Nuclear Envelope Rupture Is Enhanced by Loss of p53 or Rb

The mammalian nuclear envelope (NE) forms a stable physical barrier between the nucleus and the cytoplasm, normally breaking down only during mitosis. However, spontaneous transient NE rupture in interphase can occur when NE integrity is compromised, such as when the nucleus experiences mechanical s...

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Veröffentlicht in:	Molecular cancer research 2017-11, Vol.15 (11), p.1579-1586
Hauptverfasser:	Yang, Zhe, Maciejowski, John, de Lange, Titia
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cancer Cell Line Cell Movement Chromatin CRISPR CRISPR-Cas Systems Cytoplasm Epithelial Cells - cytology Filaments Gene Editing Gene expression Gene Knockdown Techniques Genetic modification Genomes Humans Integrity Lamins Mitosis Neoplasms - genetics Nuclear Envelope - physiology Nuclease Nuclei p53 Protein Proteins Retinoblastoma Binding Proteins - genetics Rupture Rupturing Stress, Mechanical Suppressors Tumor cell lines Tumor suppression Tumor Suppressor Protein p53 - genetics Ubiquitin-Protein Ligases - genetics
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