Targeting RNA-Polymerase I in Both Chemosensitive and Chemoresistant Populations in Epithelial Ovarian Cancer

A hallmark of neoplasia is increased ribosome biogenesis, and targeting this process with RNA polymerase I (Pol I) inhibitors has shown some efficacy. We examined the contribution and potential targeting of ribosomal machinery in chemotherapy-resistant and -sensitive models of ovarian cancer. Pol I...

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Veröffentlicht in:	Clinical cancer research 2017-11, Vol.23 (21), p.6529-6540
Hauptverfasser:	Cornelison, Robert, Dobbin, Zachary C, Katre, Ashwini A, Jeong, Dae Hoon, Zhang, Yinfeng, Chen, Dongquan, Petrova, Yuliya, Llaneza, Danielle C, Steg, Adam D, Parsons, Laura, Schneider, David A, Landen, Charles N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Benzothiazoles - administration & dosage Benzothiazoles - adverse effects Biotechnology Cancer Carcinoma, Ovarian Epithelial Cell culture Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Chemotherapy Deoxyribonucleic acid DNA DNA damage DNA-directed RNA polymerase Dormancy Drug Resistance, Neoplasm - genetics Experimental design Female Gene Expression Regulation, Neoplastic - drug effects Humans Mice Naphthyridines - administration & dosage Naphthyridines - adverse effects Neoplasms, Glandular and Epithelial - drug therapy Neoplasms, Glandular and Epithelial - genetics Neoplasms, Glandular and Epithelial - pathology Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Populations Ribonucleic acid RNA RNA polymerase RNA Polymerase I - antagonists & inhibitors RNA Polymerase I - genetics rRNA Signal Transduction - drug effects Tumor cell lines Tumors Viability Xenograft Model Antitumor Assays Xenografts
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