Spleen - immunology Stem cell transplantation Stem cells T-Lymphocytes - cytology T-Lymphocytes - immunology Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α Vasoconstriction γ-Interferon
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