EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork-Associated DNA Damage Repair

EGFR signaling has been implicated in hypoxia-associated resistance to radiation or chemotherapy. Non-small cell lung carcinomas (NSCLC) with activating L858R or ΔE746-E750 EGFR mutations exhibit elevated EGFR activity and downstream signaling. Here, relative to wild-type (WT) EGFR, mutant (MT) EGFR...

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Veröffentlicht in:	Molecular cancer research 2017-11, Vol.15 (11), p.1503-1516
Hauptverfasser:	Saki, Mohammad, Makino, Haruhiko, Javvadi, Prashanthi, Tomimatsu, Nozomi, Ding, Liang-Hao, Clark, Jennifer E, Gavin, Elaine, Takeda, Kenichi, Andrews, Joel, Saha, Debabrata, Story, Michael D, Burma, Sandeep, Nirodi, Chaitanya S
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Acid Anhydride Hydrolases Cancer Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Cell cycle Cell Hypoxia Cell Line, Tumor Cell Survival - drug effects Cell Survival - radiation effects Cetuximab - pharmacology Chemotherapy Deoxyribonucleic acid DNA DNA - metabolism DNA biosynthesis DNA Damage DNA Repair DNA Repair Enzymes - genetics DNA Replication DNA-Binding Proteins - genetics Epidermal growth factor receptors Epithelial cells ErbB Receptors - genetics Gene expression Homologous recombination Homology Humans Hypoxia Lesions Lethality Lung carcinoma Lung Neoplasms - drug therapy Lung Neoplasms - genetics Monoclonal antibodies Mutation Non-small cell lung carcinoma Nuclei Poly(ADP-ribose) polymerase Protein A Radiation Radiation damage Radiation tolerance Radiation Tolerance - drug effects Radiation-Sensitizing Agents - pharmacology Radiosensitivity Repair Replication Replication forks Replication protein A Signaling Small cell lung carcinoma Targeted cancer therapy Tumor cells
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