SGK1/Nedd4–2 signaling pathway regulates the activity of human organic anion transporters 3

Human organic anion transporter 3 (hOAT3) is localized at the basolateral membrane of renal proximal tubule cells and facilitates the renal secretion of numerous clinical drugs, including anti‐HIV therapeutics, anti‐tumor drugs, antibiotics, antihypertension drugs and anti‐inflammatories. The presen...

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Veröffentlicht in:	Biopharmaceutics & drug disposition 2017-11, Vol.38 (8), p.449-457
Hauptverfasser:	Wang, Haoxun, You, Guofeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics Benzoates - pharmacology Biotinylation Bridged Bicyclo Compounds, Heterocyclic - pharmacology Chlorocebus aethiops COS Cells drug transporter Estrone - analogs & derivatives Estrone - metabolism Glucocorticoids Humans Immediate-Early Proteins - antagonists & inhibitors Immediate-Early Proteins - genetics Immediate-Early Proteins - metabolism Kidneys Kinases Nedd4 Ubiquitin Protein Ligases - genetics Nedd4 Ubiquitin Protein Ligases - metabolism organic anion transporter Organic Anion Transporters, Sodium-Independent - genetics Organic Anion Transporters, Sodium-Independent - metabolism Overexpression Protein Kinase Inhibitors - pharmacology Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism regulation Secretion serum and glucocorticoid‐inducible kinase Signal Transduction Ubiquitin ubiquitin ligase Ubiquitin-protein ligase Ubiquitination
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