Hypoxia and Bone Metastatic Disease
Purpose of Review This review highlights our current knowledge of oxygen tensions in the bone marrow, and how low oxygen tensions (hypoxia) regulate tumor metastasis to and colonization of the bone marrow. Recent Findings The bone marrow is a relatively hypoxic microenvironment, but oxygen tensions...
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| Veröffentlicht in: | Current osteoporosis reports 2017-08, Vol.15 (4), p.231-238 |
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| creator | Johnson, Rachelle W. Sowder, Miranda E. Giaccia, Amato J. |
| description | Purpose of Review
This review highlights our current knowledge of oxygen tensions in the bone marrow, and how low oxygen tensions (hypoxia) regulate tumor metastasis to and colonization of the bone marrow.
Recent Findings
The bone marrow is a relatively hypoxic microenvironment, but oxygen tensions fluctuate throughout the marrow cavity and across the endosteal and periosteal surfaces. Recent advances in imaging have made it possible to better characterize these fluctuations in bone oxygenation, but technical challenges remain. We have compiled evidence from multiple groups that suggests that hypoxia or hypoxia inducible factor (HIF) signaling may induce spontaneous metastasis to the bone and promote tumor colonization of bone, particularly in the case of breast cancer dissemination to the bone marrow.
Summary
We are beginning to understand oxygenation patterns within the bone compartment and the role for hypoxia and HIF signaling in tumor cell dissemination to the bone marrow, but further studies are warranted. |
| doi_str_mv | 10.1007/s11914-017-0378-8 |
| format | Article |
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This review highlights our current knowledge of oxygen tensions in the bone marrow, and how low oxygen tensions (hypoxia) regulate tumor metastasis to and colonization of the bone marrow.
Recent Findings
The bone marrow is a relatively hypoxic microenvironment, but oxygen tensions fluctuate throughout the marrow cavity and across the endosteal and periosteal surfaces. Recent advances in imaging have made it possible to better characterize these fluctuations in bone oxygenation, but technical challenges remain. We have compiled evidence from multiple groups that suggests that hypoxia or hypoxia inducible factor (HIF) signaling may induce spontaneous metastasis to the bone and promote tumor colonization of bone, particularly in the case of breast cancer dissemination to the bone marrow.
Summary
We are beginning to understand oxygenation patterns within the bone compartment and the role for hypoxia and HIF signaling in tumor cell dissemination to the bone marrow, but further studies are warranted.</description><identifier>ISSN: 1544-1873</identifier><identifier>EISSN: 1544-2241</identifier><identifier>DOI: 10.1007/s11914-017-0378-8</identifier><identifier>PMID: 28597139</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Bone and Bones - metabolism ; Bone Marrow - metabolism ; Bone Neoplasms - metabolism ; Bone Neoplasms - secondary ; Breast Neoplasms - pathology ; Cancer-induced Musculoskeletal Diseases (M Reagan and E Keller ; Epidemiology ; Female ; Humans ; Hypoxia - metabolism ; Hypoxia-Inducible Factor 1 - metabolism ; Medicine ; Medicine & Public Health ; Neoplasm Metastasis ; Orthopedics ; Section Editors ; Signal Transduction ; Topical Collection on Cancer-induced Musculoskeletal Diseases</subject><ispartof>Current osteoporosis reports, 2017-08, Vol.15 (4), p.231-238</ispartof><rights>Springer Science+Business Media New York 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-af5da4a5332d78ce95788dc2cb6c18eebf22fa46c03dbb24fe6a22a6c5d3ed8a3</citedby><cites>FETCH-LOGICAL-c442t-af5da4a5332d78ce95788dc2cb6c18eebf22fa46c03dbb24fe6a22a6c5d3ed8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11914-017-0378-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11914-017-0378-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28597139$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnson, Rachelle W.</creatorcontrib><creatorcontrib>Sowder, Miranda E.</creatorcontrib><creatorcontrib>Giaccia, Amato J.</creatorcontrib><title>Hypoxia and Bone Metastatic Disease</title><title>Current osteoporosis reports</title><addtitle>Curr Osteoporos Rep</addtitle><addtitle>Curr Osteoporos Rep</addtitle><description>Purpose of Review
This review highlights our current knowledge of oxygen tensions in the bone marrow, and how low oxygen tensions (hypoxia) regulate tumor metastasis to and colonization of the bone marrow.
Recent Findings
The bone marrow is a relatively hypoxic microenvironment, but oxygen tensions fluctuate throughout the marrow cavity and across the endosteal and periosteal surfaces. Recent advances in imaging have made it possible to better characterize these fluctuations in bone oxygenation, but technical challenges remain. We have compiled evidence from multiple groups that suggests that hypoxia or hypoxia inducible factor (HIF) signaling may induce spontaneous metastasis to the bone and promote tumor colonization of bone, particularly in the case of breast cancer dissemination to the bone marrow.
