Cancer cell dormancy: mechanisms and implications of cancer recurrence and metastasis
More recently, disease metastasis and relapse in many cancer patients several years (even some decades) after surgical remission are regarded as tumor dormancy. However, the knowledge of this phenomenon is cripplingly limited. Substantial quantities of reviews have summarized three main potential mo...
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| Veröffentlicht in: | OncoTargets and therapy 2017-01, Vol.10, p.5219-5228 |
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| creator | Gao, Xiao-Lei Zhang, Mei Tang, Ya-Ling Liang, Xin-Hua |
| description | More recently, disease metastasis and relapse in many cancer patients several years (even some decades) after surgical remission are regarded as tumor dormancy. However, the knowledge of this phenomenon is cripplingly limited. Substantial quantities of reviews have summarized three main potential models that can be put forth to explain such process, including angiogenic dormancy, immunologic dormancy, and cellular dormancy. In this review, newly uncovered mechanisms governing cancer cell dormancy are discussed, with an emphasis on the cross talk between dormant cancer cells and their microenvironments. In addition, potential mechanisms of reactivation of these dormant cells in certain anatomic sites including lymph nodes and bone marrow are discussed. Molecular mechanism of cellular dormancy in head and neck cancer is also involved. |
| doi_str_mv | 10.2147/OTT.S140854 |
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However, the knowledge of this phenomenon is cripplingly limited. Substantial quantities of reviews have summarized three main potential models that can be put forth to explain such process, including angiogenic dormancy, immunologic dormancy, and cellular dormancy. In this review, newly uncovered mechanisms governing cancer cell dormancy are discussed, with an emphasis on the cross talk between dormant cancer cells and their microenvironments. In addition, potential mechanisms of reactivation of these dormant cells in certain anatomic sites including lymph nodes and bone marrow are discussed. Molecular mechanism of cellular dormancy in head and neck cancer is also involved.</description><identifier>ISSN: 1178-6930</identifier><identifier>EISSN: 1178-6930</identifier><identifier>DOI: 10.2147/OTT.S140854</identifier><identifier>PMID: 29138574</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>Analysis ; Angiogenesis ; Bone cancer ; Bone marrow ; Breast cancer ; Cancer metastasis ; Cancer therapies ; Care and treatment ; Cell division ; Chemotherapy ; Development and progression ; Disease ; Dormancy ; Genetic aspects ; Genotype & phenotype ; Head & neck cancer ; Health aspects ; Hypoxia ; Lymph nodes ; Lymphatic system ; Metastases ; Metastasis ; Microenvironments ; Molecular modelling ; Phosphatase ; Prognosis ; Recurrence (Disease) ; Remission ; Review ; Stem cells</subject><ispartof>OncoTargets and therapy, 2017-01, Vol.10, p.5219-5228</ispartof><rights>COPYRIGHT 2017 Dove Medical Press Limited</rights><rights>2017. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Gao et al. This work is published and licensed by Dove Medical Press Limited 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c573t-2b0de3ea5c979a44b46c639f82e6b255ab0a6b9357193c7c3bfa79f4beb7410e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667781/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667781/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,3849,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29138574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Xiao-Lei</creatorcontrib><creatorcontrib>Zhang, Mei</creatorcontrib><creatorcontrib>Tang, Ya-Ling</creatorcontrib><creatorcontrib>Liang, Xin-Hua</creatorcontrib><title>Cancer cell dormancy: mechanisms and implications of cancer recurrence and metastasis</title><title>OncoTargets and therapy</title><addtitle>Onco Targets Ther</addtitle><description>More recently, disease metastasis and relapse in many cancer patients several years (even some decades) after surgical remission are regarded as tumor dormancy. 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| subjects | Analysis Angiogenesis Bone cancer Bone marrow Breast cancer Cancer metastasis Cancer therapies Care and treatment Cell division Chemotherapy Development and progression Disease Dormancy Genetic aspects Genotype & phenotype Head & neck cancer Health aspects Hypoxia Lymph nodes Lymphatic system Metastases Metastasis Microenvironments Molecular modelling Phosphatase Prognosis Recurrence (Disease) Remission Review Stem cells |
| title | Cancer cell dormancy: mechanisms and implications of cancer recurrence and metastasis |
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