Effects of prostaglandin lipid mediators on agonist-induced lung endothelial permeability and inflammation

Prostaglandins (PG), the products of cyclooxygenase-mediated conversion of arachidonic acid, become upregulated in many situations including allergic response, inflammation, and injury, and exhibit a variety of biological activities. Previous studies described barrier-enhancing and anti-inflammatory...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2017-10, Vol.313 (4), p.L710-L721
Hauptverfasser:	Ke, Yunbo, Oskolkova, Olga V, Sarich, Nicolene, Tian, Yufeng, Sitikov, Albert, Tulapurkar, Mohan E, Son, Sophia, Birukova, Anna A, Birukov, Konstantin G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion tests Animals Arachidonic acid Attenuation Bacteria Biological effects Cell Membrane Permeability - drug effects Contractility Cytokines Effects Endothelial cells Endothelium Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Hemostatics - adverse effects Humans Hypersensitivity In vivo methods and tests Inflammation Inflammation - chemically induced Inflammation - drug therapy Inflammation - pathology Inflammatory response Injury analysis Intercellular adhesion molecule 1 Intercellular Adhesion Molecule-1 - metabolism Interleukin 6 Interleukin-6 - metabolism Lipids Lipopolysaccharides Lipopolysaccharides - adverse effects Lung Injury - chemically induced Lung Injury - drug therapy Lung Injury - pathology Lungs Membrane permeability Mice Permeability Prostacyclin Prostaglandin E2 Prostaglandin endoperoxide synthase Prostaglandins Prostaglandins - pharmacology Thrombin Thrombin - adverse effects
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