Summary
We are beginning to understand oxygenation patterns within the bone compartment and the role for hypoxia and HIF signaling in tumor cell dissemination to the bone marrow, but further studies are warranted.</description><subject>Bone and Bones - metabolism</subject><subject>Bone Marrow - metabolism</subject><subject>Bone Neoplasms - metabolism</subject><subject>Bone Neoplasms - secondary</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer-induced Musculoskeletal Diseases (M Reagan and E Keller</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypoxia - metabolism</subject><subject>Hypoxia-Inducible Factor 1 - metabolism</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neoplasm Metastasis</subject><subject>Orthopedics</subject><subject>Section Editors</subject><subject>Signal Transduction</subject><subject>Topical Collection on Cancer-induced Musculoskeletal Diseases</subject><issn>1544-1873</issn><issn>1544-2241</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EoqXwA1hQJRaWgM92bGdBgvJRpCIWmK2Lcymp2qTECaL_nlQtFSxMd9L7caeHsVPgl8C5uQoACaiIg4m4NDaye6wPsVKREAr2tztYI3vsKIQZ50KAkoesJ2ycGJBJn52PV8vqq8Ahltnwtipp-EwNhgabwg_vikAY6Jgd5DgPdLKdA_b2cP86GkeTl8en0c0k8kqJJsI8zlBhLKXIjPWUxMbazAufag-WKM2FyFFpz2WWpkLlpFEI1D7OJGUW5YBdb3qXbbqgzFPZ1Dh3y7pYYL1yFRbur1IW725afbpYa6N13BVcbAvq6qOl0LhFETzN51hS1QYHCU_AQCJ1Z4WN1ddVCDXluzPA3Rqu28B1HVy3hutslzn7_d8u8UOzM4iNIXRSOaXazaq2Ljtm_7R-Ax3YhYw</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Johnson, Rachelle W.</creator><creator>Sowder, Miranda E.</creator><creator>Giaccia, Amato J.</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170801</creationdate><title>Hypoxia and Bone Metastatic Disease</title><author>Johnson, Rachelle W. ; Sowder, Miranda E. ; Giaccia, Amato J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-af5da4a5332d78ce95788dc2cb6c18eebf22fa46c03dbb24fe6a22a6c5d3ed8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Bone and Bones - metabolism</topic><topic>Bone Marrow - metabolism</topic><topic>Bone Neoplasms - metabolism</topic><topic>Bone Neoplasms - secondary</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer-induced Musculoskeletal Diseases (M Reagan and E Keller</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypoxia - metabolism</topic><topic>Hypoxia-Inducible Factor 1 - metabolism</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neoplasm Metastasis</topic><topic>Orthopedics</topic><topic>Section Editors</topic><topic>Signal Transduction</topic><topic>Topical Collection on Cancer-induced Musculoskeletal Diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johnson, Rachelle W.</creatorcontrib><creatorcontrib>Sowder, Miranda E.</creatorcontrib><creatorcontrib>Giaccia, Amato J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current osteoporosis reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johnson, Rachelle W.</au><au>Sowder, Miranda E.</au><au>Giaccia, Amato J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypoxia and Bone Metastatic Disease</atitle><jtitle>Current osteoporosis reports</jtitle><stitle>Curr Osteoporos Rep</stitle><addtitle>Curr Osteoporos Rep</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>15</volume><issue>4</issue><spage>231</spage><epage>238</epage><pages>231-238</pages><issn>1544-1873</issn><eissn>1544-2241</eissn><abstract>Purpose of Review
This review highlights our current knowledge of oxygen tensions in the bone marrow, and how low oxygen tensions (hypoxia) regulate tumor metastasis to and colonization of the bone marrow.
Recent Findings
The bone marrow is a relatively hypoxic microenvironment, but oxygen tensions fluctuate throughout the marrow cavity and across the endosteal and periosteal surfaces. Recent advances in imaging have made it possible to better characterize these fluctuations in bone oxygenation, but technical challenges remain. We have compiled evidence from multiple groups that suggests that hypoxia or hypoxia inducible factor (HIF) signaling may induce spontaneous metastasis to the bone and promote tumor colonization of bone, particularly in the case of breast cancer dissemination to the bone marrow.
Summary
We are beginning to understand oxygenation patterns within the bone compartment and the role for hypoxia and HIF signaling in tumor cell dissemination to the bone marrow, but further studies are warranted.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28597139</pmid><doi>10.1007/s11914-017-0378-8</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Current osteoporosis reports, 2017-08, Vol.15 (4), p.231-238 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Bone and Bones - metabolism Bone Marrow - metabolism Bone Neoplasms - metabolism Bone Neoplasms - secondary Breast Neoplasms - pathology Cancer-induced Musculoskeletal Diseases (M Reagan and E Keller Epidemiology Female Humans Hypoxia - metabolism Hypoxia-Inducible Factor 1 - metabolism Medicine Medicine & Public Health Neoplasm Metastasis Orthopedics Section Editors Signal Transduction Topical Collection on Cancer-induced Musculoskeletal Diseases |
| title | Hypoxia and Bone Metastatic Disease |
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